protein

NSF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NSF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

110Connections

22Hypotheses

1Analyses

50Outgoing

38Incoming

20Experiments

1Debates

Summary

NSF is a protein involved in neurodegeneration research. Key relationships include: associated with, regulates, interacts with. Associated with Als, Cancer, Glioma. Connected to 54 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	NSF
Full Name	N-Ethylmaleimide Sensitive Fusion Protein
Chromosome	17q21.31
Function	NSF is a member of the AAA+ (ATPases Associated with diverse cellular Activities) protein family that functions as a molecular chaperone for SNARE complex recycling
Primary Expression	all eukaryotic cells, with high expression in neurons - Protein Complexes: Forms hexameric complexes and interacts with alpha
Molecular Weight	66 kDa
Pathways	Apoptosis, Cell Cycle
UniProt ID	P46459
NCBI Gene ID	4900
Ensembl ID	ENSG00000134574
OMIM	163580
GeneCards	NSF
Human Protein Atlas	NSF
Associated Diseases	epilepsy
Known Drugs/Compounds	rapamycin
Interactions	AMPK, AND, LC3, MAP1LC3, MTOR, MTORC1
KG Connections	110 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NSF — AlphaFold P46459 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NSF["NSF"]
    Cancer{"Cancer"}
    NSF -->|"regulates"| Cancer
    Tumor{"Tumor"}
    NSF -->|"regulates"| Tumor
    Glioma{"Glioma"}
    NSF -->|"regulates"| Glioma
    Als{"Als"}
    NSF -->|"regulates"| Als
    Ms{"Ms"}
    NSF -->|"regulates"| Ms
    Stroke{"Stroke"}
    NSF -->|"interacts with"| Stroke
    LAMP1["LAMP1"]
    NSF -->|"associated with"| LAMP1
    ATG12["ATG12"]
    NSF -->|"associated with"| ATG12
    Mtor(["Mtor"])
    NSF -->|"associated with"| Mtor
    Autophagy(["Autophagy"])
    NSF -->|"associated with"| Autophagy
    GAPDH["GAPDH"]
    NSF -->|"associated with"| GAPDH
    STX17["STX17"]
    NSF -->|"associated with"| STX17
    VAMP8["VAMP8"]
    VAMP8 -->|"associated with"| NSF
    ULK1["ULK1"]
    ULK1 -->|"associated with"| NSF
    LC3["LC3"]
    LC3 -->|"associated with"| NSF
    MCOLN1["MCOLN1"]
    MCOLN1 -->|"associated with"| NSF
    GAPDH -->|"associated with"| NSF
    STX17 -->|"associated with"| NSF
    SQSTM1["SQSTM1"]
    SQSTM1 -->|"associated with"| NSF
    MAP1LC3["MAP1LC3"]
    MAP1LC3 -->|"associated with"| NSF
    P62["P62"]
    P62 -->|"associated with"| NSF
    ATG12 -->|"associated with"| NSF
    STX17 -->|"contributes to"| NSF
    MIRNAS["MIRNAS"]
    MIRNAS -->|"regulates"| NSF
    style NSF fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (72)

Target	Relation	Type	Str
SNARE complex disassembly	regulates	phenotype	0.90
synaptic vesicle recycling	activates	phenotype	0.90
SNCA	expresses	gene	0.70
Tumor	regulates	disease	0.65
Ms	biomarker_for	disease	0.65
Glioma	regulates	disease	0.65
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Stroke	interacts_with	disease	0.65
Neuroinflammation	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Cancer	regulates	disease	0.65
CD8	biomarker_for	gene	0.60
ULK1	associated_with	gene	0.60
Rb	regulates	protein	0.60
cancer	activates	disease	0.60
epilepsy	associated_with	disease	0.60
epilepsy	causes	disease	0.60
stroke	interacts_with	disease	0.60
Mtor	associated_with	pathway	0.60
Cell Cycle	regulates	pathway	0.60
Apoptosis	regulates	pathway	0.60
Necroptosis	interacts_with	pathway	0.60
MAP1LC3	associated_with	gene	0.60
MTORC1	associated_with	gene	0.60
CANCER	regulates	gene	0.60
LYSOSOME	regulates	gene	0.60
NEUROINFLAMMATION	biomarker_for	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
GENES	biomarker_for	gene	0.60
IMMUNE INFILTRATION	biomarker_for	gene	0.60
MITOCHONDRIAL DYSFUNCTION	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
SNARE	activates	gene	0.60
ATG12	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
STX17	associated_with	gene	0.60
MCOLN1	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
LC3	associated_with	gene	0.60
RIPK1	interacts_with	gene	0.60
SQSTM1	associated_with	gene	0.60
P62	activates	entity	0.60
SQSTM1	activates	entity	0.60
STX17	activates	entity	0.60
ULK1	activates	entity	0.60
VAMP8	activates	entity	0.60

Incoming (38)

Source	Relation	Type	Str
KEAP1	expresses	gene	0.70
AUTOPHAGY	regulates	pathway	0.60
AUTOPHAGY	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
LYSOSOME	regulates	gene	0.60
MTORC1	associated_with	gene	0.60
RNA	associated_with	gene	0.60
TRPML1	associated_with	gene	0.60
MAP1LC3	activates	gene	0.60
MTORC1	activates	gene	0.60
rapamycin	targets	drug	0.60
LC3	activates	gene	0.60
MITOPHAGY	protects_against	pathway	0.60
VAMP8	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
MCOLN1	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
P62	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
LAMP1	regulates	gene	0.60
LC3	regulates	gene	0.60
MTOR	regulates	gene	0.60
ATG12	activates	entity	0.60
GAPDH	activates	entity	0.60
LAMP1	activates	entity	0.60
MCOLN1	activates	entity	0.60
AMPK	activates	gene	0.60
AUTOPHAGY	activates	pathway	0.60
MTOR	interacts_with	gene	0.60
ATG12	associated_with	gene	0.60
MIRNAS	regulates	gene	0.60
CANCER	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
MICRORNAS	regulates	gene	0.60
STX17	associated_with	gene	0.60
NECROPTOSIS	co_discussed	pathway	0.40

Targeting Hypotheses (22)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
pH-Sensitive Bispecific Antibody Targeting Transferrin Recep	0.800	neurodegeneration	Blood-brain barrier antibody transport m
Magnetosonic-Triggered Transferrin Receptor Clustering	0.719	neurodegeneration	Blood-brain barrier transport mechanisms
Mitochondrial Transfer Pathway Enhancement	0.695	neurodegeneration	Astrocyte reactivity subtypes in neurode
Endosomal escape determines whether transferred tau becomes	0.694	neurodegeneration	Seed-competent tau conformers in trans-s
GAP43-mediated tunneling nanotube stabilization enhances neu	0.666	neurodegeneration	Mitochondrial transfer between astrocyte

whether the Mitochondrial transfer between neurons and glia	0.604	neurodegeneration	Methodology challenge: notebook 'Mitocho
whether the Mitochondrial transfer between neurons and glia	0.604	neurodegeneration	Methodology challenge: notebook 'Mitocho
Stratified falsifiers should govern Methodology challenge: n	0.591	neurodegeneration	Methodology challenge: notebook 'Mitocho
Stratified falsifiers should govern Methodology challenge: n	0.591	neurodegeneration	Methodology challenge: notebook 'Mitocho
Mitochondrial transfer between neurons and glia — Rich Analy	0.577	neurodegeneration	Methodology challenge: notebook 'Mitocho
Mitochondrial transfer between neurons and glia — Rich Analy	0.577	neurodegeneration	Methodology challenge: notebook 'Mitocho
CX43 hemichannel engineering enables size-selective mitochon	0.566	neurodegeneration	Mitochondrial transfer between astrocyte
Extracellular Vesicle Cargo Transfer	0.480	neurodegeneration	Which specific factors in conditioned me
Optogenetic Control of Mitochondrial Transfer Networks	0.476	neurodegeneration	Mitochondrial transfer between neurons a
Glycosyltransferase Modulation for Tau Vesicle Marking	0.455	neurodegeneration	Do tau-containing vesicles exhibit uniqu
Transferrin-Alectinib Conjugation Enhances Blood-Brain Barri	0.406	molecular-biology	Does Alectinib truly bind C1q directly w
Astrocyte CD38-erk Mapk signaling controls mitochondrial tra	0.380	als-and-alzheimers	Mitochondrial transfer between neurons a
Enhancing Heparan Sulfate 3-O-Sulfotransferase Activity to C	0.380	neuroscience	Trans-synaptic tau spreading and propaga
Synthesis and Constructive Resolution Toward Methodological	0.000	-	-
Statistical Underpowering and the Reproducibility Crisis in	0.000	-	-
Exosomal Autophagosome Transfer System	0.000	-	How do non-cell autonomous effects of au
Mitochondrial Transfer Enhancers for Synaptic Dysfunction	0.000	-	Mitochondrial transfer between astrocyte

Mentioning Analyses (1)

Scientific analyses that reference this entity

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-02 | 0 hypotheses

Experiments (20)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Autophagy receptor identification for stress granule elimination	exploratory	neurodegenerative diseases	0.900	0.00	cultured cells under arsenite	proposed	N/A
iPSC-derived endothelial cell iron uptake with RLS CSF exposure	exploratory	restless legs syndrome	0.900	0.00	iPSC-derived human endothelial	proposed	N/A
s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice with engin	falsification	Neuroinflammation	0.400	0.50	mouse	proposed	$200,000
s:** - Compare uptake with/without magnetic particles using tight junc	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$120,000
AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Therapy	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000
AAV Serotype Comparison for LRRK2 Knockdown in PD	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000
s:** - Test MCU overexpression specifically in layer II neurons in hea	falsification	Neurodegeneration	0.400	0.50	mouse	proposed	$200,000
Proposed experiment from debate on Mitochondrial transfer between astr	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Proposed experiment from debate on Mitochondrial transfer between astr	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$100,000
Mechanism: Selective Vulnerability of Dopaminergic Neurons in Parkinso	validation	Parkinson's Disease	0.400	0.50	human	proposed	$3,000,000
Selective Vulnerability of Dopaminergic Neurons — Mechanism and Protec	validation	Neurodegeneration	0.400	0.50	cell_line	proposed	$160,000
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment Design	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,500,000
Exercise-BDNF-Mitophagy Biomarker Study in PD	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Ferroptosis Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
GLP-1 Agonist Neuroprotection Mechanism in PD	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Cytochrome Therapeutics	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Axonal Transport Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Gap Junction Dysfunction Validation in Parkinson's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Selective Neuronal Vulnerability to Aging — Mapping Why Specific Neuro	validation	Neurodegeneration	0.400	0.50	human	proposed	$3,000,000
Synaptic Mitochondrial Resilience Enhancement for Parkinson's Disease	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic t [PMID:32048886]	Yao RQ, Ren C, Xia ZF, Yao YM	Autophagy	2021	2
Miro1: A potential target for treating neurological disorders. [PMID:40403957]	Zeng L, Yang J, Zhang C, Zhu J, Zhong S,	Neuroscience	2025	1
Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease. [PMID:40425446]	Sehlin D, Hultqvist G, Michno W, Aguilar	J Prev Alzheimers Dis	2025	1
Calcium-Associated Proteins in Neuroregeneration. [PMID:38397420]	Lisek M, Tomczak J, Boczek T, Zylinska L	Biomolecules	2024	1
Mitochondria from osteolineage cells regulate myeloid cell-mediated bone resorpt [PMID:38877020]	Ding P, Gao C, Zhou J, Mei J, Li G, Liu	Nat Commun	2024	1
Effect of ferroptosis on chronic cerebral hypoperfusion in vascular dementia. [PMID:37709116]	Fu P, Chen Y, Wu M, Bao B, Yin X, Chen Z	Exp Neurol	2023	1
Selective inhibition of cannabinoid CB(1) receptor-evoked signalling by the inte [PMID:37689260]	Maroto IB, Moreno E, Costas-Insua C, Mer	Neuropharmacology	2023	1
lncRNA LOC100911717-targeting GAP43-mediated sympathetic remodeling after myocar [PMID:36684596]	Li P, Wang K, Yin J, Qi L, Hu H, Yang P,	Front Cardiovasc Med	2022	1
Machine Learning and Novel Biomarkers for the Diagnosis of Alzheimer's Disease. [PMID:33803217]	Chang CH, Lin CH, Lane HY	Int J Mol Sci	2021	1
On Iron Metabolism and Its Regulation. [PMID:33925597]	Vogt AS, Arsiwala T, Mohsen M, Vogel M,	Int J Mol Sci	2021	1
MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote qualit [PMID:34873283]	König T, Nolte H, Aaltonen MJ, Tatsuta T	Nat Cell Biol	2021	1
Transferrin Receptor Is a Specific Ferroptosis Marker. [PMID:32160546]	Feng H, Schorpp K, Jin J, Yozwiak CE, Ho	Cell Rep	2020	1
Transferrin and transferrin receptors update. [PMID:29969719]	Kawabata H	Free Radic Biol Med	2019	1
Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal ste [PMID:24431222]	Ahmad T, Mukherjee S, Pattnaik B, Kumar	EMBO J	2014	1
Nerve growth cone motility. [PMID:2139335]	Lankford K, Cypher C, Letourneau P	Curr Opin Cell Biol	1990	1
L-Carnitine and Acetyl-L-Carnitine in Drug Poisonings: A Systematic Review of Cl [PMID:41692009]	["Rezaee H", "Abbasgholizadeh F"]	Journal of applied toxicology	2026	0
Time- and dose-dependent effects of bacterial infection on iron metabolism, infl [PMID:41619877]	Lu Y, Zhang Y, Niu C	Comp Biochem Physiol A Mol Int	2026	0
Ayanin combats against barium sulphate nanoparticles induced hepatotoxicity via [PMID:41666660]	Zhu D, Lu Y, Jamil S, Ashfaq H, Al-Emam	J Trace Elem Med Biol	2026	0
The synergistic effects of UV-328 and polystyrene microplastics on zebrafish emb [PMID:41771220]	Yang X, Liao X, Zhong L, Lin M, Zhang M	Aquat Toxicol	2026	0
Role of iron and TfR1 in the application of high‑dose ascorbate against pancreat [PMID:41789665]	Piotrowsky A, Leischner C, Schmieder H,	Oncol Rep	2026	0

Debates (1)

Multi-agent debates referencing this entity

What are the mechanisms by which tau pathology spreads through connected brain r

closed · Rounds: 4 · Score: 0.50 · 2026-04-20

Related Research

Hypotheses and analyses mentioning NSF in their description or question text

NSF

Understanding Entity Pages

Summary

Wiki Pages (4)

NSF Gene

NAPA — NSF Attachment Protein Alpha

NSF Protein

alpha-SNAP Protein (NSF Attachment Protein Alpha)

Pathway Diagram

Outgoing (72)

Incoming (38)

Targeting Hypotheses (22)

Mentioning Analyses (1)

Tau propagation mechanisms and therapeutic interception points

Experiments (20)

Related Papers (20)

Debates (1)

What are the mechanisms by which tau pathology spreads through connected brain r

Related Research

whether the Mitochondrial transfer between neurons and glia — Rich Analysis Note

whether the Mitochondrial transfer between neurons and glia — Rich Analysis Note

Stratified falsifiers should govern Methodology challenge: notebook 'Mitochondri

Stratified falsifiers should govern Methodology challenge: notebook 'Mitochondri

Mitochondrial transfer between neurons and glia — Rich Analysis Notebook should

Mitochondrial transfer between neurons and glia — Rich Analysis Notebook should

CX43 hemichannel engineering enables size-selective mitochondrial transfer

Extracellular Vesicle Cargo Transfer

Optogenetic Control of Mitochondrial Transfer Networks

Glycosyltransferase Modulation for Tau Vesicle Marking

Transferrin-Alectinib Conjugation Enhances Blood-Brain Barrier Transport via Tra

Astrocyte CD38-erk Mapk signaling controls mitochondrial transfer to neurons via

Enhancing Heparan Sulfate 3-O-Sulfotransferase Activity to Competitively Block T