CHMP2B

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHMP2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

CHMP2B encodes a core ESCRT-III subunit. Mutations cause FTD-3 and ALS through impaired autophagy and endosomal trafficking dysfunction.

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flowchart TD
    CHMP2B["CHMP2B<br/>Charged Multivesicular<br/>Body Protein 2B"]
    
    ESCRT["ESCRT-III<br/>Complex"]
    CHMP2A["CHMP2A<br/>Related Protein"]
    VCP["VCP/Valosin<br/>Containing Protein"]
    
    Autophagy["Autophagy<br/>Dysfunction"]
    Endosome["Endosomal<br/>Trafficking"]
    ProteinAgg["Protein<br/>Aggregation"]
    
    Mutation["CHMP2B<br/>Mutations"]
    LossFunction["Loss of<br/>Function"]
    
    FTD["Frontotemporal<br/>Dementia"]
    ALS["Amyotrophic<br/>Lateral Sclerosis"]
    Dementia["Dementia<br/>Spectrum"]
    
    Neuroinflam["Neuroinflammation"]
    Neurodegeneration["Neurodegeneration"]
    CellDeath["Neuronal<br/>Cell Death"]
    
    Mutation --|"causes"|--> CHMP2B
    CHMP2B --|"forms"|--> ESCRT
    CHMP2B --|"interacts"|--> CHMP2A
    CHMP2B --|"regulates"|--> VCP
    
    ESCRT --|"controls"|--> Endosome
    ESCRT --|"regulates"|--> Autophagy
    
    LossFunction --|"leads to"|--> Autophagy
    Autophagy --|"causes"|--> ProteinAgg
    ProteinAgg --|"triggers"|--> Neuroinflam
    
    CHMP2B --|"mutations activate"|--> FTD
    CHMP2B --|"associated with"|--> ALS
    CHMP2B --|"contributes to"|--> Dementia
    
    Neuroinflam --|"promotes"|--> Neurodegeneration
    Neurodegeneration --|"results in"|--> CellDeath
    
    style CHMP2B fill:#006494
    style ESCRT fill:#4a1a6b
    style CHMP2A fill:#4a1a6b
    style VCP fill:#4a1a6b
    style Autophagy fill:#1b5e20
    style Endosome fill:#1b5e20
    style ProteinAgg fill:#ef5350
    style Mutation fill:#ef5350
    style LossFunction fill:#ef5350
    style FTD fill:#5d4400
    style ALS fill:#5d4400
    style Dementia fill:#5d4400
    style Neuroinflam fill:#ef5350
    style Neurodegeneration fill:#ef5350
    style CellDeath fill:#ef5350