AMPK

Understanding Entity Pages

This page aggregates everything SciDEX knows about AMPK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

AMPK is a protein involved in neurodegeneration research. Key relationships include: activates, associated with, interacts with. Associated with AD, ALI, ALS. Connected to 2284 entities in the SciDEX knowledge graph.

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graph TD
    subgraph Signaling["Signaling"]
        AMPK["AMPK"] -->|"activates"| ULK1["ULK1"]
        AMPK["AMPK"] -->|"activates"| AUTOPHAGY["AUTOPHAGY"]
        AMPK["AMPK"] -->|"regulates"| ULK1_1["ULK1"]
        AMPK["AMPK"] -->|"regulates"| Autophagy["Autophagy"]
        AMPK["AMPK"] -->|"activates"| Cancer["Cancer"]
        AMPK["AMPK"] -->|"activates"| Tumor["Tumor"]
        AMPK["AMPK"] -->|"activates"| Glycolysis["Glycolysis"]
        AMPK["AMPK"] -->|"activates"| Mtor["Mtor"]
        SIRT1["SIRT1"] -->|"activates"| AMPK["AMPK"]
        PI3K["PI3K"] -->|"activates"| AMPK["AMPK"]
        TNF["TNF"] -->|"activates"| AMPK["AMPK"]
        PINK1["PINK1"] -->|"activates"| AMPK["AMPK"]
        AUTOPHAGY_2["AUTOPHAGY"] -->|"activates"| AMPK["AMPK"]
        INFLAMMATION["INFLAMMATION"] -->|"activates"| AMPK["AMPK"]
    end
    subgraph Therapeutic["Therapeutic"]
        AMPK["AMPK"] -->|"therapeutic target"| Als["Als"]
    end
    style AMPK fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
    style ULK1 fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AUTOPHAGY fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ULK1_1 fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Autophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Glycolysis fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Mtor fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Als fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style SIRT1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style PI3K fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style TNF fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style PINK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AUTOPHAGY_2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style INFLAMMATION fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0