Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PDGFRA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | PDGFRA |
| Full Name | PDGFRA - Platelet Derived Growth Factor Receptor Alpha |
| Aliases | Page for PDGFRA |
| Chromosome | 4q12 |
| Protein Type | Gene |
| Function | PDGFRA signaling regulates cell proliferation, migration, and survival during development and tissue repair [@uniprot]: |
| Primary Expression | mesenchymal cells including fibroblasts, smooth muscle cells, and glial progenitors [@references] |
| Molecular Weight | 180 kDa |
| Amino Acids | 1086 aa |
| Exons | 23 |
| Pathways | Akt, Differentiation, MAPK signaling, ubiquitin-proteasome |
| NCBI Gene ID | Search NCBI |
| GeneCards | PDGFRA |
| Human Protein Atlas | PDGFRA |
| Associated Diseases | ALS, Cancer, Carcinoma, Glioma, Tumor |
| Interactions | PDGFRB, IL6R, AKT, EPHA2, GBM, PDGFA |
| SciDEX Hypotheses | OPC differentiation blockade contributes to white |
| KG Connections | 105 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
PDGFRA["<b>PDGFRA</b>"]
Ms{"Ms"}
PDGFRA -->|"interacts with"| Ms
Als{"Als"}
PDGFRA -->|"regulates"| Als
Cancer{"Cancer"}
PDGFRA -->|"activates"| Cancer
Tumor{"Tumor"}
PDGFRA -->|"activates"| Tumor
PDGFRA -->|"associated with"| Cancer
Carcinoma{"Carcinoma"}
PDGFRA -->|"associated with"| Carcinoma
PDGFRA -->|"inhibits"| Ms
Glioblastoma{"Glioblastoma"}
PDGFRA -->|"therapeutic target"| Glioblastoma
ALS{"ALS"}
PDGFRA -->|"regulates"| ALS
PDGFRB["PDGFRB"]
PDGFRA -->|"interacts with"| PDGFRB
P53["P53"]
PDGFRA -->|"regulates"| P53
THBS2["THBS2"]
PDGFRA -->|"associated with"| THBS2
GLI1["GLI1"]
GLI1 -->|"regulates"| PDGFRA
PDGFRB -->|"interacts with"| PDGFRA
P53 -->|"regulates"| PDGFRA
GRIK3["GRIK3"]
GRIK3 -->|"inhibits"| PDGFRA
ERK["ERK"]
ERK -->|"inhibits"| PDGFRA
SRC["SRC"]
SRC -->|"activates"| PDGFRA
GRID2["GRID2"]
GRID2 -->|"inhibits"| PDGFRA
THBS2 -->|"regulates"| PDGFRA
NEURON["NEURON"]
NEURON -->|"activates"| PDGFRA
RAS["RAS"]
RAS -->|"inhibits"| PDGFRA
CANCER["CANCER"]
CANCER -->|"activates"| PDGFRA
AND["AND"]
AND -->|"inhibits"| PDGFRA
style PDGFRA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Tumor | activates | disease | 0.75 |
| Ms | interacts_with | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Carcinoma | associated_with | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Glioblastoma | therapeutic_target | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| Glioma | activates | disease | 0.65 |
| Cancer | causes | disease | 0.65 |
| Tumor | causes | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| PDGFRB | interacts_with | gene | 0.60 |
| PI3K | associated_with | gene | 0.60 |
| AKT | associated_with | gene | 0.60 |
| IL6R | activates | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| EPHA2 | inhibits | gene | 0.60 |
| GBM | inhibits | gene | 0.60 |
| PDGFA | inhibits | gene | 0.60 |
| GLI1 | regulates | gene | 0.60 |
| PDGFRB | contributes_to | entity | 0.60 |
| MYC | activates | gene | 0.60 |
| JUN | activates | gene | 0.60 |
| Rb | interacts_with | protein | 0.60 |
| NRG1 | expressed_in | gene | 0.60 |
| Rb | inhibits | protein | 0.60 |
| PDGFRB | implicated_in | gene | 0.60 |
| TP53 | associated_with | gene | 0.60 |
| SETD2 | associated_with | gene | 0.60 |
| PTEN | activates | gene | 0.60 |
| TERT | activates | gene | 0.60 |
| TP53 | activates | gene | 0.60 |
| P53 | regulates | gene | 0.60 |
| THBS2 | associated_with | gene | 0.60 |
| MIRNAS | activates | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| Akt | associated_with | pathway | 0.60 |
| Pi3K | associated_with | pathway | 0.60 |
| Akt | activates | pathway | 0.60 |
| THBS2 | regulates | gene | 0.60 |
| Differentiation | activates | pathway | 0.60 |
| PDGF | interacts_with | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| Stem Cell | regulates | cell_type | 0.60 |
| ONCOGENES | expressed_in | gene | 0.60 |
| AND | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| h_seaad_004 | targets_gene | hypothesis | 0.90 |
| GLI1 | regulates | gene | 0.60 |
| PDGFRB | interacts_with | gene | 0.60 |
| GRIK3 | inhibits | gene | 0.60 |
| SRC | activates | gene | 0.60 |
| GRID2 | inhibits | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| MYC | activates | gene | 0.60 |
| JUN | activates | gene | 0.60 |
| ATRX | associated_with | gene | 0.60 |
| CDKN2A | associated_with | gene | 0.60 |
| EGFR | associated_with | gene | 0.60 |
| NF1 | associated_with | gene | 0.60 |
| AKT3 | activates | gene | 0.60 |
| CDKN2A | activates | gene | 0.60 |
| MDM4 | activates | gene | 0.60 |
| P53 | regulates | gene | 0.60 |
| ERK | inhibits | gene | 0.60 |
| THBS2 | regulates | gene | 0.60 |
| NEURON | activates | gene | 0.60 |
| RAS | inhibits | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| PDGF | interacts_with | gene | 0.60 |
| ONCOGENES | expressed_in | gene | 0.60 |
| MYCN | associated_with | gene | 0.60 |
| MAPK | inhibits | gene | 0.60 |
| PDGFRB | associated_with | gene | 0.50 |
| GLI1 | co_expressed_with | gene | 0.50 |
| P53 | co_expressed_with | protein | 0.50 |
| AGER | associated_with | gene | 0.30 |
| benchmark_ot_ad_answer_key:PDGFRA | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| OPC differentiation blockade contributes to white matter deg | 0.495 | Alzheimer's disease | SEA-AD Single-Cell Analysis: Cell-Type V |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Cancer-Associated Fibroblasts Promote Imatinib Resistance in Gastrointestinal St [PMID:41270149] | Li C, Teng T, Lin X, Sun X, Yi T et al. | Cancer Res | 2026 | 0 |
| A cellular epigenetic classification system for glioblastoma. [PMID:41499453] | Silverbush D, Jürgensen L, Freeburg NF, | Neuro Oncol | 2026 | 0 |
| Gastrointestinal Stromal Tumors: Molecular Mechanisms of Drug Resistance and Adv [PMID:41724491] | Jingnuo D, Huachuan Z, Da Z, Zhi D, Yan | J Gastroenterol Hepatol | 2026 | 0 |
| P16(+) Cells Drive Adverse Postischemic Cardiac Remodeling Through CCL8-Mediated [PMID:41766526] | Yan L, Zheng J, Lu Z, Zhu A, Ye M et al. | Circulation | 2026 | 0 |
| Multi-omics reveals heterogeneity and functional populations of oligodendrocyte [PMID:41771834] | Ye D, Zhou H, Qu S, Wang Z, Zhang F et a | Cell Death Discov | 2026 | 0 |
| Comparison of gene fusion detection algorithms reveals frequently overlooked dri [PMID:41935182] | Tamura Z, Saito Y, Kogure Y, Oshikawa-Ku | NPJ Precis Oncol | 2026 | 0 |
| Single-cell transcriptome analysis indicated that immune-related programmed cell [PMID:41946148] | Sun J, Jing L, Zhu X, Yang H, Sun Y et a | Transl Oncol | 2026 | 0 |
| Lipid emulsion modulates myogenic and collagen-related gene expression in skelet [PMID:41955312] | Li X, Alaniz SM, Louey S, Deavila JM, Jo | Exp Physiol | 2026 | 0 |