Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TIMM10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | TIMM10 |
| Full Name | Mitochondrial Import Inner Membrane Translocase Subunit Tim10 |
| Function | TIMM10 (Translocase of Inner Mitochondrial Membrane 10) is a small essential subunit of the TIM22 complex, which mediates the insertion of carrier proteins into the inner mitochondrial membrane. |
| Primary Expression | neurons throughout the CNS - Regional Distribution: High expression in basal ganglia, hippocampus, and motor [cortex |
| Pathways | Unfolded Protein Response, Mitophagy, Mtor |
| GeneCards | TIMM10 |
| Human Protein Atlas | TIMM10 |
| Cellular respiration | Proper assembly of the electron transport chain |
| Metabolic regulation | Transport of substrates and products |
| Calcium homeostasis | Mitochondrial calcium uptake |
| [Apoptosis](/entities/apoptosis) | Release of cytochrome c and other pro-apoptotic factors [2] |
| Brain | Widely expressed in neurons throughout the CNS |
| Regional Distribution | High expression in basal ganglia, hippocampus, and motor cortex |
| Upregulation | Induced during mitochondrial biogenesis and in response to mitochondrial stress |
| Cellular Localization | Mitochondrial intermembrane space |
| Associated Diseases | neurodegeneration |
| Interactions | DNM1L, BNIP3, VDAC1, FUNDC1, TOMM20, TIMM9 |
| KG Connections | 43 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TIMM10["<b>TIMM10</b>"]
Heart_Failure{"Heart Failure"}
TIMM10 -->|"inhibits"| Heart_Failure
Ms{"Ms"}
TIMM10 -->|"inhibits"| Ms
DNM1L["DNM1L"]
TIMM10 -->|"inhibits"| DNM1L
Unfolded_Protein_Response(["Unfolded Protein Response"])
TIMM10 -->|"inhibits"| Unfolded_Protein_Response
Mitophagy(["Mitophagy"])
TIMM10 -->|"inhibits"| Mitophagy
Mtor(["Mtor"])
TIMM10 -->|"inhibits"| Mtor
neurodegeneration["neurodegeneration"]
TIMM10 -->|"implicated in"| neurodegeneration
BNIP3["BNIP3"]
BNIP3 -->|"inhibits"| TIMM10
VDAC1["VDAC1"]
VDAC1 -->|"inhibits"| TIMM10
FUNDC1["FUNDC1"]
FUNDC1 -->|"inhibits"| TIMM10
TOMM20["TOMM20"]
TOMM20 -->|"inhibits"| TIMM10
TIMM9["TIMM9"]
TIMM9 -->|"inhibits"| TIMM10
TIMM17B["TIMM17B"]
TIMM17B -->|"inhibits"| TIMM10
OMA1["OMA1"]
OMA1 -->|"inhibits"| TIMM10
TIMM23["TIMM23"]
TIMM23 -->|"inhibits"| TIMM10
MTOR["MTOR"]
MTOR -->|"inhibits"| TIMM10
NRF1["NRF1"]
NRF1 -->|"inhibits"| TIMM10
HSPD1["HSPD1"]
HSPD1 -->|"inhibits"| TIMM10
MFN2["MFN2"]
MFN2 -->|"inhibits"| TIMM10
style TIMM10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Heart Failure | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| DNM1L | inhibits | gene | 0.60 |
| Unfolded Protein Response | inhibits | pathway | 0.60 |
| Mitophagy | inhibits | pathway | 0.60 |
| Mtor | inhibits | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BNIP3 | inhibits | gene | 0.60 |
| VDAC1 | inhibits | gene | 0.60 |
| FUNDC1 | inhibits | gene | 0.60 |
| TOMM20 | inhibits | gene | 0.60 |
| TIMM9 | inhibits | gene | 0.60 |
| TIMM17B | inhibits | gene | 0.60 |
| OMA1 | inhibits | gene | 0.60 |
| TIMM23 | inhibits | gene | 0.60 |
| MTOR | inhibits | gene | 0.60 |
| NRF1 | inhibits | gene | 0.60 |
| HSPD1 | inhibits | gene | 0.60 |
| MFN2 | inhibits | gene | 0.60 |
| MFF | inhibits | gene | 0.60 |
| BECN1 | inhibits | gene | 0.60 |
| LONP1 | inhibits | gene | 0.60 |
| CEBPB | inhibits | gene | 0.60 |
| SPG7 | inhibits | gene | 0.60 |
| MAP1LC3A | inhibits | gene | 0.60 |
| DDIT3 | inhibits | gene | 0.60 |
| JUN | inhibits | gene | 0.60 |
| TIMM50 | inhibits | gene | 0.60 |
| HSPA9 | inhibits | gene | 0.60 |
| TIMM22 | inhibits | gene | 0.60 |
| HSPE1 | inhibits | gene | 0.60 |
| OPA1 | inhibits | gene | 0.60 |
| LAMP2 | inhibits | gene | 0.60 |
| BNIP3L | inhibits | gene | 0.60 |
| SIRT1 | inhibits | gene | 0.60 |
| HTRA2 | inhibits | gene | 0.60 |
| PARK2 | inhibits | gene | 0.60 |
| PINK1 | inhibits | gene | 0.60 |
| TIMM17A | inhibits | gene | 0.60 |
| EIF2A | inhibits | gene | 0.60 |
| TFAM | inhibits | gene | 0.60 |
| ULK1 | inhibits | gene | 0.60 |
| MITOPHAGY | inhibits | gene | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||