protein

PARL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PARL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

532Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

PARL is a protein involved in neurodegeneration research. Key relationships include: interacts with, implicated in, activates. Associated with AD, ALI, Als. Connected to 190 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolPARL
Full NamePARL
Chromosome3q27.1
Protein TypeProtein
FunctionOPA1 processing: Cleaves OPA1 (optic atrophy 1) to regulate mitochondrial fusion
Subcellular Localization** Inner mitochondrial membrane
Molecular Weight42 kDa
Amino Acids379 aa
PathwaysAutophagy
UniProt IDSearch UniProt
GeneCardsPARL
Human Protein AtlasPARL
Associated DiseasesAD, ALI, ALS, Alzheimer, Cardiac
InteractionsEIF2S1, CALCOCO2, MIRO1, PTEN, MFN1, PERK
KG Connections532 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: PARL — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (17)

Knowledge base pages for this entity

Canonical Page

PARL Protein

protein · 513 words

Mitochondrial Quality Control

mechanism · 5069 words

mitophagy-defect

mechanism · 3933 words

surf1

gene · 3165 words

PINK1-Parkin Mitophagy Pathway in Parkinson's Disease

mechanism · 2896 words

Mitochondrial Dysfunction in PD

mechanism · 2535 words

Pathway Diagram

graph TD
    PARL["PARL"]
    PARL -->|"interacts"| Alzheimer["Alzheimer"]
    PARL -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    PARL -->|"interacts"| Dementia["Dementia"]
    PARL -->|"interacts"| Cardiovascular["Cardiovascular"]
    PARL -->|"interacts"| Parkinson["Parkinson"]
    PARL -->|"interacts"| EIF2S1["EIF2S1"]
    PARL -->|"interacts"| NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    PARL -->|"interacts"| ALS["ALS"]
    PARL -->|"interacts"| CALCOCO2["CALCOCO2"]
    PARL -->|"interacts"| MIRO1["MIRO1"]
    BCL2L11["BCL2L11"] -->|"interacts"| PARL
    DNA["DNA"] -->|"interacts"| PARL
    NIX["NIX"] -->|"interacts"| PARL
    HIF1["HIF1"] -->|"interacts"| PARL
    RB1["RB1"] -->|"interacts"| PARL
    NLRP3["NLRP3"] -->|"interacts"| PARL
    PARKINSON["PARKINSON"] -->|"interacts"| PARL
    FMR1["FMR1"] -->|"interacts"| PARL
    RB1CC1["RB1CC1"] -->|"interacts"| PARL

Outgoing (252)

TargetRelationTypeStr
PINK1cleavesprotein0.90
Alzheimerinteracts_withdisease0.65
Frontotemporal Dementiainteracts_withdisease0.65
Dementiainteracts_withdisease0.65
Cardiovascularinteracts_withdisease0.65

Incoming (280)

SourceRelationTypeStr
BCL2L11interacts_withgene0.60
RB1interacts_withgene0.60
NLRP3interacts_withgene0.60
FMR1interacts_withgene0.60
RB1CC1interacts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found