concept

PREFRONTAL CORTEX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PREFRONTAL CORTEX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

438Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

5Debates

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💡 Concept Info

Name	PREFRONTAL CORTEX
Key Genes/Proteins	ABCA1, ABCA7, ADAM10, AKT, ALZHEIMER, AMPK
Related Diseases	acetylcholine, ACETYLCHOLINE, aging, AGING, ALS

Pathway Diagram

graph TD
    PREFRONTAL_CORTEX["PREFRONTAL CORTEX"]
    PREFRONTAL_CORTEX -->|"interacts"| Cognition["Cognition"]
    PREFRONTAL_CORTEX -->|"treats"| depression["depression"]
    Cognition -->|"interacts"| PREFRONTAL_CORTEX
    TMS["TMS"] -->|"regulates"| PREFRONTAL_CORTEX
    BDNF["BDNF"] -->|"expressed in"| PREFRONTAL_CORTEX
    PER["PER"] -->|"expressed in"| PREFRONTAL_CORTEX
    CANCER["CANCER"] -->|"expressed in"| PREFRONTAL_CORTEX
    CNO["CNO"] -->|"expressed in"| PREFRONTAL_CORTEX
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"expressed in"| PREFRONTAL_CORTEX
    HSPA1A["HSPA1A"] -->|"expressed in"| PREFRONTAL_CORTEX
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"expressed in"| PREFRONTAL_CORTEX
    MICROGLIA["MICROGLIA"] -->|"expressed in"| PREFRONTAL_CORTEX

Outgoing (102)

Target	Relation	Type	Str
Cognitive Impairment	associated_with	phenotype	0.90
mood regulation	regulates	process	0.85
cortical inhibition	mediates	process	0.85
emotional processing	mediates	process	0.85
Brain Age	involved_in	biomarker	0.80
Executive function	regulates	process	0.70
depression	treats	disease	0.70
Alzheimer's disease	risk_factor_for	disease	0.70
Cognition	activates	entity	0.70
Cognition	associated_with	entity	0.70
vascular-interactive BBB states	associated_with	cell_type	0.70
Cognition	interacts_with	entity	0.70
Cognition	inhibits	entity	0.70
SUBSTANTIA NIGRA	causes	brain_region	0.65
AMYGDALA	regulates	concept	0.50
SEROTONIN	activates	concept	0.50
NUCLEUS	associated_with	concept	0.50
AMYGDALA	associated_with	concept	0.50
GRAY MATTER	interacts_with	concept	0.50
INTERNEURONS	inhibits	concept	0.50
INTERNEURONS	activates	concept	0.50
GRAY MATTER	associated_with	concept	0.50
PURKINJE CELLS	associated_with	cell_type	0.50
NUCLEUS	expressed_in	concept	0.50
Proteins	regulates	protein	0.50
NUCLEUS	inhibits	concept	0.50
NUCLEUS	regulates	concept	0.50
GENE EXPRESSION	inhibits	concept	0.50
TH	associated_with	gene	0.50
FRONTAL	activates	concept	0.50
GENE EXPRESSION	expressed_in	concept	0.50
TET2	associated_with	gene	0.50
NEUROGENESIS	associated_with	phenotype	0.50
GABA	associated_with	phenotype	0.50
AMYLOID-BETA	associated_with	protein	0.45
NEURONS	associated_with	cell_type	0.45
C9orf72	associated_with	gene	0.45
ASTROCYTES	associated_with	cell_type	0.45
AGING	associated_with	phenotype	0.45
APOPTOSIS	associated_with	phenotype	0.45
TAU	associated_with	protein	0.45
TDP-43	associated_with	gene	0.45
SOD1	associated_with	gene	0.45
MEMORY LOSS	associated_with	phenotype	0.45
HMGB1	associated_with	gene	0.45
TLR4	associated_with	gene	0.45
RESVERATROL	associated_with	drug	0.45
METFORMIN	associated_with	drug	0.45
AMPK	associated_with	gene	0.45
BDNF	associated_with	gene	0.45

Incoming (336)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
parvalbumin-positive interneurons	expressed_in	cell_type	0.90
depression	affects	disease	0.90
Psychedelics	modulates	compound	0.90
NECL1	expressed_in	gene	0.85
resistance exercise	associated_with	process	0.85
ASTROCYTES	associated_with	cell_type	0.82
PARKINSON'S DISEASE	associated_with	disease	0.82
NECL1	expressed_in	gene	0.80
NLRP3	expressed_in	protein	0.80
RNA	expressed_in	gene	0.80
Engeletin	targets	compound	0.75
aerobic exercise	modulates	process	0.75
AMYLOID	associated_with	protein	0.74
MICROGLIA	associated_with	cell_type	0.74
BDNF	associated_with	gene	0.74
unfolded protein response	active_in	pathway	0.70
neurodegeneration	affects	disease	0.70
BDNF	expressed_in	protein	0.70
TMS	regulates	process	0.70
APP	regulates	gene	0.70
INFLAMMATION	activates	phenotype	0.70
INFLAMMATION	causes	phenotype	0.70
Cognition	associated_with	entity	0.70
Cognition	interacts_with	entity	0.70
AMPA receptor	expressed_in	receptor	0.70
anxiety	affects	disease	0.70
serotonin	active_in	neurotransmitter	0.70
dopamine receptor	expressed_in	receptor	0.70
APOPTOSIS	regulates	phenotype	0.65
DEPRESSION	regulates	disease	0.65
NEURONS	causes	cell_type	0.65
FERROPTOSIS	causes	phenotype	0.65
DRD2	mediates	gene	0.65
CORTEX	mediates	brain_region	0.65
NEURON	contributes_to	cell_type	0.65
DOPAMINERGIC	causes	cell_type	0.65
CORTEX	causes	brain_region	0.65
BDNF	phosphorylates	gene	0.65
CORTEX	contributes_to	brain_region	0.65
CORTEX	impairs	brain_region	0.65
HIPPOCAMPUS	contributes_to	brain_region	0.65
CORTEX	targets	brain_region	0.65
CORTEX	biomarker_for	brain_region	0.65
CORTEX	transports	brain_region	0.65
C9ORF72	regulates	gene	0.65
TAU	associated_with	protein	0.64
neuropeptide Y	active_in	neurotransmitter	0.60
glutamate receptor	expressed_in	receptor	0.60
endocannabinoids	active_in	neurotransmitter	0.60