USP7

Understanding Entity Pages

This page aggregates everything SciDEX knows about USP7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

USP7 is a gene implicated in neurodegeneration research. Key relationships include: regulates, inhibits, activates. Associated with ALS, Als, Cancer. Connected to 76 entities in the SciDEX knowledge graph.

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graph TD
    USP7["<b>USP7</b>"]
    UBA52["UBA52"]
    USP7 -->|"modifies"| UBA52
    AMBRA1["AMBRA1"]
    USP7 -->|"modifies"| AMBRA1
    UBIQUITINATION(["UBIQUITINATION"])
    USP7 -->|"regulates"| UBIQUITINATION
    Cancer{"Cancer"}
    USP7 -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    USP7 -->|"inhibits"| Tumor
    Als{"Als"}
    USP7 -->|"associated with"| Als
    Ms{"Ms"}
    USP7 -->|"therapeutic target"| Ms
    USP7 -->|"therapeutic target"| Als
    USP7 -->|"activates"| Tumor
    USP7 -->|"expressed in"| Ms
    USP7 -->|"activates"| Cancer
    Inflammation{"Inflammation"}
    USP7 -->|"regulates"| Inflammation
    MLKL["MLKL"]
    MLKL -->|"regulates"| USP7
    H2O2["H2O2"]
    H2O2 -->|"activates"| USP7
    HNRNPA1["HNRNPA1"]
    HNRNPA1 -->|"inhibits"| USP7
    GENES["GENES"]
    GENES -->|"inhibits"| USP7
    MIRNAS["MIRNAS"]
    MIRNAS -->|"inhibits"| USP7
    ALOX15["ALOX15"]
    ALOX15 -->|"inhibits"| USP7
    MIRNAS -->|"activates"| USP7
    CANCER["CANCER"]
    CANCER -->|"activates"| USP7
    LC3B["LC3B"]
    LC3B -->|"expressed in"| USP7
    YY1["YY1"]
    YY1 -->|"interacts with"| USP7
    ROS["ROS"]
    ROS -->|"inhibits"| USP7
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"inhibits"| USP7
    style USP7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0