Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PARL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PARL is a protein involved in neurodegeneration research. Key relationships include: interacts with, implicated in, activates. Associated with AD, ALI, Als. Connected to 190 entities in the SciDEX knowledge graph.
| Gene Symbol | PARL |
| Full Name | PARL |
| Chromosome | 3q27.1 |
| Protein Type | Protein |
| Function | OPA1 processing: Cleaves OPA1 (optic atrophy 1) to regulate mitochondrial fusion |
| Subcellular Localization | ** Inner mitochondrial membrane |
| Molecular Weight | 42 kDa |
| Amino Acids | 379 aa |
| Pathways | Autophagy |
| UniProt ID | Search UniProt |
| GeneCards | PARL |
| Human Protein Atlas | PARL |
| Associated Diseases | AD, ALI, ALS, Alzheimer, Cardiac |
| Interactions | EIF2S1, CALCOCO2, MIRO1, PTEN, MFN1, PERK |
| KG Connections | 532 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
PARL["PARL"]
PARL -->|"interacts"| Alzheimer["Alzheimer"]
PARL -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
PARL -->|"interacts"| Dementia["Dementia"]
PARL -->|"interacts"| Cardiovascular["Cardiovascular"]
PARL -->|"interacts"| Parkinson["Parkinson"]
PARL -->|"interacts"| EIF2S1["EIF2S1"]
PARL -->|"interacts"| NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
PARL -->|"interacts"| ALS["ALS"]
PARL -->|"interacts"| CALCOCO2["CALCOCO2"]
PARL -->|"interacts"| MIRO1["MIRO1"]
BCL2L11["BCL2L11"] -->|"interacts"| PARL
DNA["DNA"] -->|"interacts"| PARL
NIX["NIX"] -->|"interacts"| PARL
HIF1["HIF1"] -->|"interacts"| PARL
RB1["RB1"] -->|"interacts"| PARL
NLRP3["NLRP3"] -->|"interacts"| PARL
PARKINSON["PARKINSON"] -->|"interacts"| PARL
FMR1["FMR1"] -->|"interacts"| PARL
RB1CC1["RB1CC1"] -->|"interacts"| PARL| Target | Relation | Type | Str |
|---|---|---|---|
| PINK1 | cleaves | protein | 0.90 |
| Alzheimer | interacts_with | disease | 0.65 |
| Frontotemporal Dementia | interacts_with | disease | 0.65 |
| Dementia | interacts_with | disease | 0.65 |
| Cardiovascular | interacts_with | disease | 0.65 |
| Parkinson | interacts_with | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Heart Failure | implicated_in | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Cardiac | implicated_in | disease | 0.65 |
| Alzheimer | activates | disease | 0.65 |
| Cardiac | activates | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| EIF2S1 | interacts_with | gene | 0.60 |
| CALCOCO2 | interacts_with | gene | 0.60 |
| MIRO1 | interacts_with | gene | 0.60 |
| PTEN | interacts_with | gene | 0.60 |
| MFN1 | interacts_with | gene | 0.60 |
| PERK | interacts_with | gene | 0.60 |
| MAP1LC3B | interacts_with | gene | 0.60 |
| BECN1 | interacts_with | gene | 0.60 |
| RHOT1 | interacts_with | gene | 0.60 |
| STING1 | interacts_with | gene | 0.60 |
| LC3 | interacts_with | gene | 0.60 |
| MAPK8 | interacts_with | gene | 0.60 |
| EMD | interacts_with | gene | 0.60 |
| DDIT3 | interacts_with | gene | 0.60 |
| OPTN | interacts_with | gene | 0.60 |
| ERN1 | interacts_with | gene | 0.60 |
| PRKN | interacts_with | gene | 0.60 |
| ATM | interacts_with | gene | 0.60 |
| PARKIN | interacts_with | gene | 0.60 |
| MUL1 | interacts_with | gene | 0.60 |
| NDP52 | interacts_with | gene | 0.60 |
| BCL2L13 | interacts_with | gene | 0.60 |
| SNCA | interacts_with | gene | 0.60 |
| GBA | interacts_with | gene | 0.60 |
| DRP1 | interacts_with | gene | 0.60 |
| EIF2AK3 | interacts_with | gene | 0.60 |
| CANX | interacts_with | gene | 0.60 |
| UBIQUITIN | interacts_with | gene | 0.60 |
| DNM1L | interacts_with | gene | 0.60 |
| CTSD | interacts_with | gene | 0.60 |
| HIF1A | interacts_with | gene | 0.60 |
| BNIP3L | interacts_with | gene | 0.60 |
| AMBRA1 | interacts_with | gene | 0.60 |
| ABCD3 | interacts_with | gene | 0.60 |
| NBR1 | interacts_with | gene | 0.60 |
| TAX1BP1 | interacts_with | gene | 0.60 |
| OPTINEURIN | interacts_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BCL2L11 | interacts_with | gene | 0.60 |
| RB1 | interacts_with | gene | 0.60 |
| NLRP3 | interacts_with | gene | 0.60 |
| FMR1 | interacts_with | gene | 0.60 |
| RB1CC1 | interacts_with | gene | 0.60 |
| P62 | interacts_with | gene | 0.60 |
| DISC1 | interacts_with | gene | 0.60 |
| MAP1LC3B | interacts_with | gene | 0.60 |
| CTSD | interacts_with | gene | 0.60 |
| PRKN | interacts_with | gene | 0.60 |
| CALCOCO2 | interacts_with | gene | 0.60 |
| EPAS1 | interacts_with | gene | 0.60 |
| SQSTM1 | interacts_with | gene | 0.60 |
| MAPK8 | interacts_with | gene | 0.60 |
| PINK1 | interacts_with | gene | 0.60 |
| CAT | interacts_with | gene | 0.60 |
| BECN1 | interacts_with | gene | 0.60 |
| UBIQUITIN | interacts_with | gene | 0.60 |
| SNCA | interacts_with | gene | 0.60 |
| LC3 | interacts_with | gene | 0.60 |
| LMNA | interacts_with | gene | 0.60 |
| EMD | interacts_with | gene | 0.60 |
| MIRO1 | interacts_with | gene | 0.60 |
| PTEN | interacts_with | gene | 0.60 |
| SESN2 | interacts_with | gene | 0.60 |
| FUNDC1 | interacts_with | gene | 0.60 |
| DDIT3 | interacts_with | gene | 0.60 |
| JNK | interacts_with | gene | 0.60 |
| RTN3 | interacts_with | gene | 0.60 |
| EIF2AK3 | interacts_with | gene | 0.60 |
| DRP1 | interacts_with | gene | 0.60 |
| CANX | interacts_with | gene | 0.60 |
| RIPK3 | interacts_with | gene | 0.60 |
| RHOT1 | interacts_with | gene | 0.60 |
| AMBRA1 | interacts_with | gene | 0.60 |
| MUL1 | interacts_with | gene | 0.60 |
| HIF1A | interacts_with | gene | 0.60 |
| STING1 | interacts_with | gene | 0.60 |
| OPTINEURIN | interacts_with | gene | 0.60 |
| FIP200 | interacts_with | gene | 0.60 |
| PERK | interacts_with | gene | 0.60 |
| SNCAIP | interacts_with | gene | 0.60 |
| EIF2S1 | interacts_with | gene | 0.60 |
| PARKIN | interacts_with | gene | 0.60 |
| GBA | interacts_with | gene | 0.60 |
| OPTN | interacts_with | gene | 0.60 |
| CHOP | interacts_with | gene | 0.60 |
| ERN1 | interacts_with | gene | 0.60 |
| DNM1L | interacts_with | gene | 0.60 |
| ABCD3 | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||