gene

TIMM23

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TIMM23: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

85Connections
0Hypotheses
0Analyses
50Outgoing
33Incoming

Summary

Page for TIMM23 — Translocase of Inner Mitochondrial Membrane 23

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🧬 Gene Info
Gene SymbolTIMM23
Full NameTranslocase of Inner Mitochondrial Membrane 23
Chromosome10q11.21
FunctionThe TIM23 complex operates in conjunction with the TOM (Translocase of Outer Mitochondrial Membrane) complex, which recognizes and imports precursor proteins across the outer membrane.
Primary ExpressionHigh in brain, heart, muscle, kidney
Amino Acids222 aa
PathwaysMitophagy
UniProt IDO00231
NCBI Gene ID10098
Ensembl IDENSG00000132268
GeneCardsTIMM23
Human Protein AtlasTIMM23
Partner ProteinFunction
TIMM17A/BRegulatory subunit, controls channel activity
TIMM44Motor attachment, recruits mtHsp70
Associated DiseasesParkinson
InteractionsCALCOCO2, PARKIN, PRKN, NDP52, HSPD1, MTOR
KG Connections85 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: TIMM23 — AlphaFold O00231 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

TIMM23 — Translocase of Inner Mitochondrial Membrane 23

gene · 1951 words

Synaptic Dysfunction in 4R-Tauopathies

mechanism · 2091 words

TOMM40L — Translocase of Outer Mitochondrial Membrane 40 Like

gene · 1866 words

TIMM21 — Translocase of Inner Mitochondrial Membrane 21

gene · 1855 words

TIMM17B — Translocase of Inner Mitochondrial Membrane 17B

gene · 1615 words

TIM23 Protein (Translocase of Inner Mitochondrial Membrane 23)

protein · 1557 words

Pathway Diagram

graph TD
    TIMM23["<b>TIMM23</b>"]
    Heart_Failure{"Heart Failure"}
    TIMM23 -->|"inhibits"| Heart_Failure
    Ms{"Ms"}
    TIMM23 -->|"inhibits"| Ms
    CALCOCO2["CALCOCO2"]
    TIMM23 -->|"interacts with"| CALCOCO2
    PARKIN["PARKIN"]
    TIMM23 -->|"interacts with"| PARKIN
    PRKN["PRKN"]
    TIMM23 -->|"interacts with"| PRKN
    NDP52["NDP52"]
    TIMM23 -->|"interacts with"| NDP52
    AMPK["AMPK"]
    TIMM23 -->|"interacts with"| AMPK
    HSPD1["HSPD1"]
    TIMM23 -->|"interacts with"| HSPD1
    Epigenetic(["Epigenetic"])
    TIMM23 -->|"interacts with"| Epigenetic
    Mitophagy(["Mitophagy"])
    TIMM23 -->|"regulates"| Mitophagy
    MTOR["MTOR"]
    TIMM23 -->|"inhibits"| MTOR
    NRF1["NRF1"]
    TIMM23 -->|"inhibits"| NRF1
    PTEN["PTEN"]
    PTEN -->|"interacts with"| TIMM23
    OPTN["OPTN"]
    OPTN -->|"interacts with"| TIMM23
    PINK1["PINK1"]
    PINK1 -->|"interacts with"| TIMM23
    TOMM20["TOMM20"]
    TOMM20 -->|"interacts with"| TIMM23
    BNIP3["BNIP3"]
    BNIP3 -->|"inhibits"| TIMM23
    VDAC1["VDAC1"]
    VDAC1 -->|"inhibits"| TIMM23
    FUNDC1["FUNDC1"]
    FUNDC1 -->|"inhibits"| TIMM23
    TOMM20 -->|"inhibits"| TIMM23
    TIMM9["TIMM9"]
    TIMM9 -->|"inhibits"| TIMM23
    TIMM17B["TIMM17B"]
    TIMM17B -->|"inhibits"| TIMM23
    OMA1["OMA1"]
    OMA1 -->|"inhibits"| TIMM23
    style TIMM23 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (52)

TargetRelationTypeStr
Heart Failureinhibitsdisease0.65
Msinhibitsdisease0.65
CALCOCO2interacts_withgene0.60
PARKINinteracts_withgene0.60
PRKNinteracts_withgene0.60

Incoming (33)

SourceRelationTypeStr
PTENinteracts_withgene0.60
OPTNinteracts_withgene0.60
PINK1interacts_withgene0.60
TOMM20interacts_withgene0.60
BNIP3inhibitsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found