Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MYELINATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
MYELINATION is a concept in neurodegeneration research. Key relationships include: co discussed, impairs, expressed in. Associated with ALZHEIMER, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 57 entities in the SciDEX knowledge graph.
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Knowledge base pages for this entity
graph TD
MYELINATION["MYELINATION"]
HDAC7["HDAC7"] -->|"regulates"| MYELINATION
AQP4["AQP4"] -->|"activates"| MYELINATION
CD19["CD19"] -->|"target for"| MYELINATION
GPR37["GPR37"] -->|"inhibits"| MYELINATION
CR2["CR2"] -->|"inhibits"| MYELINATION
OVERVIEW["OVERVIEW"] -->|"inhibits"| MYELINATION
SOD1["SOD1"] -->|"regulates"| MYELINATION
GFAP["GFAP"] -->|"activates"| MYELINATION
COMPLEMENT["COMPLEMENT"] -->|"causes"| MYELINATION| Target | Relation | Type | Str |
|---|---|---|---|
| RNA | regulates | gene | 0.60 |
| SREBF2 | regulates | gene | 0.60 |
| OLIGODENDROCYTE | co_discussed | entity | 0.50 |
| OLIGODENDROCYTES | co_discussed | entity | 0.50 |
| STING | co_discussed | entity | 0.50 |
| AXON | activates | concept | 0.50 |
| VESICLE TRAFFICKING | activates | concept | 0.50 |
| Epilepsy | associated_with | disease | 0.50 |
| WHITE MATTER | co_discussed | entity | 0.50 |
| OXIDATIVE STRESS | co_discussed | entity | 0.50 |
| TREM2 | co_discussed | entity | 0.50 |
| SYNAPTIC PLASTICITY | co_discussed | entity | 0.50 |
| UNFOLDED PROTEIN RESPONSE | co_discussed | entity | 0.50 |
| P2RY12 | co_discussed | entity | 0.50 |
| NEURON | co_discussed | entity | 0.50 |
| MYELIN | inhibits | concept | 0.50 |
| MYELIN | associated_with | concept | 0.50 |
| REMYELINATION | associated_with | concept | 0.50 |
| MYELIN | interacts_with | concept | 0.50 |
| MYELIN | regulates | concept | 0.50 |
| disease | expressed_in | disease | 0.50 |
| NEURONS | expressed_in | concept | 0.50 |
| PARKINSON'S | expressed_in | concept | 0.50 |
| OLIGODENDROCYTES | expressed_in | concept | 0.50 |
| DEMYELINATION | expressed_in | concept | 0.50 |
| OLIGODENDROCYTES | associated_with | concept | 0.50 |
| CENTRAL NERVOUS SYSTEM | associated_with | concept | 0.50 |
| CELL PROLIFERATION | regulates | concept | 0.50 |
| Cognitive Impairment | inhibits | phenotype | 0.50 |
| T Cell | associated_with | cell_type | 0.50 |
| PHAGOCYTOSIS | co_discussed | entity | 0.50 |
| TBI | co_discussed | entity | 0.50 |
| SPINAL CORD | co_discussed | entity | 0.50 |
| TDP-43 | co_discussed | entity | 0.50 |
| PYROPTOSIS | co_discussed | entity | 0.50 |
| TLR4 | co_discussed | entity | 0.50 |
| STAT3 | co_discussed | entity | 0.50 |
| NEURODEGENERATION | co_discussed | entity | 0.50 |
| OPTN | co_discussed | entity | 0.50 |
| RIPK1 | co_discussed | entity | 0.50 |
| RIPK3 | co_discussed | entity | 0.50 |
| MYELIN | activates | concept | 0.50 |
| White Matter | activates | process | 0.50 |
| REMYELINATION | activates | concept | 0.50 |
| Microglia | associated_with | cell_type | 0.50 |
| Macrophage | associated_with | cell_type | 0.50 |
| NEUROINFLAMMATION | co_discussed | entity | 0.50 |
| NLRP3 | co_discussed | entity | 0.50 |
| SPHINGOLIPID | co_discussed | entity | 0.50 |
| TAU | co_discussed | entity | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Iron | involved_in | compound | 0.95 |
| OCN | inhibits | protein | 0.95 |
| APOE4 | associated_with | gene | 0.95 |
| Cholesterol Dysregulation | inhibits | mechanism | 0.90 |
| APOE4 | impairs | gene | 0.90 |
| Microglia Activation | regulates | process | 0.85 |
| GBA1 | regulates | gene | 0.80 |
| HDAC7 | regulates | protein | 0.80 |
| Microglia | regulates | cell_type | 0.80 |
| Metabolic Reprogramming | enhances | mechanism | 0.70 |
| SYNAPSE | activates | gene | 0.60 |
| BUBR1 | regulates | gene | 0.60 |
| ASTROCYTES | associated_with | gene | 0.60 |
| IMMUNE INFILTRATION | associated_with | gene | 0.60 |
| NEUROTOXICITY | contributes_to | gene | 0.60 |
| OXIDATIVE STRESS | contributes_to | gene | 0.60 |
| ALZHEIMER | protects_against | gene | 0.60 |
| NEUROTOXICITY | protects_against | gene | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | inhibits | gene | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| GABRA1 | associated_with | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 0.60 |
| OLIGODENDROCYTE | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| AQP4 | activates | gene | 0.60 |
| CR2 | inhibits | gene | 0.60 |
| ST3GAL5 | contributes_to | gene | 0.60 |
| ALZHEIMER'S DISEASE | protects_against | gene | 0.60 |
| NEURODEGENERATION | protects_against | gene | 0.60 |
| OVERVIEW | inhibits | gene | 0.60 |
| CD19 | therapeutic_target | gene | 0.60 |
| INFLAMMATION | inhibits | gene | 0.60 |
| DEPRESSION | interacts_with | gene | 0.60 |
| GUT-BRAIN AXIS | inhibits | gene | 0.60 |
| DISEASE-ASSOCIATED MICROGLIA | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| JUN | associated_with | gene | 0.60 |
| MICROGLIA | associated_with | gene | 0.60 |
| GABRG2 | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | contributes_to | gene | 0.60 |
| ASTROCYTE | associated_with | gene | 0.60 |
| AMYOTROPHIC LATERAL SCLEROSIS | contributes_to | gene | 0.60 |
| SOD1 | contributes_to | gene | 0.60 |
| PARKINSON | contributes_to | gene | 0.60 |
| NEURODEGENERATIVE DISORDERS | contributes_to | gene | 0.60 |
| APOPTOSIS | contributes_to | gene | 0.60 |
| AMYLOID | contributes_to | gene | 0.60 |
| NEURON | contributes_to | gene | 0.60 |
| ALZHEIMER | contributes_to | gene | 0.60 |
| ALS | contributes_to | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity