BCL2L11

Understanding Entity Pages

This page aggregates everything SciDEX knows about BCL2L11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

BCL2L11 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, implicated in, therapeutic target. Associated with AD, ALI, Als. Connected to 190 entities in the SciDEX knowledge graph.

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flowchart TD
    FOXO["FOXO<br/>Transcription Factor"] --|"activates"|--> BCL2L11["BCL2L11 (BIM)<br/>Pro-apoptotic Protein"]
    
    BCL2L11 --> Apoptosis["Neuronal Apoptosis<br/>Cell Death"]
    
    PTEN["PTEN<br/>Tumor Suppressor"] --|"interacts_with"|--> BCL2L11
    MAPK8["MAPK8 (JNK)<br/>Stress Kinase"] --|"activates"|--> BCL2L11
    
    BCL2L11 --|"interacts_with"|--> BNIP3["BNIP3<br/>Mitochondrial Death Protein"]
    BCL2L11 --|"interacts_with"|--> CHOP["CHOP/DDIT3<br/>ER Stress Response"]
    
    ER_Stress["ER Stress<br/>Protein Misfolding"] --> CHOP
    Oxidative_Stress["Oxidative Stress<br/>ROS Production"] --> MAPK8
    
    BCL2L11 --|"interacts_with"|--> DRP1["DRP1<br/>Mitochondrial Fission"]
    DRP1 --> Mito_Dysfunction["Mitochondrial<br/>Dysfunction"]
    
    BCL2L11 --|"interacts_with"|--> BECN1["BECN1<br/>Autophagy Regulator"]
    BECN1 --> Autophagy["Impaired Autophagy<br/>Protein Clearance"]
    
    Apoptosis --> Alzheimer["Alzheimer's<br/>Disease"]
    Apoptosis --> Parkinson["Parkinson's<br/>Disease"]
    Apoptosis --> ALS["Amyotrophic Lateral<br/>Sclerosis"]
    Apoptosis --> FTD["Frontotemporal<br/>Dementia"]
    
    Mito_Dysfunction --> Neurodegeneration["Neurodegeneration<br/>Process"]
    Autophagy --> Neurodegeneration
    
    style BCL2L11 fill:#006494
    style FOXO fill:#4a1a6b
    style PTEN fill:#4a1a6b
    style MAPK8 fill:#4a1a6b
    style BECN1 fill:#1b5e20
    style Apoptosis fill:#ef5350
    style ER_Stress fill:#ef5350
    style Oxidative_Stress fill:#ef5350
    style Mito_Dysfunction fill:#ef5350
    style Autophagy fill:#ef5350
    style Neurodegeneration fill:#ef5350
    style Alzheimer fill:#5d4400
    style Parkinson fill:#5d4400
    style ALS fill:#5d4400
    style FTD fill:#5d4400