concept

ZO1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ZO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

182Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

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Wiki Pages (1)

Knowledge base pages for this entity

PIEZO1 — Piezo Type Mechanosensitive Ion Channel Component 1

gene · 1444 words

→

Pathway Diagram

graph TD
    ZO1["ZO1"]
    style ZO1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    ZO1 -->|"expressed in"| Als["Als"]
    ZO1 -->|"activates"| CLDN5([CLDN5])
    ZO1 -->|"expressed in"| IL8([IL8])
    ZO1 -->|"expressed in"| Innate_Immunity["Innate Immunity"]
    ZO1 -->|"activates"| Toll_Like_Receptor["Toll-Like Receptor"]
    ZO1 -->|"expressed in"| Immune_Response["Immune Response"]
    ZO1 -->|"implicated in"| neurodegeneration["neurodegeneration"]
    ZO1 -->|"involved_in"| Blood_brain_barrier["Blood-brain barrier"]
    ZO1 -.->|"biomarker for"| Corneal_epithelium["Corneal epithelium"]
    Byf{"Byf"} -->|"upregulates"| ZO1
    Nobiletin["Nobiletin"] -->|"upregulates"| ZO1
    h_6c83282d["h-6c83282d"] -->|"targets"| ZO1
    PPARG([PPARG]) -->|"upregulates"| ZO1
    CMVS([CMVS]) -->|"activates"| ZO1
    BYF{"BYF"} -->|"activates"| ZO1
    GAL([GAL]) -->|"activates"| ZO1
    CYTOKINES([CYTOKINES]) -->|"activates"| ZO1
    TLR2([TLR2]) -->|"activates"| ZO1
    OCLN([OCLN]) -->|"activates"| ZO1

Outgoing (109)

Target	Relation	Type	Str
Blood-Brain Barrier	biomarker_for	brain_region	0.85
ALS	activates	disease	0.65
Stroke	activates	disease	0.65
Diabetes	activates	disease	0.65
Als	activates	disease	0.65
Als	expressed_in	disease	0.65
TNF	activates	gene	0.60
ACTB	regulates	gene	0.60
IL8	expressed_in	gene	0.60
endothelial cells	expressed_in	cell_type	0.60
UBC	regulates	gene	0.60
Innate Immunity	expressed_in	pathway	0.60
Toll-Like Receptor	activates	pathway	0.60
Immune Response	expressed_in	pathway	0.60
Il-1	activates	protein	0.60
Ras	activates	protein	0.60
App	activates	protein	0.60
Mapk	activates	pathway	0.60
IL-1	activates	gene	0.60
Epithelial	expressed_in	cell_type	0.60
Endothelial	expressed_in	cell_type	0.60
neurodegeneration	implicated_in	disease	0.60
ALZHEIMER	expression	disease	0.60
CLDN5, OCLN	activates	gene	0.60
JNK	activates	gene	0.60
SDHA	regulates	gene	0.60
ERK	activates	gene	0.60
STROKE	activates	gene	0.60
OCLN	activates	gene	0.60
CLDN5	activates	gene	0.60
Blood-brain barrier	involved_in	pathway	0.60
Corneal epithelium	biomarker_for	tissue	0.60
blood-brain barrier	participates_in	pathway	0.55
Cortex	expressed_in	brain_region	0.55
neurodegeneration	associated_with	disease	0.53
CLDN1	interacts_with	gene	0.53
OCLN	interacts_with	gene	0.53
MLCK	interacts_with	gene	0.53
Gut-brain axis / microbiome signaling	participates_in	pathway	0.46
AHR	co_discussed	gene	0.40
NLRP3	co_discussed	gene	0.40
DNMT1	co_discussed	gene	0.40
CASP1	co_discussed	gene	0.40
AADC	co_discussed	gene	0.40
IL1B	co_discussed	gene	0.40
TLR4	co_discussed	gene	0.40
TGFB1	co_discussed	gene	0.40
PYCARD	co_discussed	gene	0.40
IL10	co_discussed	gene	0.40
MLCK	co_discussed	gene	0.40

Incoming (73)

Source	Relation	Type	Str
Betulinic Acid	upregulates	compound	0.95
Byf	upregulates	drug	0.95
h-6c83282d	targets_gene	hypothesis	0.90
Nobiletin	upregulates	compound	0.85
PPARG	upregulates	gene	0.80
Endoplasmic Reticulum Stress	downregulates	process	0.80
h-6c83282d	targets	hypothesis	0.80
CMVS	activates	protein	0.72
BYF	activates	drug	0.64
OCLN	activates	gene	0.60
CLDN5	activates	gene	0.60
AND	expressed_in	gene	0.60
AND	activates	gene	0.60
MAPK	activates	gene	0.60
GENES	regulates	gene	0.60
CYTOKINES	activates	gene	0.60
GAL	activates	gene	0.60
TLR2	activates	gene	0.60
CLDN5	co_expressed_with	protein	0.60
OCLN	co_expressed_with	protein	0.60
KLF11	regulates	protein	0.60
ERK	activates	gene	0.60
IL-1	activates	gene	0.60
STROKE	activates	gene	0.60
BMSC-EVs	protects_against	cell_type	0.60
BEC-EVs	protects_against	cell_type	0.60
CAVEOLIN-1	regulates	protein	0.60
AMPK	activates	pathway	0.60
CLDN5	expressed_in	gene	0.60
OCLN	expressed_in	gene	0.60
UBC	regulates	gene	0.60
ACTB	regulates	gene	0.60
GAPDH	regulates	gene	0.60
JNK	activates	gene	0.60
TNF	activates	gene	0.60
SDHA	regulates	gene	0.60
CLDN5	binds_to	gene	0.60
OCLN	binds_to	gene	0.60
CLDN1	expressed_in	gene	0.55
CLDN1	regulates	gene	0.55
OCLN	regulates	gene	0.55
CLDN1	activates	gene	0.55
CLDN1	co_mentioned	gene	0.55
CLDN1	interacts_with	gene	0.53
OCLN	interacts_with	gene	0.53
MLCK	interacts_with	gene	0.53
SIRT1	co_discussed	entity	0.50
MMP2	co_discussed	entity	0.50
MMP9	co_discussed	entity	0.50
STROKE	co_discussed	entity	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 20 hypotheses Top: 0.865

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What are the mechanisms underlying what are the mechanisms by which gut microbio

closed · Rounds: 4 · Score: 0.95 · 2026-04-01