Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HUWE1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | HUWE1 |
| Full Name | HECT, UBA and WWE Domain Containing E3 Ubiquitin Protein Ligase 1 |
| Aliases | ARF-BP1, MULE, LASU1, UREB1 |
| Chromosome | Xp11.22 |
| Protein Type | Ligase |
| Function | It recognizes and ubiquitinates misfolded and damaged proteins for proteasomal degradation, preventing inclusion body formation by rapidly ubiquitinating aggregation-prone species. |
| Primary Expression | the brain throughout development and adulthood, with complex transcriptional regulation by Myc, E2F, and activity-dependent transcription factors[@zho |
| Molecular Weight | 482 kDa |
| Amino Acids | 374 aa |
| Exons | 85 |
| Pathways | mTOR |
| UniProt ID | Q7Z6Z7 |
| NCBI Gene ID | 10075 |
| Ensembl ID | ENSG00000086758 |
| OMIM | 300697 |
| GeneCards | HUWE1 |
| Human Protein Atlas | HUWE1 |
| Associated Diseases | ALS |
| Interactions | IL1B, LC3, MUL1, NLRP3, OPA1, PARL |
| KG Connections | 55 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
HUWE1["HUWE1"] -->|"associated_with"| ALS["ALS"]
HUWE1["HUWE1"] -->|"co_expressed_with"| IL1B["IL1B"]
HUWE1["HUWE1"] -->|"co_expressed_with"| LC3["LC3"]
GSR["GSR"] -->|"co_expressed_with"| HUWE1["HUWE1"]
HIF1A["HIF1A"] -->|"co_expressed_with"| HUWE1["HUWE1"]
HUWE1["HUWE1"] -->|"implicated_in"| neurodegeneration["neurodegeneration"]
style HUWE1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| IL1B | activates | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| MUL1 | activates | gene | 0.60 |
| NLRP3 | activates | gene | 0.60 |
| OPA1 | activates | gene | 0.60 |
| PARL | activates | gene | 0.60 |
| PINK1 | activates | gene | 0.60 |
| PRKN | activates | gene | 0.60 |
| PTEN | activates | gene | 0.60 |
| SLC7A11 | activates | gene | 0.60 |
| SQSTM1 | activates | gene | 0.60 |
| TXN | activates | gene | 0.60 |
| VCP | activates | gene | 0.60 |
| MRAS | activates | gene | 0.60 |
| WIPI2 | interacts_with | gene | 0.60 |
| WIPI2 | activates | gene | 0.60 |
| WIPI2 | regulates | gene | 0.60 |
| TRIM25 | regulates | gene | 0.60 |
| UBE3A | regulates | gene | 0.60 |
| VCP | regulates | gene | 0.60 |
| ALS | associated_with | disease | 0.60 |
| NADPH | activates | gene | 0.60 |
| NIX | activates | gene | 0.60 |
| NLR | activates | gene | 0.60 |
| NOX | activates | gene | 0.60 |
| Wnt signaling | participates_in | pathway | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| apoptosis pathway | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| ROS | activates | gene | 0.60 |
| CRISPR-Cas | participates_in | pathway | 0.60 |
| IL1B | co_expressed_with | gene | 0.50 |
| LC3 | co_expressed_with | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AMBRA1 | activates | gene | 0.60 |
| BAK1 | activates | gene | 0.60 |
| BAX | activates | gene | 0.60 |
| BCL2 | activates | gene | 0.60 |
| BECN1 | activates | gene | 0.60 |
| BNIP3 | activates | gene | 0.60 |
| BNIP3L | activates | gene | 0.60 |
| CASP1 | activates | gene | 0.60 |
| CAT | activates | gene | 0.60 |
| CNP | activates | gene | 0.60 |
| DNM1L | activates | gene | 0.60 |
| DRP1 | activates | gene | 0.60 |
| FUNDC1 | activates | gene | 0.60 |
| GSK3B | activates | gene | 0.60 |
| GSR | activates | gene | 0.60 |
| HIF1A | activates | gene | 0.60 |
| G6PD | activates | gene | 0.60 |
| GSH | activates | gene | 0.60 |
| ATP | activates | gene | 0.60 |
| GSR | co_expressed_with | gene | 0.50 |
| HIF1A | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||