concept

SOAT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SOAT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

266Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

SOAT1 is a concept in neurodegeneration research. Key relationships include: activates, interacts with, co discussed. Associated with Als, Alzheimer, Cancer. Connected to 68 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	SOAT1
Key Genes/Proteins	ACAT1
Related Diseases	Cancer

🔮 Predicted Structure: SOAT1 — AlphaFold B1APM4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (20)

Knowledge base pages for this entity

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

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Pathway Diagram

graph TD
    SOAT1["SOAT1"]
    SOAT1 -->|"inhibits"| Zika_Virus_Infection["Zika Virus Infection"]
    SOAT1 -->|"involved_in"| Cholesterol_Ester_Biosynthesis["Cholesterol Ester Biosynthesis"]
    SOAT1 -->|"activates"| Cancer["Cancer"]
    SOAT1 -->|"activates"| Glioblastoma["Glioblastoma"]
    SOAT1 -->|"activates"| Tumor["Tumor"]
    SOAT1 -->|"activates"| Ms["Ms"]
    SOAT1 -->|"inhibits"| DGAT1["DGAT1"]
    h_7d4a24d3["h-7d4a24d3"] -->|"targets"| SOAT1
    GBM["GBM"] -->|"activates"| SOAT1
    DGAT1 -->|"inhibits"| SOAT1
    CD36["CD36"] -->|"activates"| SOAT1
    APOA1["APOA1"] -->|"activates"| SOAT1
    NR1H3["NR1H3"] -->|"activates"| SOAT1
    PLIN2["PLIN2"] -->|"activates"| SOAT1
    SPHK1["SPHK1"] -->|"interacts"| SOAT1
    LPCAT3["LPCAT3"] -->|"interacts"| SOAT1

Outgoing (145)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
ZIKA VIRUS INFECTION	inhibits	entity	0.95
LIPID DROPLET STORAGE	regulates	entity	0.95
CHOLESTERYL ESTER SYNTHESIS	regulates	entity	0.95
CHOLESTEROL ESTER METABOLISM	regulates	entity	0.90
Blastocyst Formation	involved_in	process	0.90
Cell Differentiation	involved_in	process	0.90
lipid droplet storage	upregulates	process	0.90
THERAPEUTIC_TARGET	therapeutic_target	entity	0.90
GLIOBLASTOMA	associated_with	entity	0.90
LIPID METABOLISM	involved_in	entity	0.85
Cancer	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Tumor	activates	disease	0.65
Ms	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Atherosclerosis	transports	disease	0.65
Alzheimer	transports	disease	0.65
ALS	transports	disease	0.65
Atherosclerosis	degrades	disease	0.65
Alzheimer	degrades	disease	0.65
Als	degrades	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Stroke	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
DGAT1	inhibits	gene	0.60
DGAT1	activates	gene	0.60
APOA1	activates	gene	0.60
CD36	activates	gene	0.60
PLIN2	activates	gene	0.60
NR1H3	activates	gene	0.60
SORL1	associated_with	gene	0.60
LRP12	associated_with	gene	0.60
RIPK1	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
GPX4	interacts_with	gene	0.60
DGAT1 AND SOAT1	inhibits	gene	0.60
GBM	activates	gene	0.60
neurodegeneration	implicated_in	disease	0.60
ABCA2	activates	gene	0.60
PSEN2	regulates	gene	0.60
TAU	regulates	gene	0.60

Incoming (121)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
h-7d4a24d3	targets	hypothesis	0.80
ACAT1	inhibits	gene	0.70
DGAT1	co_mentioned_with	gene	0.60
GBM	activates	gene	0.60
DGAT1	inhibits	gene	0.60
DGAT1	activates	gene	0.60
CD36	activates	gene	0.60
APOA1	activates	gene	0.60
NR1H3	activates	gene	0.60
PLIN2	activates	gene	0.60
SPHK1	interacts_with	gene	0.60
DGAT1 AND SOAT1	inhibits	gene	0.60
GPX4	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
DGAT1	expressed_in	entity	0.60
GBM	expressed_in	entity	0.60
APOA1	regulates	entity	0.60
CD36	regulates	entity	0.60
DGAT1	regulates	entity	0.60
NR1H3	regulates	entity	0.60
PLIN2	regulates	entity	0.60
LRP8	activates	gene	0.60
MAPT	regulates	gene	0.60
LRP1	interacts_with	gene	0.60
LIPA	regulates	gene	0.60
APP	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
CYP46A1	activates	gene	0.60
ABCA1	activates	gene	0.60
NCSTN	regulates	gene	0.60
GSK3B	regulates	gene	0.60
PSEN1	regulates	gene	0.60
SREBF1	regulates	gene	0.60
APOC1	activates	gene	0.60
APOC2	activates	gene	0.60
APOE	transports	gene	0.60
NCSTN	transports	gene	0.60
PSEN2	transports	gene	0.60
LIPA	transports	gene	0.60
LDLR	transports	gene	0.60
ABCA1	transports	gene	0.60
GSK3B	transports	gene	0.60
LRP8	transports	gene	0.60
APOA1	transports	gene	0.60
CYP46A1	transports	gene	0.60
SREBF1	degrades	gene	0.60
PSEN1	degrades	gene	0.60
GSK3B	degrades	gene	0.60
NCSTN	degrades	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Astrocyte reactivity subtypes in neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.554

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SOAT1

Understanding Entity Pages

Summary

Wiki Pages (20)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

Sulforaphane and Nrf2 Activation for Neuroprotection

Section 152: Advanced Robotics and Assistive Devices in CBS/PSP

Section 147: Telehealth and Remote Monitoring in CBS/PSP

Section 233: Advanced Virtual Reality and Immersive Technology-Based Rehabilitation in CBS/PSP

O-GlcNAcase (OGA) Inhibitor Landscape — Programs, Mechanisms, Companies

Exosome and Extracellular Vesicle Brain Delivery

Section 156: Pet Therapy and Animal-Assisted Interventions in CBS/PSP

Longevity and Rejuvenation Therapies Landscape

Section 151: Advanced Wearable and Sensor Technologies in CBS/PSP

Section 249: Advanced LSVT Voice and Speech Therapy in CBS/PSP

N-of-1 and Personalized Clinical Trial Design for CBS/PSP

Senolytic Therapies for CBS and [PSP](/diseases/progressive-supranuclear-palsy)

Section 103: Sirtuin Pathway and NAD+-Dependent Deacetylases in CBS/PSP

Section 182: Microbiome Metabolomics and SCFA Therapy in CBS/PSP

Music and Rhythm-Based Therapy for CBS/PSP

Multi-Target Pharmacotherapy and Network Pharmacology for CBS/PSP

Section 240: Advanced Narrative Therapy and Life Review in CBS/PSP