concept

WT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

123Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	WT1
Summary	Wilms' tumor 1 (WT1) protein-expressing neurons in the brain - their role in development, function, and neurodegenerative diseases including Alzheimer's and Parkinson's.
Key Genes/Proteins	ACTB, AUTOPHAGY, AND, MAP3K5, STK11, P62
Related Diseases	High-Grade Serous Ovarian Cancer, ALS, Als, Cancer
Related Pathways	RAS pathway genes

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    WT1["WT1"]
    WT1 -.biomarker for.-> High_Grade_Serous_Ovarian_Canc["High-Grade Serous Ovarian Cancer"]
    WT1 -->|"expressed in"| ALS["ALS"]
    WT1 -->|"expressed in"| Als["Als"]
    WT1 -.biomarker for.-> Cancer["Cancer"]
    WT1 -->|"regulates"| ACTB["ACTB"]
    WT1 -->|"regulates"| AUTOPHAGY["AUTOPHAGY"]
    GJA1["GJA1"] -->|"regulates"| WT1
    LYSOSOME["LYSOSOME"] -->|"regulates"| WT1
    ATG14["ATG14"] -->|"regulates"| WT1
    GAPDH["GAPDH"] -->|"regulates"| WT1
    CASP3["CASP3"] -->|"regulates"| WT1
    BECN1["BECN1"] -->|"regulates"| WT1
    H2AX["H2AX"] -->|"regulates"| WT1
    AND["AND"] -->|"expressed in"| WT1

Outgoing (63)

Target	Relation	Type	Str
High-Grade Serous Ovarian Cancer	biomarker_for	disease	0.85
ALS	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Als	biomarker_for	disease	0.65
Cancer	biomarker_for	disease	0.65
ALS	biomarker_for	disease	0.65
ACTB	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
AND	associated_with	gene	0.60
MAP3K5	associated_with	gene	0.60
STK11	associated_with	gene	0.60
P62	associated_with	gene	0.60
TUBB3	associated_with	gene	0.60
CDC42	regulates	gene	0.60
PIK3C3	associated_with	gene	0.60
TJP1	associated_with	gene	0.60
OCLN	associated_with	gene	0.60
RAC1	associated_with	gene	0.60
Autophagy	regulates	pathway	0.60
Ubiquitin-Proteasome	regulates	pathway	0.60
Proteasome	regulates	pathway	0.60
PAX2	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
CASP3	regulates	gene	0.60
LAMP1	associated_with	gene	0.60
SCIN	associated_with	gene	0.60
H2AX	regulates	gene	0.60
GJA1	regulates	gene	0.60
Stem Cell	associated_with	cell_type	0.60
Epithelial	expressed_in	cell_type	0.60
P16	biomarker_for	gene	0.60
AND	biomarker_for	gene	0.60
CANCER	biomarker_for	gene	0.60
P53	biomarker_for	gene	0.60
ATG14	regulates	gene	0.60
VIMENTIN	associated_with	gene	0.60
TUBULIN	associated_with	gene	0.60
BECN1	regulates	gene	0.60
Actin	regulates	protein	0.60
Tubulin	associated_with	protein	0.60
Caspase	regulates	protein	0.60
SALL1	associated_with	gene	0.60
Podocyte	expressed_in	cell_type	0.60
GAPDH	regulates	gene	0.60
CYP11A1	regulates	gene	0.60
UBIQUITIN	associated_with	gene	0.60
UVRAG	associated_with	gene	0.60
ERBB2	expressed_in	gene	0.60
FOSB	expressed_in	gene	0.60
CAMK2G	expressed_in	gene	0.60

Incoming (60)

Source	Relation	Type	Str
RAS pathway genes	associated_with	pathway	0.75
LAMP1	associated_with	gene	0.60
GJA1	regulates	gene	0.60
TUBULIN	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
VIMENTIN	associated_with	gene	0.60
VIM	associated_with	gene	0.60
LYSOSOME	regulates	gene	0.60
SQSTM1	associated_with	gene	0.60
ATG14	regulates	gene	0.60
SCIN	associated_with	gene	0.60
GAPDH	regulates	gene	0.60
UVRAG	associated_with	gene	0.60
CASP3	regulates	gene	0.60
BECN1	regulates	gene	0.60
H2AX	regulates	gene	0.60
SALL1	associated_with	gene	0.60
AND	expressed_in	gene	0.60
STK11	associated_with	gene	0.60
RAC1	associated_with	gene	0.60
TJP1	associated_with	gene	0.60
OCLN	associated_with	gene	0.60
TUBB3	associated_with	gene	0.60
AUTOPHAGY	regulates	gene	0.60
PIK3C3	associated_with	gene	0.60
CDC42	regulates	gene	0.60
P53	biomarker_for	gene	0.60
PAX2	associated_with	gene	0.60
P16	biomarker_for	gene	0.60
CANCER	biomarker_for	gene	0.60
FOS	expressed_in	gene	0.60
MYC	associated_with	gene	0.60
ACTB	activates	gene	0.60
AR	activates	gene	0.60
ATG14	activates	gene	0.60
BECN1	activates	gene	0.60
CASP3	activates	gene	0.60
CDC42	activates	gene	0.60
CYP11A1	activates	gene	0.60
GAPDH	activates	gene	0.60
GJA1	activates	gene	0.60
H2AX	activates	gene	0.60
HDAC6	activates	gene	0.60
LAMP1	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
MAP3K5	activates	gene	0.60
OCLN	activates	gene	0.60
PIK3C3	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

WT1

Understanding Entity Pages

Wiki Pages (7)

WT1-Expressing Neurons

Wellcome Trust

sall1

PAX2 Gene

DHH — Desert Hedgehog