Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TFCP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | TFCP2 |
| Related Diseases | Alzheimer, Tumor, ALS, Als, Atherosclerosis |
graph TD
TFCP2["TFCP2"]
style TFCP2 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
TFCP2 -->|"regulates"| Alzheimer_s_Disease_Susceptibi["Alzheimer's Disease Susceptibility Genes"]
TFCP2 -->|"regulates"| Alzheimer["Alzheimer"]
TFCP2 -->|"interacts"| Tumor["Tumor"]
TFCP2 -->|"interacts"| ALS["ALS"]
TFCP2 -->|"interacts"| Als["Als"]
TFCP2 -->|"regulates"| Atherosclerosis["Atherosclerosis"]
Hsv_1["Hsv-1"] -->|"binds"| TFCP2
IL6([IL6]) -->|"interacts"| TFCP2
APOE([APOE]) -->|"interacts"| TFCP2
NCSTN([NCSTN]) -->|"interacts"| TFCP2
PSEN2([PSEN2]) -->|"interacts"| TFCP2
IL1B([IL1B]) -->|"interacts"| TFCP2
DAPK1([DAPK1]) -->|"interacts"| TFCP2
APH1B([APH1B]) -->|"interacts"| TFCP2
FAS([FAS]) -->|"interacts"| TFCP2
MAPT([MAPT]) -->|"interacts"| TFCP2| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's Disease Susceptibility Genes | regulates | process | 0.80 |
| Alzheimer | regulates | disease | 0.65 |
| Tumor | interacts_with | disease | 0.65 |
| ALS | interacts_with | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Atherosclerosis | regulates | disease | 0.65 |
| Atherosclerosis | transports | disease | 0.65 |
| Alzheimer | transports | disease | 0.65 |
| ALS | transports | disease | 0.65 |
| Alzheimer | encodes | disease | 0.65 |
| Atherosclerosis | degrades | disease | 0.65 |
| Alzheimer | degrades | disease | 0.65 |
| Als | degrades | disease | 0.65 |
| AMYLOID | interacts_with | gene | 0.60 |
| HSPG2 | interacts_with | gene | 0.60 |
| DYNEIN | interacts_with | gene | 0.60 |
| MITOCHONDRIAL DNA | interacts_with | gene | 0.60 |
| HMGCR | interacts_with | gene | 0.60 |
| TNF | interacts_with | gene | 0.60 |
| APP | interacts_with | gene | 0.60 |
| MAPT | interacts_with | gene | 0.60 |
| APH1B | interacts_with | gene | 0.60 |
| FAS | interacts_with | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.60 |
| DAPK1 | interacts_with | gene | 0.60 |
| PSEN1 | interacts_with | gene | 0.60 |
| APOPTOSIS | interacts_with | gene | 0.60 |
| PEN2 | interacts_with | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| DNA | interacts_with | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| EIF2AK2 | interacts_with | gene | 0.60 |
| SREBF1 | interacts_with | gene | 0.60 |
| PARP1 | interacts_with | gene | 0.60 |
| DHCR24 | interacts_with | gene | 0.60 |
| A2M | interacts_with | gene | 0.60 |
| LMNA | interacts_with | gene | 0.60 |
| Apoptosis | interacts_with | pathway | 0.60 |
| Amyloid | interacts_with | pathway | 0.60 |
| PSEN2 | interacts_with | gene | 0.60 |
| IL6 | interacts_with | gene | 0.60 |
| Cholesterol | interacts_with | pathway | 0.60 |
| IL10 | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| PLAU | associated_with | gene | 0.60 |
| BDNF | associated_with | gene | 0.60 |
| PSEN1 | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Hsv-1 | binds | entity | 0.85 |
| HSV-1 | binds | entity | 0.80 |
| IL6 | interacts_with | gene | 0.60 |
| APOE | interacts_with | gene | 0.60 |
| NCSTN | interacts_with | gene | 0.60 |
| PSEN2 | interacts_with | gene | 0.60 |
| IL1B | interacts_with | gene | 0.60 |
| DAPK1 | interacts_with | gene | 0.60 |
| APH1B | interacts_with | gene | 0.60 |
| FAS | interacts_with | gene | 0.60 |
| MAPT | interacts_with | gene | 0.60 |
| PARP1 | interacts_with | gene | 0.60 |
| A2M | interacts_with | gene | 0.60 |
| APOPTOSIS | interacts_with | gene | 0.60 |
| DHCR24 | interacts_with | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| APP | interacts_with | gene | 0.60 |
| HMGCR | interacts_with | gene | 0.60 |
| DYNEIN | interacts_with | gene | 0.60 |
| EIF2AK2 | interacts_with | gene | 0.60 |
| PEN2 | interacts_with | gene | 0.60 |
| LMNA | interacts_with | gene | 0.60 |
| TNF | interacts_with | gene | 0.60 |
| PSEN1 | interacts_with | gene | 0.60 |
| SREBF1 | interacts_with | gene | 0.60 |
| HSPG2 | interacts_with | gene | 0.60 |
| SORL1 | associated_with | gene | 0.60 |
| IL1A | associated_with | gene | 0.60 |
| CH25H | regulates | gene | 0.60 |
| LRP8 | regulates | gene | 0.60 |
| APOA1 | regulates | gene | 0.60 |
| MAPT | regulates | gene | 0.60 |
| LRP1 | regulates | gene | 0.60 |
| LIPA | regulates | gene | 0.60 |
| APP | regulates | gene | 0.60 |
| APOE | regulates | gene | 0.60 |
| CYP46A1 | regulates | gene | 0.60 |
| ABCA1 | regulates | gene | 0.60 |
| NCSTN | regulates | gene | 0.60 |
| APOD | regulates | gene | 0.60 |
| GSK3B | regulates | gene | 0.60 |
| PSEN1 | regulates | gene | 0.60 |
| SREBF1 | regulates | gene | 0.60 |
| APOC1 | regulates | gene | 0.60 |
| IL6 | associated_with | gene | 0.60 |
| TGFB1 | associated_with | gene | 0.60 |
| APOE | transports | gene | 0.60 |
| PSEN2 | regulates | gene | 0.60 |
| LIPA | transports | gene | 0.60 |
| LDLR | transports | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||