concept

NEP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

121Connections

0Hypotheses

0Analyses

50Outgoing

44Incoming

4Experiments

0Debates

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Wiki Pages (2)

Knowledge base pages for this entity

Neprilysin (NEP / CD10 / MME)

protein · 3068 words

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Neprilysin (NEP)

entity · 1047 words

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Pathway Diagram

graph TD
    NEP["NEP"]
    NEP -->|"catalyzes"| AMYLOID_BETA["AMYLOID BETA"]
    NEP -.protects against.-> Alzheimer_s_Disease["Alzheimer's Disease"]
    NEP -->|"regulates"| amyloid_beta["amyloid-beta"]
    NEP -->|"activates"| Alzheimer["Alzheimer"]
    NEP -->|"expressed in"| ALS["ALS"]
    NEP -->|"expressed in"| Als["Als"]
    NEP -->|"activates"| Neurodegeneration["Neurodegeneration"]
    AHR["AHR"] -->|"upregulates"| NEP
    irisin["irisin"] -->|"activates"| NEP
    NEPRILYSIN["NEPRILYSIN"] -->|"activates"| NEP
    ALZHEIMER["ALZHEIMER"] -->|"activates"| NEP
    APP["APP"] -->|"activates"| NEP
    EXERCISE["EXERCISE"] -->|"inhibits"| NEP

Outgoing (77)

Target	Relation	Type	Str
amyloid-beta	regulates	protein	0.70
Alzheimer	associated_with	disease	0.65
ALS	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Alzheimer	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
Inflammation	contributes_to	disease	0.65
Alzheimer	inhibits	disease	0.65
ALS	regulates	disease	0.65
ALZHEIMER'S DISEASE	inhibits	gene	0.60
ERK	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
Amyloid	inhibits	pathway	0.60
AND	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
STAT3	inhibits	gene	0.60
AND	inhibits	gene	0.60
ASTROCYTES	activates	gene	0.60
Insulin	activates	protein	0.60
IDE	activates	gene	0.60
Apoptosis	activates	pathway	0.60
PARK7	regulates	gene	0.60
PLAT	contributes_to	gene	0.60
ALZHEIMER	regulates	gene	0.60
APP	contributes_to	gene	0.60
CASP4	contributes_to	gene	0.60
GNB5	contributes_to	gene	0.60
SNCA	contributes_to	gene	0.60
ABCA1	contributes_to	gene	0.60
Lipid Metabolism	contributes_to	pathway	0.60
Neurogenesis	contributes_to	pathway	0.60
Oxidative Stress	contributes_to	pathway	0.60
Neuroinflammatory	activates	pathway	0.60
Fibronectin	inhibits	protein	0.60
oxidative stress response	participates_in	pathway	0.60
APOPTOSIS	activates	gene	0.60
endothelial cells	expressed_in	cell_type	0.60
TAU	activates	gene	0.60
ACE2	activates	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
AMYLOID	activates	gene	0.60
Amyloid	activates	pathway	0.60
Alzheimer's disease	protects_against	disease	0.60
PS1	associated_with	gene	0.60
PS1	activates	gene	0.60
Amyloid	associated_with	pathway	0.60
ALZHEIMER	activates	gene	0.60

Incoming (44)

Source	Relation	Type	Str
APP	interacts_with	gene	0.70
irisin	activates	protein	0.70
ALZHEIMER'S DISEASE	activates	gene	0.60
ERK	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
STAT3	inhibits	gene	0.60
APP	associated_with	gene	0.60
IDE	protects_against	gene	0.60
IDE	cleaves	gene	0.60
AHR	activates	gene	0.60
NEPRILYSIN	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
APP	activates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
TAU	activates	gene	0.60
ACE2	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
PLAT	contributes_to	gene	0.60
PARK7	regulates	gene	0.60
ABCA1	contributes_to	gene	0.60
ACE2	associated_with	gene	0.60
IDE	associated_with	gene	0.60
ACE2	expressed_in	gene	0.60
IDE	expressed_in	gene	0.60
NEPRILYSIN	inhibits	gene	0.60
FNDC5	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
PER	inhibits	gene	0.60
NEPRILYSIN	degrades	gene	0.60
GENES	regulates	gene	0.60
INFLAMMATION	contributes_to	gene	0.60
EXERCISE	inhibits	gene	0.60
ALZHEIMER	regulates	gene	0.60
APP	contributes_to	gene	0.60
GNB5	contributes_to	gene	0.60
SNCA	contributes_to	gene	0.60
OXIDATIVE STRESS	contributes_to	gene	0.60
APP/PS1	activates	gene	0.60
CASP4	contributes_to	gene	0.60
PSMB5	contributes_to	gene	0.60
NEURODEGENERATION	activates	gene	0.60
AMYLOID	associated_with	gene	0.60
APOPTOSIS	activates	gene	0.60
IDE	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (4)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
AhR agonist effects on NEP expression in N2a cells	exploratory	Alzheimer's disease	0.900	N2a cells	proposed	N/A
AhR agonist effects on NEP in APP/PS1 mice	validation	Alzheimer's disease	0.900	APP/PS1 mice	proposed	N/A
Diosmin cognitive rescue in APP/PS1 mice	validation	Alzheimer's disease	0.900	APP/PS1 mice	proposed	N/A
AhR transcriptional regulation of NEP gene	exploratory	Alzheimer's disease	0.850	Cell culture system	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity