Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TIMM9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Translocase of Inner Mitochondrial Membrane 9 - chaperone protein essential for mitochondrial protein import
| Gene Symbol | TIMM9 |
| Aliases | Translocase of Inner Mitochondrial Membrane 9 |
| Protein Type | Chaperone |
| Function | is a small chaperone protein localized in the mitochondrial intermembrane space. |
| Subcellular Localization | the mitochondrial intermembrane space. It plays an essential role in the import and insertion of proteins into the inner |
| Molecular Weight | 10 kDa |
| Amino Acids | 88 aa |
| Pathways | Unfolded Protein Response, Mitophagy, Mtor |
| GeneCards | TIMM9 |
| Human Protein Atlas | TIMM9 |
| TIMM10 | Chaperone complex subunit |
| TIMM22 | TIM22 translocase core component |
| TIMM8A/B | Small Tim family members |
| TOMM40 | Outer membrane translocase component |
| Mitochondrial carrier proteins | Substrate precursors |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | TIMM17B, OMA1, TIMM23, MTOR, NRF1, HSPD1 |
| KG Connections | 43 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TIMM9["<b>TIMM9</b>"]
Heart_Failure{"Heart Failure"}
TIMM9 -->|"inhibits"| Heart_Failure
Ms{"Ms"}
TIMM9 -->|"inhibits"| Ms
TIMM17B["TIMM17B"]
TIMM9 -->|"inhibits"| TIMM17B
OMA1["OMA1"]
TIMM9 -->|"inhibits"| OMA1
TIMM23["TIMM23"]
TIMM9 -->|"inhibits"| TIMM23
MTOR["MTOR"]
TIMM9 -->|"inhibits"| MTOR
NRF1["NRF1"]
TIMM9 -->|"inhibits"| NRF1
HSPD1["HSPD1"]
TIMM9 -->|"inhibits"| HSPD1
MFN2["MFN2"]
TIMM9 -->|"inhibits"| MFN2
MFF["MFF"]
TIMM9 -->|"inhibits"| MFF
BECN1["BECN1"]
TIMM9 -->|"inhibits"| BECN1
LONP1["LONP1"]
TIMM9 -->|"inhibits"| LONP1
BNIP3["BNIP3"]
BNIP3 -->|"inhibits"| TIMM9
VDAC1["VDAC1"]
VDAC1 -->|"inhibits"| TIMM9
FUNDC1["FUNDC1"]
FUNDC1 -->|"inhibits"| TIMM9
TOMM20["TOMM20"]
TOMM20 -->|"inhibits"| TIMM9
style TIMM9 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Heart Failure | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| TIMM17B | inhibits | gene | 0.60 |
| OMA1 | inhibits | gene | 0.60 |
| TIMM23 | inhibits | gene | 0.60 |
| MTOR | inhibits | gene | 0.60 |
| NRF1 | inhibits | gene | 0.60 |
| HSPD1 | inhibits | gene | 0.60 |
| MFN2 | inhibits | gene | 0.60 |
| MFF | inhibits | gene | 0.60 |
| BECN1 | inhibits | gene | 0.60 |
| LONP1 | inhibits | gene | 0.60 |
| CEBPB | inhibits | gene | 0.60 |
| SPG7 | inhibits | gene | 0.60 |
| MAP1LC3A | inhibits | gene | 0.60 |
| DDIT3 | inhibits | gene | 0.60 |
| JUN | inhibits | gene | 0.60 |
| TIMM50 | inhibits | gene | 0.60 |
| HSPA9 | inhibits | gene | 0.60 |
| TIMM22 | inhibits | gene | 0.60 |
| HSPE1 | inhibits | gene | 0.60 |
| OPA1 | inhibits | gene | 0.60 |
| LAMP2 | inhibits | gene | 0.60 |
| BNIP3L | inhibits | gene | 0.60 |
| SIRT1 | inhibits | gene | 0.60 |
| HTRA2 | inhibits | gene | 0.60 |
| PARK2 | inhibits | gene | 0.60 |
| PINK1 | inhibits | gene | 0.60 |
| TIMM17A | inhibits | gene | 0.60 |
| EIF2A | inhibits | gene | 0.60 |
| TFAM | inhibits | gene | 0.60 |
| ULK1 | inhibits | gene | 0.60 |
| TIMM10 | inhibits | gene | 0.60 |
| DNM1L | inhibits | gene | 0.60 |
| MITOPHAGY | inhibits | gene | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | inhibits | gene | 0.60 |
| Unfolded Protein Response | inhibits | pathway | 0.60 |
| Mitophagy | inhibits | pathway | 0.60 |
| Mtor | inhibits | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||