Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EMD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Gene profile: EMD (Emerin), a nuclear envelope protein involved in Emery-Dreifuss muscular dystrophy and X-linked dilated cardiomyopathy
| Gene Symbol | EMD |
| Full Name | Emerin |
| Chromosome | Xq28 |
| Function | The EMD gene encodes emerin, a 34-kDa integral membrane protein of the inner nuclear envelope. |
| Primary Expression | Skeletal Muscle, Cardiac Muscle, Nuclear Envelope |
| Pathways | MAPK signaling, apoptosis pathway, autophagy pathway, necroptosis, oxidative stress response |
| UniProt ID | P50402 |
| NCBI Gene ID | 2010 |
| Ensembl ID | ENSG00000102119 |
| OMIM | 300384 |
| GeneCards | EMD |
| Human Protein Atlas | EMD |
| Associated Diseases | AD, ALI, ALS, Alzheimer, Autoimmune |
| Interactions | MAPK8, RHOT1, BNIP3L, NDP52, HIF1A, MAP1LC3B |
| KG Connections | 425 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
EMD["EMD"] -->|"Interacts With"| Dementia["Dementia"]
EMD["EMD"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
EMD["EMD"] -->|"Interacts With"| Als["Als"]
EMD["EMD"] -->|"Interacts With"| Alzheimer["Alzheimer"]
EMD["EMD"] -->|"Interacts With"| Parkinson["Parkinson"]
EMD["EMD"] -->|"Interacts With"| Ms["Ms"]
EMD["EMD"] -->|"Activates"| Cancer["Cancer"]
EMD["EMD"] -->|"Activates"| Multiple_Sclerosis["Multiple Sclerosis"]
CAT["CAT"] -->|"Interacts With"| EMD["EMD"]
OPTN["OPTN"] -->|"Interacts With"| EMD["EMD"]
DNM1L["DNM1L"] -->|"Interacts With"| EMD["EMD"]
CANX["CANX"] -->|"Interacts With"| EMD["EMD"]
LGALS3["LGALS3"] -->|"Interacts With"| EMD["EMD"]
style EMD fill:#8d4900,color:#e0e0e0
style Dementia fill:#b71c1c,color:#e0e0e0
style Cardiovascular fill:#b71c1c,color:#e0e0e0
style Als fill:#b71c1c,color:#e0e0e0
style Alzheimer fill:#b71c1c,color:#e0e0e0
style Parkinson fill:#b71c1c,color:#e0e0e0
style Ms fill:#b71c1c,color:#e0e0e0
style Cancer fill:#b71c1c,color:#e0e0e0
style Multiple_Sclerosis fill:#b71c1c,color:#e0e0e0
style CAT fill:#8d4900,color:#e0e0e0
style OPTN fill:#8d4900,color:#e0e0e0
style DNM1L fill:#8d4900,color:#e0e0e0
style CANX fill:#8d4900,color:#e0e0e0
style LGALS3 fill:#8d4900,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Encephalitis | activates | disease | 0.65 |
| Dementia | interacts_with | disease | 0.65 |
| Cardiovascular | interacts_with | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Alzheimer | interacts_with | disease | 0.65 |
| Parkinson | interacts_with | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Multiple Sclerosis | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Autoimmune | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | interacts_with | disease | 0.65 |
| Cardiovascular | therapeutic_target | disease | 0.65 |
| Frontotemporal Dementia | interacts_with | disease | 0.65 |
| Ftd | interacts_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Autoimmune | associated_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Multiple Sclerosis | associated_with | disease | 0.65 |
| ALS | interacts_with | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| MAPK8 | interacts_with | gene | 0.60 |
| RHOT1 | interacts_with | gene | 0.60 |
| BNIP3L | interacts_with | gene | 0.60 |
| NDP52 | interacts_with | gene | 0.60 |
| HIF1A | interacts_with | gene | 0.60 |
| MAP1LC3B | interacts_with | gene | 0.60 |
| GBA | interacts_with | gene | 0.60 |
| FUNDC1 | interacts_with | gene | 0.60 |
| AMBRA1 | interacts_with | gene | 0.60 |
| PINK1 | interacts_with | gene | 0.60 |
| BCL2L13 | interacts_with | gene | 0.60 |
| NLRP3 | interacts_with | gene | 0.60 |
| ABCD3 | interacts_with | gene | 0.60 |
| FIP200 | interacts_with | gene | 0.60 |
| RTN3 | interacts_with | gene | 0.60 |
| SESN2 | interacts_with | gene | 0.60 |
| SNCA | interacts_with | gene | 0.60 |
| TAX1BP1 | interacts_with | gene | 0.60 |
| FAM134B | interacts_with | gene | 0.60 |
| CHOP | interacts_with | gene | 0.60 |
| STING1 | interacts_with | gene | 0.60 |
| DISC1 | interacts_with | gene | 0.60 |
| FMR1 | interacts_with | gene | 0.60 |
| CANX | interacts_with | gene | 0.60 |
| MIRO1 | interacts_with | gene | 0.60 |
| EIF2S1 | interacts_with | gene | 0.60 |
| CAT | interacts_with | gene | 0.60 |
| LC3 | interacts_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CAT | interacts_with | gene | 0.60 |
| OPTN | interacts_with | gene | 0.60 |
| DNM1L | interacts_with | gene | 0.60 |
| CANX | interacts_with | gene | 0.60 |
| LGALS3 | interacts_with | gene | 0.60 |
| CALCOCO2 | interacts_with | gene | 0.60 |
| G3BP1 | interacts_with | gene | 0.60 |
| PEX3 | interacts_with | gene | 0.60 |
| SQSTM1 | interacts_with | gene | 0.60 |
| BCL2 | interacts_with | gene | 0.60 |
| LMNA | interacts_with | gene | 0.60 |
| STING1 | interacts_with | gene | 0.60 |
| TAX1BP1 | interacts_with | gene | 0.60 |
| ATM | interacts_with | gene | 0.60 |
| SNCAIP | interacts_with | gene | 0.60 |
| RB1CC1 | interacts_with | gene | 0.60 |
| MFN1 | interacts_with | gene | 0.60 |
| ERN1 | interacts_with | gene | 0.60 |
| PARKIN | interacts_with | gene | 0.60 |
| FMR1 | interacts_with | gene | 0.60 |
| SNCA | interacts_with | gene | 0.60 |
| FAM134B | interacts_with | gene | 0.60 |
| LC3 | interacts_with | gene | 0.60 |
| EPAS1 | interacts_with | gene | 0.60 |
| MIRO1 | interacts_with | gene | 0.60 |
| CTSD | interacts_with | gene | 0.60 |
| RB1 | interacts_with | gene | 0.60 |
| EIF2AK3 | interacts_with | gene | 0.60 |
| PRKN | interacts_with | gene | 0.60 |
| BCL2L11 | interacts_with | gene | 0.60 |
| MUL1 | interacts_with | gene | 0.60 |
| BNIP3 | interacts_with | gene | 0.60 |
| DISC1 | interacts_with | gene | 0.60 |
| EIF2S1 | interacts_with | gene | 0.60 |
| RIPK3 | interacts_with | gene | 0.60 |
| DRP1 | interacts_with | gene | 0.60 |
| CHOP | interacts_with | gene | 0.60 |
| BECN1 | interacts_with | gene | 0.60 |
| PTEN | interacts_with | gene | 0.60 |
| DDIT3 | interacts_with | gene | 0.60 |
| NBR1 | interacts_with | gene | 0.60 |
| AQP4 | activates | gene | 0.60 |
| MAX | activates | gene | 0.60 |
| ABCD3 | interacts_with | gene | 0.60 |
| MAP1LC3B | interacts_with | gene | 0.60 |
| AMBRA1 | interacts_with | gene | 0.60 |
| BNIP3L | interacts_with | gene | 0.60 |
| HIF1A | interacts_with | gene | 0.60 |
| GBA | interacts_with | gene | 0.60 |
| NDP52 | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||