protein

NSF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NSF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

102Connections
5Hypotheses
14Analyses
50Outgoing
34Incoming

Summary

NSF is a protein involved in neurodegeneration research. Key relationships include: associated with, regulates, interacts with. Associated with Als, Cancer, Glioma. Connected to 54 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolNSF
Full NameN-Ethylmaleimide Sensitive Fusion Protein
Chromosome17q21.31
FunctionNSF is a member of the AAA+ (ATPases Associated with diverse cellular Activities) protein family that functions as a molecular chaperone for SNARE complex recycling
Primary Expressionall eukaryotic cells, with high expression in neurons - Protein Complexes: Forms hexameric complexes and interacts with alpha
Molecular Weight66 kDa
PathwaysApoptosis, Cell Cycle
UniProt IDP46459
NCBI Gene ID4900
Ensembl IDENSG00000134574
OMIM163580
GeneCardsNSF
Human Protein AtlasNSF
DiseaseMechanism
Alzheimer's DiseaseImpaired SNARE function affects synaptic plasticity; Aβ oligomers disrupt NSF-mediated vesicle recycling
Associated Diseasesepilepsy
Known Drugs/Compoundsrapamycin
InteractionsRIPK1, SNAP25, AND, RNA, TRPML1, SNARE
KG Connections102 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: NSF — AlphaFold P46459 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

NSF Gene

gene · 612 words

GRIA3 Gene

gene · 5408 words

Autophagy Mechanisms

mechanism · 4866 words

Vesicle Trafficking Dysfunction in Corticobasal Syndrome

mechanism · 4859 words

omega-3-fatty-acids-neurodegeneration

therapeutic · 4551 words

Epigenetic-Metabolic Coupling: SIRT1 Activator + NAD+ Precursor

idea · 3877 words

Pathway Diagram

graph TD
    NSF["<b>NSF</b>"]
    Cancer{"Cancer"}
    NSF -->|"regulates"| Cancer
    Tumor{"Tumor"}
    NSF -->|"regulates"| Tumor
    Glioma{"Glioma"}
    NSF -->|"regulates"| Glioma
    Als{"Als"}
    NSF -->|"regulates"| Als
    Ms{"Ms"}
    NSF -->|"regulates"| Ms
    Stroke{"Stroke"}
    NSF -->|"interacts with"| Stroke
    LAMP1["LAMP1"]
    NSF -->|"associated with"| LAMP1
    ATG12["ATG12"]
    NSF -->|"associated with"| ATG12
    Mtor(["Mtor"])
    NSF -->|"associated with"| Mtor
    Autophagy(["Autophagy"])
    NSF -->|"associated with"| Autophagy
    GAPDH["GAPDH"]
    NSF -->|"associated with"| GAPDH
    STX17["STX17"]
    NSF -->|"associated with"| STX17
    VAMP8["VAMP8"]
    VAMP8 -->|"associated with"| NSF
    ULK1["ULK1"]
    ULK1 -->|"associated with"| NSF
    LC3["LC3"]
    LC3 -->|"associated with"| NSF
    MCOLN1["MCOLN1"]
    MCOLN1 -->|"associated with"| NSF
    GAPDH -->|"associated with"| NSF
    STX17 -->|"associated with"| NSF
    SQSTM1["SQSTM1"]
    SQSTM1 -->|"associated with"| NSF
    MAP1LC3["MAP1LC3"]
    MAP1LC3 -->|"associated with"| NSF
    P62["P62"]
    P62 -->|"associated with"| NSF
    ATG12 -->|"associated with"| NSF
    STX17 -->|"contributes to"| NSF
    MIRNAS["MIRNAS"]
    MIRNAS -->|"regulates"| NSF
    style NSF fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (68)

TargetRelationTypeStr
Cancerregulatesdisease0.65
Tumorregulatesdisease0.65
Gliomaregulatesdisease0.65
Alsregulatesdisease0.65
Msregulatesdisease0.65

Incoming (34)

SourceRelationTypeStr
VAMP8associated_withgene0.60
ULK1associated_withgene0.60
LC3associated_withgene0.60
MCOLN1associated_withgene0.60
GAPDHassociated_withgene0.60

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Magnetosonic-Triggered Transferrin Receptor Clustering 0.470 neurodegeneration Blood-brain barrier transport mechanisms
Mitochondrial Transfer Pathway Enhancement 0.443 neurodegeneration Astrocyte reactivity subtypes in neurode
CX43 hemichannel engineering enables size-selective mitochon 0.415 neurodegeneration Mitochondrial transfer between astrocyte
GAP43-mediated tunneling nanotube stabilization enhances neu 0.380 neurodegeneration Mitochondrial transfer between astrocyte
Optogenetic Control of Mitochondrial Transfer Networks 0.378 neurodegeneration Mitochondrial transfer between neurons a

Mentioning Analyses (14)

Scientific analyses that reference this entity

What are the specific circulating factors in exercise-conditioned plasma that me

neurodegeneration | 2026-04-14 | 2 hypotheses Top: 0.589

What is the relative contribution of connexin-43 gap junctions vs tunneling nano

cell biology | 2026-04-12 | 2 hypotheses Top: 0.579

What are the molecular determinants that control directional mitochondrial trans

cellular neuroscience | 2026-04-12 | 0 hypotheses

Do transferred mitochondria from diseased astrocytes carry pathological damage t

neurodegeneration | 2026-04-11 | 0 hypotheses

What is the therapeutic window between tau propagation inhibition and essential

neurodegeneration | 2026-04-06 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic t [PMID:32048886] Yao RQ, Ren C, Xia ZF, Yao YM Autophagy 2021 2
Astrocytic Connexin43 in Alzheimer's disease: mechanisms, interaction with P2 re [PMID:41062060] Xiong W, Su Y, Verkhratsky A, Yi C Neuropharmacology 2026 1
Connexin43 hemichannel blockade turns microglia neuroprotective and mitigates co [PMID:40595567] Su Y, Li H, Zhang W, Tao S, Wang Q, Zhan Nat Commun 2025 1
Miro1: A potential target for treating neurological disorders. [PMID:40403957] Zeng L, Yang J, Zhang C, Zhu J, Zhong S, Neuroscience 2025 1
Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease. [PMID:40425446] Sehlin D, Hultqvist G, Michno W, Aguilar J Prev Alzheimers Dis 2025 1
Should it stay or should it go: gap junction protein GJA1/Cx43 conveys damaged l [PMID:39394955] Domingues N, Ribeiro-Rodrigues T, Girão Autophagy 2024 1
Connexin 43 regulates intercellular mitochondrial transfer from human mesenchyma [PMID:39390589] Irwin RM, Thomas MA, Fahey MJ, Mayán MD, Stem Cell Res Ther 2024 1
Calcium-Associated Proteins in Neuroregeneration. [PMID:38397420] Lisek M, Tomczak J, Boczek T, Zylinska L Biomolecules 2024 1
Mitochondria from osteolineage cells regulate myeloid cell-mediated bone resorpt [PMID:38877020] Ding P, Gao C, Zhou J, Mei J, Li G, Liu Nat Commun 2024 1
Selective inhibition of cannabinoid CB(1) receptor-evoked signalling by the inte [PMID:37689260] Maroto IB, Moreno E, Costas-Insua C, Mer Neuropharmacology 2023 1
Effect of ferroptosis on chronic cerebral hypoperfusion in vascular dementia. [PMID:37709116] Fu P, Chen Y, Wu M, Bao B, Yin X, Chen Z Exp Neurol 2023 1
lncRNA LOC100911717-targeting GAP43-mediated sympathetic remodeling after myocar [PMID:36684596] Li P, Wang K, Yin J, Qi L, Hu H, Yang P, Front Cardiovasc Med 2022 1
Astrocyte Networks as Therapeutic Targets in Glaucomatous Neurodegeneration. [PMID:34199470] Boal AM, Risner ML, Cooper ML, Wareham L Cells 2021 1
Machine Learning and Novel Biomarkers for the Diagnosis of Alzheimer's Disease. [PMID:33803217] Chang CH, Lin CH, Lane HY Int J Mol Sci 2021 1
MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote qualit [PMID:34873283] König T, Nolte H, Aaltonen MJ, Tatsuta T Nat Cell Biol 2021 1
On Iron Metabolism and Its Regulation. [PMID:33925597] Vogt AS, Arsiwala T, Mohsen M, Vogel M, Int J Mol Sci 2021 1
Transferrin Receptor Is a Specific Ferroptosis Marker. [PMID:32160546] Feng H, Schorpp K, Jin J, Yozwiak CE, Ho Cell Rep 2020 1
Transferrin and transferrin receptors update. [PMID:29969719] Kawabata H Free Radic Biol Med 2019 1
Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal ste [PMID:24431222] Ahmad T, Mukherjee S, Pattnaik B, Kumar EMBO J 2014 1
Nerve growth cone motility. [PMID:2139335] Lankford K, Cypher C, Letourneau P Curr Opin Cell Biol 1990 1