gene

EMD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EMD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

425Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

Gene profile: EMD (Emerin), a nuclear envelope protein involved in Emery-Dreifuss muscular dystrophy and X-linked dilated cardiomyopathy

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🧬 Gene Info
Gene SymbolEMD
Full NameEmerin
ChromosomeXq28
FunctionThe EMD gene encodes emerin, a 34-kDa integral membrane protein of the inner nuclear envelope.
Primary ExpressionSkeletal Muscle, Cardiac Muscle, Nuclear Envelope
PathwaysMAPK signaling, apoptosis pathway, autophagy pathway, necroptosis, oxidative stress response
UniProt IDP50402
NCBI Gene ID2010
Ensembl IDENSG00000102119
OMIM300384
GeneCardsEMD
Human Protein AtlasEMD
Associated DiseasesAD, ALI, ALS, Alzheimer, Autoimmune
InteractionsMAPK8, RHOT1, BNIP3L, NDP52, HIF1A, MAP1LC3B
KG Connections425 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: EMD — AlphaFold P50402 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

EMD — Emerin

gene · 1032 words

Retromer Dysfunction in Corticobasal Syndrome

mechanism · 3576 words

TOR1A Gene

gene · 3432 words

SYNE2 Gene

gene · 1999 words

LMNA Protein

protein · 1305 words

CHOP Protein

protein · 1013 words

Pathway Diagram

graph TD
    EMD["EMD"] -->|"Interacts With"| Dementia["Dementia"]
    EMD["EMD"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    EMD["EMD"] -->|"Interacts With"| Als["Als"]
    EMD["EMD"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    EMD["EMD"] -->|"Interacts With"| Parkinson["Parkinson"]
    EMD["EMD"] -->|"Interacts With"| Ms["Ms"]
    EMD["EMD"] -->|"Activates"| Cancer["Cancer"]
    EMD["EMD"] -->|"Activates"| Multiple_Sclerosis["Multiple Sclerosis"]
    CAT["CAT"] -->|"Interacts With"| EMD["EMD"]
    OPTN["OPTN"] -->|"Interacts With"| EMD["EMD"]
    DNM1L["DNM1L"] -->|"Interacts With"| EMD["EMD"]
    CANX["CANX"] -->|"Interacts With"| EMD["EMD"]
    LGALS3["LGALS3"] -->|"Interacts With"| EMD["EMD"]
    style EMD fill:#8d4900,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Multiple_Sclerosis fill:#b71c1c,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style DNM1L fill:#8d4900,color:#e0e0e0
    style CANX fill:#8d4900,color:#e0e0e0
    style LGALS3 fill:#8d4900,color:#e0e0e0

Outgoing (263)

TargetRelationTypeStr
Encephalitisactivatesdisease0.65
Dementiainteracts_withdisease0.65
Cardiovascularinteracts_withdisease0.65
Alsinteracts_withdisease0.65
Alzheimerinteracts_withdisease0.65

Incoming (162)

SourceRelationTypeStr
CATinteracts_withgene0.60
OPTNinteracts_withgene0.60
DNM1Linteracts_withgene0.60
CANXinteracts_withgene0.60
LGALS3interacts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found