concept

INSULIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INSULIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

908Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	INSULIN
Key Genes/Proteins	3r-tau, 4r-tau, ACTB, AKT, AKT2, ALZHEIMER
Related Diseases	aging, ALS, Alzheimer'S Disease, ALZHEIMER'S DISEASE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Insulin Signaling in Parkinson's Disease

mechanism · 4072 words

→

Pathway Diagram

graph TD
    INSULIN["INSULIN"]
    INSULIN -->|"activates"| TUG["TUG"]
    INSULIN -->|"regulates"| blood_glucose_levels["blood glucose levels"]
    INSULIN -->|"regulates"| glucose_metabolism["glucose metabolism"]
    INSULIN -->|"activates"| neuron_outgrowth["neuron outgrowth"]
    INSULIN -->|"activates"| Insulin_receptor["Insulin receptor"]
    MTOR["MTOR"] -->|"activates"| INSULIN
    APOPTOSIS["APOPTOSIS"] -->|"inhibits"| INSULIN
    AKT["AKT"] -->|"activates"| INSULIN
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| INSULIN
    EGFR["EGFR"] -->|"activates"| INSULIN
    SQSTM1["SQSTM1"] -->|"activates"| INSULIN
    PI3K["PI3K"] -->|"mediates"| INSULIN
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"regulates"| INSULIN

Outgoing (271)

Target	Relation	Type	Str
TUG	activates	entity	0.95
TUG	activates	protein	0.95
Glucose Uptake	regulates	process	0.90
Food Intake	regulates	process	0.90
EAAT1	upregulates	protein	0.90
AKT	activates	protein	0.90
EAAT2	upregulates	protein	0.90
blood glucose levels	regulates	phenotype	0.90
glucose storage	associated_with	phenotype	0.90
Oxidative Stress	treats	process	0.85
PI3K	activates	pathway	0.85
Alzheimer'S Disease	treats	disease	0.80
NEURODEGENERATION	treats	disease	0.80
IDE	upregulates	protein	0.80
NEURODEGENERATION	regulates	disease	0.80
TUG	stimulates	protein	0.80
neuron outgrowth	activates	process	0.70
Alzheimer's disease	associated_with	disease	0.70
Insulin receptor	activates	protein	0.70
glucose metabolism	regulates	process	0.70
Als	activates	disease	0.60
Necroptosis	inhibits	disease	0.60
Cancer	activates	disease	0.60
Huntington	expressed_in	disease	0.60
Pyroptosis	inhibits	disease	0.60
Parkinson	expressed_in	disease	0.60
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.60
Als	expressed_in	disease	0.60
Ferroptosis	inhibits	disease	0.60
Fibrosis	inhibits	disease	0.60
Aging	biomarker_for	disease	0.60
Cancer	interacts_with	disease	0.60
Diabetes	therapeutic_target	disease	0.60
Als	interacts_with	disease	0.60
Als	therapeutic_target	disease	0.60
Obesity	regulates	disease	0.60
Als	regulates	disease	0.60
Neuroinflammation	regulates	disease	0.60
Alzheimer	expressed_in	disease	0.60
Diabetes	regulates	disease	0.60
Aging	activates	disease	0.60
Fibrosis	regulates	disease	0.60
Aging	regulates	disease	0.60
Atherosclerosis	therapeutic_target	disease	0.60
Obesity	therapeutic_target	disease	0.60
Fibrosis	activates	disease	0.60
Hypertension	biomarker_for	disease	0.60
Aging	expressed_in	disease	0.60
Diabetes	activates	disease	0.60
Obesity	activates	disease	0.60

Incoming (637)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
PARKINSON'S DISEASE	associated_with	disease	1.00
AMYLOID	associated_with	protein	1.00
30795555	regulates	paper	0.90
AMPK	associated_with	gene	0.90
BDNF	associated_with	gene	0.82
TNF	associated_with	gene	0.82
IL-6	associated_with	gene	0.82
MTOR	associated_with	gene	0.82
NF-KB	associated_with	protein	0.82
MTOR	activates	gene	0.82
AMPK	activates	gene	0.74
AKT	activates	gene	0.74
TAU	associated_with	protein	0.72
AMYLOID	inhibits	protein	0.66
SOD1	associated_with	gene	0.66
AKT	associated_with	gene	0.66
APOE	associated_with	gene	0.66
PI3K	inhibits	gene	0.66
RNA	regulates	gene	0.60
ROS	regulates	gene	0.60
HSPG2	regulates	gene	0.60
29453413	part of shared mechanisms linking	paper	0.60
CERS2	regulates	gene	0.60
CAT	regulates	gene	0.60
PAQR4	activates	gene	0.60
PPARA	regulates	gene	0.60
IGF1R	regulates	gene	0.60
MTOR	regulates	gene	0.60
DAG1	regulates	gene	0.60
AGING	regulates	gene	0.60
CLOCK	therapeutic_target	gene	0.60
ACTB	regulates	gene	0.60
RAS	regulates	gene	0.60
P2RY1	associated_with	gene	0.60
LAMP1	regulates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
EIF4EBP1	regulates	gene	0.60
CPT1A	regulates	gene	0.60
P2RX7	activates	gene	0.60
GLUT4	activates	gene	0.60
SREBF1	regulates	gene	0.60
NADH	regulates	gene	0.60
CTSD	regulates	gene	0.60
PPARG	regulates	gene	0.60
RAB7A	regulates	gene	0.60
PPAR	activates	gene	0.60
PPARGC1A	regulates	gene	0.60
P2X7	associated_with	gene	0.60
ARNTL	regulates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Brain Insulin Resistance with Glucose Transporter Dysfunctio	0.596	neurodegeneration	Metabolic reprogramming in neurodegenera
Brain Insulin Resistance and Metabolic Dysregulation	0.480	neurodegeneration	Cross-disease neurodegeneration mechanis

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (9)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Comparative study of the glucolipid profile and GLUTs gene expression in respons [PMID:41232212]	["Wang Z", "Wang H", "Du P", "Zhang X",	Poultry science	2025
Altered Glut4, IRAP, and Brain Insulin Signaling in a Mouse Model of Epilepsy an [PMID:41369048]	["Xu W", "Neal E", "Barlow N", "Thompson	Journal of neurochemistry	2025
Targeting glucose transporters in parkinson's disease: a novel metabolic approac [PMID:40879857]	["Singh G", "Ansari S", "Aran K"]	Metabolic brain disease	2025
Tirzepatide prevents neurodegeneration through multiple molecular pathways. [PMID:38287296]	Fontanella RA, Ghosh P, Pesapane A, Takt	Journal of translational medic	2024
A high fat diet potentiates neonatal iron overload-induced memory impairments in [PMID:38358514]	["do Nascimento F", "de Freitas B", "Dos	European journal of nutrition	2024
[WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268]	Wieschollek S, Forster S, Megerle K	Handchirurgie, Mikrochirurgie,	2022
Complete Genome Sequence of Geobacter sp. Strain FeAm09, a Moderately Acidophili [PMID:33446582]	Yadav P, Antony-Babu S, Hayes E, Healy O	Microbiology resource announce	2021
Engineering complex communities by directed evolution. [PMID:33986540]	Chang CY, Vila JCC, Bender M, Li R, Mank	Nature ecology & evolution	2021
Successful Nonoperative Treatment of Osteochondritis Dissecans of the Humeral Ca [PMID:34825100]	Tajika T, Kuboi T, Endo F, Hatori Y, Sai	Progress in rehabilitation med	2021

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning INSULIN in their description or question text

No additional research found