pathway

P38 Mapk

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P38 Mapk: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

272Connections

0Hypotheses

0Analyses

42Outgoing

50Incoming

No summary available yet. View on Wiki →

🔀 Pathway Info

Name	P38 Mapk
Key Genes/Proteins	P38, INFLAMMATION, ERK, IL-6, CANCER, APOPTOSIS
Related Diseases	Inflammation, Als, Tumor, Cancer

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    P38_Mapk["P38 Mapk"] -->|"regulates"| Dermatomyositis["Dermatomyositis"]
    style Dermatomyositis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    P38_Mapk["P38 Mapk"] -->|"regulates"| Adult_Dermatomyositis["Adult Dermatomyositis"]
    style Adult_Dermatomyositis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    P38_Mapk["P38 Mapk"] -->|"involved in"| Neurodegeneration["Neurodegeneration"]
    style Neurodegeneration fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    P38_Mapk["P38 Mapk"] -->|"regulates"| PIEZO1["PIEZO1"]
    style PIEZO1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    P38_Mapk["P38 Mapk"] -->|"activates"| Apoptosis["Apoptosis"]
    style Apoptosis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    P38_Mapk["P38 Mapk"] -->|"regulates"| inflammation["inflammation"]
    style inflammation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    P38_Mapk["P38 Mapk"] -->|"activates"| tau_phosphorylation["tau phosphorylation"]
    style tau_phosphorylation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    P38["P38"] -->|"activates"| P38_Mapk["P38 Mapk"]
    style P38 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    INFLAMMATION["INFLAMMATION"] -->|"activates"| P38_Mapk["P38 Mapk"]
    style INFLAMMATION fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    IGF2BP1["IGF2BP1"] -->|"binds"| P38_Mapk["P38 Mapk"]
    style IGF2BP1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ERK["ERK"] -->|"activates"| P38_Mapk["P38 Mapk"]
    style ERK fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    IL_6["IL-6"] -->|"activates"| P38_Mapk["P38 Mapk"]
    style IL_6 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style P38_Mapk fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (55)

Target	Relation	Type	Str
Neurodegeneration	involved_in	process	0.85
GABARAP	activates	protein	0.50
GRP78	activates	protein	0.50
VPS34	activates	protein	0.50
IFNG	activates	gene	0.50
cancer	activates	disease	0.50
MAPK	activates	gene	0.50
OXIDATIVE PHOSPHORYLATION	activates	pathway	0.50
MTORC1	activates	concept	0.50
Stem Cell	activates	cell_type	0.50
Epithelial Cell	activates	cell_type	0.50
disease	activates	disease	0.50
Dendritic Cell	activates	cell_type	0.50
CYP1A1	activates	concept	0.50
DNA DAMAGE	activates	concept	0.50
COLORECTAL CANCER	activates	disease	0.50
Microrna	activates	pathway	0.50
Inflammatory Bowel Disease	activates	disease	0.50
Reactive Oxygen Species	activates	process	0.50
RAPAMYCIN	activates	concept	0.50
NUCLEUS	activates	concept	0.50
ENDOPLASMIC RETICULUM	activates	concept	0.50
PEROXISOME	activates	concept	0.50
MAPK	regulates	gene	0.50
Pi3K/Akt	regulates	pathway	0.50
MAPK SIGNALING	regulates	concept	0.50
TUMOR	associated_with	disease	0.50
ALZHEIMER	associated_with	gene	0.50
MAPK	associated_with	gene	0.50
Alzheimer'S Disease	associated_with	disease	0.50
CYTOKINES	associated_with	concept	0.50
Astrocytes	associated_with	cell_type	0.50
Astrocyte	associated_with	cell_type	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
CYTOKINE	associated_with	concept	0.50
apoptosis	activates	process	0.50
MAPK SIGNALING	activates	concept	0.50
CD2AP	activates	protein	0.50
ALZHEIMER	activates	gene	0.50
Alzheimer'S Disease	activates	disease	0.50
ALZHEIMER'S	activates	concept	0.50

Incoming (217)

Source	Relation	Type	Str
P38	activates	gene	1.00
INFLAMMATION	activates	gene	0.90
Inflammation	activates	disease	0.90
P38	contributes_to	gene	0.80
ERK	activates	gene	0.80
IL-6	activates	gene	0.80
Als	activates	disease	0.80
CANCER	activates	gene	0.70
Tumor	activates	disease	0.70
Cancer	activates	disease	0.70
APOPTOSIS	activates	gene	0.70
NEUROTOXICITY	activates	gene	0.70
JNK	activates	gene	0.70
CYTOKINES	activates	gene	0.70
JUN	activates	gene	0.70
TNF	activates	gene	0.70
TNF-Α	activates	gene	0.70
NEUROINFLAMMATION	activates	gene	0.70
Neuroinflammation	activates	disease	0.70
ALZHEIMER	activates	gene	0.70
ALZHEIMER'S DISEASE	activates	gene	0.70
Alzheimer	activates	disease	0.70
NEURODEGENERATION	treats	gene	0.70
Neurodegeneration	treats	disease	0.70
ACOX1	activates	gene	0.60
FASN	activates	gene	0.60
GENES	activates	gene	0.60
AKT	activates	gene	0.60
MTOR	activates	gene	0.60
Carcinoma	activates	disease	0.60
Hepatocellular Carcinoma	activates	disease	0.60
PPAR	contributes_to	gene	0.60
NEURODEGENERATION	contributes_to	gene	0.60
TAU	contributes_to	gene	0.60
PHAGOCYTOSIS	contributes_to	gene	0.60
DEMENTIA	contributes_to	gene	0.60
ALZHEIMER	contributes_to	gene	0.60
CYTOKINES	contributes_to	gene	0.60
AMYLOID	contributes_to	gene	0.60
ASTROCYTES	contributes_to	gene	0.60
ASTROCYTE	contributes_to	gene	0.60
ALZHEIMER'S DISEASE	contributes_to	gene	0.60
AKT	contributes_to	gene	0.60
PPAR-Γ	contributes_to	gene	0.60
MICROGLIA	contributes_to	gene	0.60
NEUROINFLAMMATION	contributes_to	gene	0.60
MTOR	contributes_to	gene	0.60
Tumor	contributes_to	disease	0.60
Als	contributes_to	disease	0.60
Neuroinflammation	contributes_to	disease	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

P38 Mapk

Understanding Entity Pages

Wiki Pages (20)

Alzheimer's Disease Mechanism Index

Therapeutics

NRF2 Oxidative Stress Pathway

IGF-1 Signaling Pathway in Neurodegeneration

Neuroinflammation Across AD, PD, ALS, FTD, and HD

Synaptic Plasticity Deficits in Neurodegeneration

substance-p-nk1-signaling-neurodegeneration

CBS/PSP Genetic Architecture

Neuroinflammation in Parkinson's Disease

CNTFR Gene

AMPA Receptor Neurons

LRP1B — Low Density Lipoprotein Receptor-Related Protein 1B

UBE2V1 Gene (UEV-1)

Tau Pathology

MAPK9 Gene

Oxidative Stress Response in 4R-Tauopathies

vip-vasoactive-intestinal-peptide-signaling-neurodegeneration

MAPK/ERK Signaling Pathway in Neurodegeneration