Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TIMM23: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | TIMM23 |
| Full Name | Translocase of Inner Mitochondrial Membrane 23 |
| Chromosome | 10q11.21 |
| Function | The TIM23 complex operates in conjunction with the TOM (Translocase of Outer Mitochondrial Membrane) complex, which recognizes and imports precursor proteins across the outer membrane. |
| Primary Expression | High in brain, heart, muscle, kidney |
| Amino Acids | 222 aa |
| Pathways | Mitophagy |
| UniProt ID | O00231 |
| NCBI Gene ID | 10098 |
| Ensembl ID | ENSG00000132268 |
| GeneCards | TIMM23 |
| Human Protein Atlas | TIMM23 |
| Partner Protein | Function |
| TIMM17A/B | Regulatory subunit, controls channel activity |
| TIMM44 | Motor attachment, recruits mtHsp70 |
| Associated Diseases | Parkinson |
| Interactions | CALCOCO2, PARKIN, PRKN, NDP52, HSPD1, MTOR |
| KG Connections | 85 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
TIMM23["<b>TIMM23</b>"]
Heart_Failure{"Heart Failure"}
TIMM23 -->|"inhibits"| Heart_Failure
Ms{"Ms"}
TIMM23 -->|"inhibits"| Ms
CALCOCO2["CALCOCO2"]
TIMM23 -->|"interacts with"| CALCOCO2
PARKIN["PARKIN"]
TIMM23 -->|"interacts with"| PARKIN
PRKN["PRKN"]
TIMM23 -->|"interacts with"| PRKN
NDP52["NDP52"]
TIMM23 -->|"interacts with"| NDP52
AMPK["AMPK"]
TIMM23 -->|"interacts with"| AMPK
HSPD1["HSPD1"]
TIMM23 -->|"interacts with"| HSPD1
Epigenetic(["Epigenetic"])
TIMM23 -->|"interacts with"| Epigenetic
Mitophagy(["Mitophagy"])
TIMM23 -->|"regulates"| Mitophagy
MTOR["MTOR"]
TIMM23 -->|"inhibits"| MTOR
NRF1["NRF1"]
TIMM23 -->|"inhibits"| NRF1
PTEN["PTEN"]
PTEN -->|"interacts with"| TIMM23
OPTN["OPTN"]
OPTN -->|"interacts with"| TIMM23
PINK1["PINK1"]
PINK1 -->|"interacts with"| TIMM23
TOMM20["TOMM20"]
TOMM20 -->|"interacts with"| TIMM23
BNIP3["BNIP3"]
BNIP3 -->|"inhibits"| TIMM23
VDAC1["VDAC1"]
VDAC1 -->|"inhibits"| TIMM23
FUNDC1["FUNDC1"]
FUNDC1 -->|"inhibits"| TIMM23
TOMM20 -->|"inhibits"| TIMM23
TIMM9["TIMM9"]
TIMM9 -->|"inhibits"| TIMM23
TIMM17B["TIMM17B"]
TIMM17B -->|"inhibits"| TIMM23
OMA1["OMA1"]
OMA1 -->|"inhibits"| TIMM23
style TIMM23 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Heart Failure | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| CALCOCO2 | interacts_with | gene | 0.60 |
| PARKIN | interacts_with | gene | 0.60 |
| PRKN | interacts_with | gene | 0.60 |
| NDP52 | interacts_with | gene | 0.60 |
| HSPD1 | interacts_with | gene | 0.60 |
| MTOR | inhibits | gene | 0.60 |
| NRF1 | inhibits | gene | 0.60 |
| HSPD1 | inhibits | gene | 0.60 |
| MFN2 | inhibits | gene | 0.60 |
| MFF | inhibits | gene | 0.60 |
| BECN1 | inhibits | gene | 0.60 |
| LONP1 | inhibits | gene | 0.60 |
| CEBPB | inhibits | gene | 0.60 |
| SPG7 | inhibits | gene | 0.60 |
| MAP1LC3A | inhibits | gene | 0.60 |
| DDIT3 | inhibits | gene | 0.60 |
| JUN | inhibits | gene | 0.60 |
| TIMM50 | inhibits | gene | 0.60 |
| HSPA9 | inhibits | gene | 0.60 |
| TIMM22 | inhibits | gene | 0.60 |
| HSPE1 | inhibits | gene | 0.60 |
| OPA1 | inhibits | gene | 0.60 |
| LAMP2 | inhibits | gene | 0.60 |
| BNIP3L | inhibits | gene | 0.60 |
| SIRT1 | inhibits | gene | 0.60 |
| HTRA2 | inhibits | gene | 0.60 |
| PARK2 | inhibits | gene | 0.60 |
| PINK1 | inhibits | gene | 0.60 |
| TIMM17A | inhibits | gene | 0.60 |
| EIF2A | inhibits | gene | 0.60 |
| TFAM | inhibits | gene | 0.60 |
| ULK1 | inhibits | gene | 0.60 |
| TIMM10 | inhibits | gene | 0.60 |
| DNM1L | inhibits | gene | 0.60 |
| TMEM59 | activates | gene | 0.60 |
| TOMM20 | activates | gene | 0.60 |
| AMPK | interacts_with | gene | 0.60 |
| Epigenetic | interacts_with | pathway | 0.60 |
| Mitophagy | regulates | pathway | 0.60 |
| MITOPHAGY | inhibits | gene | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | inhibits | gene | 0.60 |
| Unfolded Protein Response | inhibits | pathway | 0.60 |
| Mitophagy | inhibits | pathway | 0.60 |
| Mtor | inhibits | pathway | 0.60 |
| Parkinson | associated_with | disease | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| apoptosis pathway | participates_in | pathway | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PTEN | interacts_with | gene | 0.60 |
| OPTN | interacts_with | gene | 0.60 |
| PINK1 | interacts_with | gene | 0.60 |
| TOMM20 | interacts_with | gene | 0.60 |
| BNIP3 | inhibits | gene | 0.60 |
| VDAC1 | inhibits | gene | 0.60 |
| FUNDC1 | inhibits | gene | 0.60 |
| TOMM20 | inhibits | gene | 0.60 |
| TIMM9 | inhibits | gene | 0.60 |
| TIMM17B | inhibits | gene | 0.60 |
| OMA1 | inhibits | gene | 0.60 |
| ABP | activates | gene | 0.60 |
| ATG16L1 | activates | gene | 0.60 |
| BCL2 | activates | gene | 0.60 |
| CALCOCO2 | activates | gene | 0.60 |
| CASP3 | activates | gene | 0.60 |
| GAPDH | activates | gene | 0.60 |
| HTT | activates | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| MFF | activates | gene | 0.60 |
| NBR1 | activates | gene | 0.60 |
| NDP52 | activates | gene | 0.60 |
| NLRX1 | activates | gene | 0.60 |
| OPTN | activates | gene | 0.60 |
| PINK1 | activates | gene | 0.60 |
| PRKN | activates | gene | 0.60 |
| PTEN | activates | gene | 0.60 |
| DMSO | activates | gene | 0.60 |
| GFP | activates | gene | 0.60 |
| MAP1LC3 | activates | gene | 0.60 |
| NLR | activates | gene | 0.60 |
| PRKN | co_expressed_with | gene | 0.50 |
| PTEN | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||