gene

TIMM10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TIMM10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections
0Hypotheses
0Analyses
6Outgoing
37Incoming

Summary

TIMM10 — Mitochondrial Import Inner Membrane Translocase Subunit Tim10

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🧬 Gene Info
Gene SymbolTIMM10
Full NameMitochondrial Import Inner Membrane Translocase Subunit Tim10
FunctionTIMM10 (Translocase of Inner Mitochondrial Membrane 10) is a small essential subunit of the TIM22 complex, which mediates the insertion of carrier proteins into the inner mitochondrial membrane.
Primary Expressionneurons throughout the CNS - Regional Distribution: High expression in basal ganglia, hippocampus, and motor [cortex
PathwaysUnfolded Protein Response, Mitophagy, Mtor
GeneCardsTIMM10
Human Protein AtlasTIMM10
Cellular respirationProper assembly of the electron transport chain
Metabolic regulationTransport of substrates and products
Calcium homeostasisMitochondrial calcium uptake
[Apoptosis](/entities/apoptosis)Release of cytochrome c and other pro-apoptotic factors [2]
BrainWidely expressed in neurons throughout the CNS
Regional DistributionHigh expression in basal ganglia, hippocampus, and motor cortex
UpregulationInduced during mitochondrial biogenesis and in response to mitochondrial stress
Cellular LocalizationMitochondrial intermembrane space
Associated Diseasesneurodegeneration
InteractionsDNM1L, BNIP3, VDAC1, FUNDC1, TOMM20, TIMM9
KG Connections43 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

TIMM10 — Mitochondrial Import Inner Membrane Translocase Subunit Tim10

gene · 592 words

timm17a

gene · 2702 words

TIMM13 Gene

gene · 2289 words

TIMM8A Gene

gene · 2039 words

TIMM9

gene · 1695 words

TIMM10B (Translocase of Inner Mitochondrial Membrane 10 Homolog B)

gene · 1536 words

Pathway Diagram

graph TD
    TIMM10["<b>TIMM10</b>"]
    Heart_Failure{"Heart Failure"}
    TIMM10 -->|"inhibits"| Heart_Failure
    Ms{"Ms"}
    TIMM10 -->|"inhibits"| Ms
    DNM1L["DNM1L"]
    TIMM10 -->|"inhibits"| DNM1L
    Unfolded_Protein_Response(["Unfolded Protein Response"])
    TIMM10 -->|"inhibits"| Unfolded_Protein_Response
    Mitophagy(["Mitophagy"])
    TIMM10 -->|"inhibits"| Mitophagy
    Mtor(["Mtor"])
    TIMM10 -->|"inhibits"| Mtor
    neurodegeneration["neurodegeneration"]
    TIMM10 -->|"implicated in"| neurodegeneration
    BNIP3["BNIP3"]
    BNIP3 -->|"inhibits"| TIMM10
    VDAC1["VDAC1"]
    VDAC1 -->|"inhibits"| TIMM10
    FUNDC1["FUNDC1"]
    FUNDC1 -->|"inhibits"| TIMM10
    TOMM20["TOMM20"]
    TOMM20 -->|"inhibits"| TIMM10
    TIMM9["TIMM9"]
    TIMM9 -->|"inhibits"| TIMM10
    TIMM17B["TIMM17B"]
    TIMM17B -->|"inhibits"| TIMM10
    OMA1["OMA1"]
    OMA1 -->|"inhibits"| TIMM10
    TIMM23["TIMM23"]
    TIMM23 -->|"inhibits"| TIMM10
    MTOR["MTOR"]
    MTOR -->|"inhibits"| TIMM10
    NRF1["NRF1"]
    NRF1 -->|"inhibits"| TIMM10
    HSPD1["HSPD1"]
    HSPD1 -->|"inhibits"| TIMM10
    MFN2["MFN2"]
    MFN2 -->|"inhibits"| TIMM10
    style TIMM10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (6)

TargetRelationTypeStr
Heart Failureinhibitsdisease0.65
Msinhibitsdisease0.65
DNM1Linhibitsgene0.60
Unfolded Protein Responseinhibitspathway0.60
Mitophagyinhibitspathway0.60

Incoming (37)

SourceRelationTypeStr
BNIP3inhibitsgene0.60
VDAC1inhibitsgene0.60
FUNDC1inhibitsgene0.60
TOMM20inhibitsgene0.60
TIMM9inhibitsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found