Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about anxa1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ANXA1 |
| Full Name | Annexin A1 |
| Chromosome | 9q21.13 |
| Target Class | Signaling Protein |
| Function | ANXA1 performs diverse cellular functions: |
| Mechanism of Action | Calcium-dependent phospholipid binding protein modulator |
| Primary Expression | the nervous system: |
| Druggability | Low (0.41) |
| Clinical Stage | Approved |
| Molecular Weight | ~37 kDa |
| Amino Acids | 346 aa |
| Exons | 13 |
| Pathways | Apoptosis, Blood-Brain Barrier, Immune Response, Mtor, cGAS/STING Pathway |
| UniProt ID | P04083 |
| NCBI Gene ID | 303 |
| Ensembl ID | ENSG00000109255 |
| OMIM | 151690 |
| GeneCards | ANXA1 |
| Human Protein Atlas | ANXA1 |
| Associated Diseases | ALS, ALZHEIMER, Aging, Cancer, Depression |
| Known Drugs/Compounds | Tat-NTS, Tat-Nts, aducanumab, Tat-NTS peptide, GW201 |
| Interactions | NBR1, CGAS, STING, TNF, CX3CR1, Sumo |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Synaptic Phosphatidylserine Masking via Annexin A1 |
| KG Connections | 530 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
ANXA1["ANXA1"]
ANXA1 -.biomarker for.-> bladder_cancer["bladder cancer"]
ANXA1 -->|"component_of"| ARPS["ARPS"]
ANXA1 -.protects against.-> Ischemia["Ischemia"]
ANXA1 -->|"target for"| Aging["Aging"]
ANXA1 -->|"target for"| Stroke["Stroke"]
ANXA1 -->|"activates"| Als["Als"]
ANXA1 -->|"regulates"| Inflammation["Inflammation"]
ANXA1 -->|"regulates"| Neuroinflammation["Neuroinflammation"]
h_513a633f["h-513a633f"] -->|"target for"| ANXA1
JUN["JUN"] -->|"target for"| ANXA1
TNF["TNF"] -->|"target for"| ANXA1
NBR1["NBR1"] -->|"activates"| ANXA1
CX3CR1["CX3CR1"] -->|"target for"| ANXA1
NTS["NTS"] -.protects against.-> ANXA1
AMPK["AMPK"] -->|"regulates"| ANXA1
MTOR["MTOR"] -->|"regulates"| ANXA1
CD68["CD68"] -->|"expressed in"| ANXA1| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | implicated_in | disease | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Tat-Nts | targets | drug | 0.95 |
| MIR374B | downregulates | gene | 0.95 |
| Cd68+ Macrophages | expressed_in | cell_type | 0.92 |
| Tat-NTS | targets | drug | 0.90 |
| Tat-NTS peptide | binds | drug | 0.90 |
| LINC00491 | upregulates | gene | 0.90 |
| warm ischemic time | downregulates | process | 0.90 |
| h-513a633f | targets_gene | hypothesis | 0.90 |
| FPR2 | binds | receptor | 0.85 |
| ALX | binds | receptor | 0.85 |
| PURA | inhibits | protein | 0.85 |
| Purα | inhibits | protein | 0.85 |
| GW201 | modulates | compound | 0.85 |
| h-513a633f | targets | hypothesis | 0.80 |
| cGAS/STING Pathway | activates | pathway | 0.80 |
| TAT-NTS | promotes_SUMOylation_of | compound | 0.80 |
| MICROGLIA | SUMOylates | cell_type | 0.80 |
| GW201 | upregulates | compound | 0.75 |
| CASP3 | associated_with | gene | 0.60 |
| JUN | therapeutic_target | gene | 0.60 |
| TNF | therapeutic_target | gene | 0.60 |
| NBR1 | activates | gene | 0.60 |
| CX3CR1 | therapeutic_target | gene | 0.60 |
| NTS | protects_against | gene | 0.60 |
| MTOR | regulates | gene | 0.60 |
| CD68 | expressed_in | gene | 0.60 |
| CGAS | inhibits | gene | 0.60 |
| STING | activates | gene | 0.60 |
| ANXA2 | contributes_to | gene | 0.60 |
| OVERVIEW | regulates | gene | 0.60 |
| LMNA | associated_with | gene | 0.60 |
| CX3CR1 | activates | gene | 0.60 |
| JUN | contributes_to | gene | 0.60 |
| JUN | implicated_in | gene | 0.60 |
| TNF | activates | gene | 0.60 |
| OVERVIEW | biomarker_for | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| AKT | expressed_in | gene | 0.60 |
| AKT | regulates | gene | 0.60 |
| AMPK | regulates | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| NF-ΚB | activates | gene | 0.60 |
| STROKE | associated_with | gene | 0.60 |
| NEURON | protects_against | gene | 0.60 |
| TNF-Α | activates | gene | 0.60 |
| MICROGLIA | activates | gene | 0.60 |
| BRAIN INJURY | contributes_to | gene | 0.60 |
| APOPTOSIS | regulates | gene | 0.60 |
| STROKE | regulates | gene | 0.60 |
| INFLAMMATION | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||