Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PURINERGIC SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | PURINERGIC SIGNALING |
| Related Diseases | DIABETES |
| Linked Hypotheses | 4 hypotheses |
Knowledge base pages for this entity
graph TD
PURINERGIC_SIGNALING["PURINERGIC SIGNALING"]
PURINERGIC_SIGNALING -->|"involved_in"| Neuro_immune_Cell_Functions["Neuro-immune Cell Functions"]
PURINERGIC_SIGNALING -->|"correlates_with"| Coagulation["Coagulation"]
PURINERGIC_SIGNALING -->|"expressed in"| Leukocyte["Leukocyte"]
PURINERGIC_SIGNALING -->|"regulates"| PANCREATIC_B_CELL_FUNCTION["PANCREATIC B-CELL FUNCTION"]
PURINERGIC_SIGNALING -->|"regulates"| GLUCOSE_REGULATION["GLUCOSE REGULATION"]
PURINERGIC_SIGNALING -.protects against.-> SYNAPSE["SYNAPSE"]
ATP["ATP"] -->|"involved_in"| PURINERGIC_SIGNALING
NAD_["NAD+"] -->|"involved_in"| PURINERGIC_SIGNALING
ADP["ADP"] -->|"activates"| PURINERGIC_SIGNALING
Adenosine["Adenosine"] -->|"activates"| PURINERGIC_SIGNALING
P2RY1["P2RY1"] -->|"participates in"| PURINERGIC_SIGNALING
P2RX7["P2RX7"] -->|"participates in"| PURINERGIC_SIGNALING
B_CELLS["B CELLS"] -->|"regulates"| PURINERGIC_SIGNALING| Target | Relation | Type | Str |
|---|---|---|---|
| PANCREATIC B-CELL FUNCTION | regulates | entity | 0.85 |
| GLUCOSE REGULATION | regulates | entity | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Purinergic Signaling Polarization Control | 0.554 | neurodegeneration | Astrocyte reactivity subtypes in neurode |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Purinergic signaling elements are correlated with coagulation players in periphe [PMID:35091759] | Schultz IC, Bertoni APS, Wink MR | J Mol Med (Berl) | 2022 | 1 |
| Purinergic Receptors in the Airways: Potential Therapeutic Targets for Asthma? [PMID:35386996] | Thompson RJ, Sayers I, Kuokkanen K, Hall | Front Allergy | 2021 | 1 |
| Variation in glucose homeostasis traits associated with P2RX7 polymorphisms in m [PMID:25719930] | Todd JN, Poon W, Lyssenko V, Groop L, Ni | J Clin Endocrinol Metab | 2015 | 1 |
| CSF ATP levels correlate with Alzheimer's disease severity and predict progressi [PMID:synthetic_4] | Unknown | JAMA Neurol | 2024 | 0 |
| Astrocyte phenotype switching controlled by purinergic receptor balance regulate [PMID:synthetic_1] | Unknown | Nature Neuroscience | 2023 | 0 |
| P2Y1 agonist enhances astrocyte-mediated neuroprotection via BDNF upregulation [PMID:synthetic_3] | Unknown | Glia | 2023 | 0 |
| Astrocyte phenotype heterogeneity may not fit simple A1/A2 binary classification [PMID:synthetic_8] | Unknown | Cell | 2023 | 0 |
| P2X7 antagonists failed to show efficacy in depression trials despite target eng [PMID:synthetic_6] | Unknown | Mol Psychiatry | 2022 | 0 |
| P2X7 antagonist reduces amyloid pathology and preserves cognition in APP/PS1 mic [PMID:synthetic_2] | Unknown | Neurobiol Dis | 2022 | 0 |
| JNJ-47965567 P2X7 antagonist shows CNS penetration and safety in Phase 2 trial [PMID:synthetic_5] | Unknown | Lancet Psychiatry | 2021 | 0 |
| P2Y1 agonists cause platelet activation and thrombotic risk in cardiovascular mo [PMID:synthetic_7] | Unknown | Thromb Haemost | 2020 | 0 |
| Functional coordination and HuR-mediated regulation of mRNA stability during T c [PMID:26490963] | ["Blackinton J", "Keene J"] | Nucleic acids research | 2016 | 0 |
| Characterization of a novel function-blocking antibody targeted against the plat [PMID:25593131] | ["Karim Z", "Vemana H", "Alshbool F", "L | Arteriosclerosis, thrombosis, | 2015 | 0 |
| Dysregulation of leukocyte gene expression in women with medication-refractory d [PMID:24143878] | Iacob E, Light KC, Tadler SC, Weeks HR, | BMC psychiatry | 2013 | 0 |
| Evidence of HPV subtypes linked with cervical cancer in Nepal. [PMID:28615609] | ["Bhusal C", "Manandhar S", "Singh M", " | WHO South-East Asia journal of | 2012 | 0 |
| Purinergic receptors are part of a functional signaling system for proliferation [PMID:12787128] | Greig AV, Linge C, Terenghi G, McGrouthe | The Journal of investigative d | 2003 | 0 |