Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about UBIQUITIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
UBIQUITIN is a protein involved in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with ALS, AMYOTROPHIC LATERAL SCLEROSIS, Aging. Connected to 2278 entities in the SciDEX knowledge graph.
| Gene Symbol | UBIQUITIN |
| Function | is a highly conserved 76-amino acid protein that covalently attaches to target proteins to mark them for various cellular fates. |
| Pathways | Adaptive Immunity, Akt, Angiogenesis, Apoptosis, Autophagy |
| GeneCards | UBIQUITIN |
| Human Protein Atlas | UBIQUITIN |
| Linkage | Function |
| K48 | Proteasomal degradation |
| K63 | Endocytosis, signaling, autophagy |
| K11 | Cell cycle regulation |
| K27 | DNA damage response |
| K33 | Mitochondrial quality control |
| K29 | Lysosomal degradation |
| K6 | Mitochondrial dynamics |
| M1 (linear) | NF-κB signaling |
| Associated Diseases | ALS, Aging, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis |
| Known Drugs/Compounds | proteolysis-targeting chimeras, RAPAMYCIN |
| Interactions | DDB1, ATG12, ATG16L1, ATG5, P62, KEAP1 |
| KG Connections | 4017 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
subgraph Signaling["Signaling"]
UBIQUITIN["UBIQUITIN"] -->|"regulates"| Als["Als"]
UBIQUITIN["UBIQUITIN"] -->|"regulates"| Apoptosis["Apoptosis"]
UBIQUITIN["UBIQUITIN"] -->|"regulates"| Autophagy_1["Autophagy"]
UBIQUITIN["UBIQUITIN"] -->|"activates"| Oxidative_Stress["Oxidative Stress"]
UBIQUITIN["UBIQUITIN"] -->|"regulates"| Proteasome["Proteasome"]
UBIQUITIN["UBIQUITIN"] -->|"regulates"| Ubiquitin_Proteasome["Ubiquitin-Proteasome"]
UBIQUITIN["UBIQUITIN"] -->|"activates"| Als_2["Als"]
UBIQUITIN["UBIQUITIN"] -->|"activates"| Cancer["Cancer"]
OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"activates"| UBIQUITIN["UBIQUITIN"]
TLR4["TLR4"] -->|"activates"| UBIQUITIN["UBIQUITIN"]
NEURODEGENERATION["NEURODEGENERATION"] -->|"regulates"| UBIQUITIN["UBIQUITIN"]
end
subgraph Interactions["Interactions"]
UBIQUITIN["UBIQUITIN"] -->|"interacts with"| Autophagy["Autophagy"]
end
subgraph Pathology["Pathology"]
AUTOPHAGY["AUTOPHAGY"] -->|"associated with"| UBIQUITIN["UBIQUITIN"]
end
subgraph Therapeutic["Therapeutic"]
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"therapeutic target"| UBIQUITIN["UBIQUITIN"]
NEURODEGENERATION_3["NEURODEGENERATION"] -->|"therapeutic target"| UBIQUITIN["UBIQUITIN"]
end
style UBIQUITIN fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style Als fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Apoptosis fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Autophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Autophagy_1 fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Oxidative_Stress fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Proteasome fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Ubiquitin_Proteasome fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Als_2 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Cancer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style OXIDATIVE_STRESS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style TLR4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style AUTOPHAGY fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PARKINSON_S_DISEASE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style NEURODEGENERATION fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style NEURODEGENERATION_3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| PARKIN | associated_with | gene | 1.00 |
| PARKIN | activates | gene | 1.00 |
| PARKIN | regulates | gene | 1.00 |
| Als | regulates | disease | 1.00 |
| Apoptosis | regulates | pathway | 1.00 |
| Autophagy | interacts_with | pathway | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Proteasome | regulates | pathway | 1.00 |
| Ubiquitin-Proteasome | regulates | pathway | 1.00 |
| Als | activates | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| Als | interacts_with | disease | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Cancer | regulates | disease | 1.00 |
| CANCER | regulates | gene | 1.00 |
| Tumor | regulates | disease | 1.00 |
| Autophagy | associated_with | pathway | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| Mitophagy | activates | pathway | 1.00 |
| Parkinson | activates | disease | 1.00 |
| Aging | associated_with | disease | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| Parkinson | therapeutic_target | disease | 1.00 |
| Parkinson | regulates | disease | 1.00 |
| Neurodegeneration | regulates | disease | 1.00 |
| Immune Response | regulates | pathway | 1.00 |
| Neurodegeneration | therapeutic_target | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Proteasome | associated_with | pathway | 1.00 |
| Ubiquitin-Proteasome | associated_with | pathway | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| Proteasome | inhibits | pathway | 1.00 |
| Proteasome | activates | pathway | 1.00 |
| Ubiquitin-Proteasome | activates | pathway | 1.00 |
| Carcinoma | activates | disease | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Aging | activates | disease | 1.00 |
| Inflammasome | activates | pathway | 1.00 |
| Mitophagy | regulates | pathway | 1.00 |
| Ubiquitin-Proteasome | therapeutic_target | pathway | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TLR4 | activates | gene | 1.00 |
| NLRP3 | activates | gene | 1.00 |
| KEAP1 | interacts_with | gene | 1.00 |
| PINK1 | regulates | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| PARKINSON'S DISEASE | therapeutic_target | gene | 1.00 |
| NEURODEGENERATION | regulates | gene | 1.00 |
| NEURODEGENERATION | therapeutic_target | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| PARKINSON'S DISEASE | associated_with | gene | 1.00 |
| MITOPHAGY | associated_with | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| NF-ΚB | activates | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| LYSOSOME | activates | gene | 1.00 |
| PARKINSON | associated_with | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| PARKINSON | activates | gene | 1.00 |
| NEURODEGENERATION | implicated_in | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| ALZHEIMER | associated_with | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| PINK1 | inhibits | gene | 1.00 |
| P62 | regulates | gene | 1.00 |
| MITOPHAGY | inhibits | gene | 1.00 |
| OXIDATIVE STRESS | regulates | gene | 1.00 |
| APOPTOSIS | regulates | gene | 1.00 |
| LYSOSOME | regulates | gene | 1.00 |
| GENES | regulates | gene | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| PARKINSON'S DISEASE | implicated_in | gene | 1.00 |
| AUTOPHAGY | therapeutic_target | gene | 1.00 |
| PARKINSON | therapeutic_target | gene | 1.00 |
| P62 | associated_with | gene | 0.98 |
| PINK1 | activates | gene | 0.98 |
| TAU | associated_with | gene | 0.98 |
| AUTOPHAGY | regulates | gene | 0.98 |
| DUB | cleaves | enzyme | 0.95 |
| OPTN | binds_to | entity | 0.95 |
| E1, E2, E3 enzymes | modulates | protein | 0.95 |
| USP9X | associated_with | gene | 0.95 |
| E3 Ubiquitin Ligases | mediates | enzyme | 0.95 |
| USP10 | removes | protein | 0.95 |
| FBXL7 | mediates | protein | 0.95 |
| ABLIM1 | interacts_with | protein | 0.92 |
| ANLN | modified_by | protein | 0.92 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-08 | 0 hypotheses
neurodegeneration | 2026-04-07 | 0 hypotheses
neurodegeneration | 2026-04-06 | 0 hypotheses
neurodegeneration | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||