protein

PARL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PARL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

517Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

PARL is a protein involved in neurodegeneration research. Key relationships include: interacts with, implicated in, activates. Associated with AD, ALI, Als. Connected to 190 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	PARL
Chromosome	3q27.1
Protein Type	Protein
Function	OPA1 processing: Cleaves OPA1 (optic atrophy 1) to regulate mitochondrial fusion
Subcellular Localization	** Inner mitochondrial membrane
Molecular Weight	42 kDa
Amino Acids	379 aa
Pathways	Autophagy
UniProt ID	Search UniProt
GeneCards	PARL
Human Protein Atlas	PARL
Associated Diseases	AD, ALI, Als, Alzheimer, Cardiac
Interactions	ABCD3, Actin, AIFM1, ALS, ALZHEIMER, ALZHEIMER DISEASE
KG Connections	517 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PARL — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PARL Protein

protein · 513 words

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Pathway Diagram

graph TD
    PARL["PARL"]
    PARL -->|"interacts"| Alzheimer["Alzheimer"]
    PARL -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    PARL -->|"interacts"| Dementia["Dementia"]
    PARL -->|"interacts"| Cardiovascular["Cardiovascular"]
    PARL -->|"interacts"| Parkinson["Parkinson"]
    PARL -->|"interacts"| EIF2S1["EIF2S1"]
    PARL -->|"interacts"| NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    PARL -->|"interacts"| ALS["ALS"]
    PARL -->|"interacts"| CALCOCO2["CALCOCO2"]
    PARL -->|"interacts"| MIRO1["MIRO1"]
    BCL2L11["BCL2L11"] -->|"interacts"| PARL
    DNA["DNA"] -->|"interacts"| PARL
    NIX["NIX"] -->|"interacts"| PARL
    HIF1["HIF1"] -->|"interacts"| PARL
    RB1["RB1"] -->|"interacts"| PARL
    NLRP3["NLRP3"] -->|"interacts"| PARL
    PARKINSON["PARKINSON"] -->|"interacts"| PARL
    FMR1["FMR1"] -->|"interacts"| PARL
    RB1CC1["RB1CC1"] -->|"interacts"| PARL

Outgoing (243)

Target	Relation	Type	Str
PINK1	associated_with	protein	0.90
Cardiac	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Alzheimer	activates	disease	0.65
Alzheimer	interacts_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Cardiac	implicated_in	disease	0.65
Heart Failure	implicated_in	disease	0.65
Als	associated_with	disease	0.65
SLC7A11	activates	gene	0.60
TXN	activates	gene	0.60
VCP	activates	gene	0.60
Rb	interacts_with	protein	0.60
Parkinson's disease	activates	disease	0.60
Wnt signaling	participates_in	pathway	0.60
PINK1	interacts_with	gene	0.60
PERK	interacts_with	gene	0.60
Alzheimer	associated_with	disease	0.60
PIK3C3	activates	gene	0.60
TOMM20	interacts_with	gene	0.60
TOMM20	activates	entity	0.60
TOMM70	activates	entity	0.60
PHB2	activates	gene	0.60
RB1	activates	gene	0.60
frontotemporal	associated_with	disease	0.60
Mitophagy	interacts_with	pathway	0.60
Apoptosis	interacts_with	pathway	0.60
Autophagy	interacts_with	pathway	0.60
Mapk	interacts_with	pathway	0.60
Cell Cycle	interacts_with	pathway	0.60
frontotemporal dementia	activates	disease	0.60
USP30	implicated_in	gene	0.60
PARKIN	associated_with	gene	0.60
BECN1	activates	gene	0.60
TOMM70	interacts_with	gene	0.60
CPT2	implicated_in	gene	0.60
MIRO1	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
MAPK8	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60

Incoming (274)

Source	Relation	Type	Str
LC3B	activates	gene	0.60
DISC1	activates	entity	0.60
ABCD3	activates	entity	0.60
DNM1L	activates	entity	0.60
DRP1	activates	entity	0.60
BCL2L11	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
AMBRA1	activates	entity	0.60
BNIP3L	activates	entity	0.60
CALCOCO2	activates	entity	0.60
CANX	activates	entity	0.60
CAT	activates	entity	0.60
CHOP	activates	entity	0.60
CTSD	activates	entity	0.60
ERN1	activates	entity	0.60
FAM134B	activates	entity	0.60
FIP200	activates	entity	0.60
FMR1	activates	entity	0.60
FUNDC1	activates	entity	0.60
G3BP1	activates	entity	0.60
GBA	activates	entity	0.60
HIF1A	activates	entity	0.60
JNK	activates	entity	0.60
LC3	activates	entity	0.60
LGALS3	activates	entity	0.60
HIF1	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
LYSOSOME	activates	gene	0.60
CATALASE	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
HIF	activates	gene	0.60
DDIT3	activates	entity	0.60
LMNA	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
MAPK8	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PARL in their description or question text

No additional research found