NR4A1

Understanding Entity Pages

This page aggregates everything SciDEX knows about NR4A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

NR4A1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, inhibits. Associated with Als, Alzheimer, Inflammation. Connected to 79 entities in the SciDEX knowledge graph.

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graph TD
    NR4A1["<b>NR4A1</b>"]
    Als{"Als"}
    NR4A1 -->|"activates"| Als
    Ms{"Ms"}
    NR4A1 -->|"activates"| Ms
    NR4A1 -->|"associated with"| Als
    NR4A1 -->|"associated with"| Ms
    Inflammation{"Inflammation"}
    NR4A1 -->|"associated with"| Inflammation
    Autophagy(["Autophagy"])
    NR4A1 -->|"activates"| Autophagy
    Mitophagy(["Mitophagy"])
    NR4A1 -->|"activates"| Mitophagy
    PINK1["PINK1"]
    NR4A1 -->|"associated with"| PINK1
    MAP1LC3["MAP1LC3"]
    NR4A1 -->|"associated with"| MAP1LC3
    TUFM["TUFM"]
    NR4A1 -->|"associated with"| TUFM
    ULK1["ULK1"]
    NR4A1 -->|"associated with"| ULK1
    TRAF2["TRAF2"]
    NR4A1 -->|"associated with"| TRAF2
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"activates"| NR4A1
    P62["P62"]
    P62 -->|"activates"| NR4A1
    SQSTM1["SQSTM1"]
    SQSTM1 -->|"activates"| NR4A1
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"activates"| NR4A1
    BCL2["BCL2"]
    BCL2 -->|"associated with"| NR4A1
    FUNDC1["FUNDC1"]
    FUNDC1 -->|"associated with"| NR4A1
    PARKIN["PARKIN"]
    PARKIN -->|"associated with"| NR4A1
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"associated with"| NR4A1
    TNF["TNF"]
    TNF -->|"associated with"| NR4A1
    FIS1["FIS1"]
    FIS1 -->|"associated with"| NR4A1
    AUTOPHAGY -->|"associated with"| NR4A1
    SNAP29["SNAP29"]
    SNAP29 -->|"associated with"| NR4A1
    style NR4A1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0