gene

TIMM22

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TIMM22: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections
0Hypotheses
0Analyses
21Outgoing
22Incoming

Summary

TIMM22 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, implicated in. Associated with Heart Failure, Ms. Connected to 44 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolTIMM22
Chromosome17p13.2
Protein FamilyTranslocase of inner mitochondrial membrane (TIM) family
Protein TypeMitochondrial Inner Membrane Translocase
Functionis an essential component of the TIM22 complex, which mediates the insertion of carrier proteins into the mitochondrial inner membrane.
Primary ExpressionMitochondrial inner membrane
Subcellular LocalizationMitochondrial inner membrane
Molecular Weight~25 kDa
Amino Acids227 aa
UniProt IDQ9Y5J7
NCBI Gene ID94081
Ensembl IDENSG00000139350
GeneCardsTIMM22
Human Protein AtlasTIMM22
Gene NameTranslocase of Inner Mitochondrial Membrane 22
Associated DiseasesParkinson's Disease, Mitochondrial Disorders
InteractionsHSPE1, OPA1, LAMP2, BNIP3L, SIRT1, HTRA2
KG Connections43 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: TIMM22 — AlphaFold Q9Y5J7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

TIMM22 Gene - Translocase of Inner Mitochondrial Membrane 22

gene · 1184 words

timm17a

gene · 2702 words

TIMM23 — Translocase of Inner Mitochondrial Membrane 23

gene · 1951 words

TIMM21 — Translocase of Inner Mitochondrial Membrane 21

gene · 1855 words

TIMM9

gene · 1695 words

TIMM17B — Translocase of Inner Mitochondrial Membrane 17B

gene · 1615 words

Pathway Diagram

graph TD
    TIMM22["<b>TIMM22</b>"]
    Heart_Failure{"Heart Failure"}
    TIMM22 -->|"inhibits"| Heart_Failure
    Ms{"Ms"}
    TIMM22 -->|"inhibits"| Ms
    MITOPHAGY["MITOPHAGY"]
    TIMM22 -->|"inhibits"| MITOPHAGY
    HSPE1["HSPE1"]
    TIMM22 -->|"inhibits"| HSPE1
    OPA1["OPA1"]
    TIMM22 -->|"inhibits"| OPA1
    LAMP2["LAMP2"]
    TIMM22 -->|"inhibits"| LAMP2
    BNIP3L["BNIP3L"]
    TIMM22 -->|"inhibits"| BNIP3L
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    TIMM22 -->|"inhibits"| MITOCHONDRIAL_DYSFUNCTION
    SIRT1["SIRT1"]
    TIMM22 -->|"inhibits"| SIRT1
    HTRA2["HTRA2"]
    TIMM22 -->|"inhibits"| HTRA2
    PARK2["PARK2"]
    TIMM22 -->|"inhibits"| PARK2
    PINK1["PINK1"]
    TIMM22 -->|"inhibits"| PINK1
    BNIP3["BNIP3"]
    BNIP3 -->|"inhibits"| TIMM22
    VDAC1["VDAC1"]
    VDAC1 -->|"inhibits"| TIMM22
    FUNDC1["FUNDC1"]
    FUNDC1 -->|"inhibits"| TIMM22
    TOMM20["TOMM20"]
    TOMM20 -->|"inhibits"| TIMM22
    TIMM9["TIMM9"]
    TIMM9 -->|"inhibits"| TIMM22
    TIMM17B["TIMM17B"]
    TIMM17B -->|"inhibits"| TIMM22
    OMA1["OMA1"]
    OMA1 -->|"inhibits"| TIMM22
    TIMM23["TIMM23"]
    TIMM23 -->|"inhibits"| TIMM22
    MTOR["MTOR"]
    MTOR -->|"inhibits"| TIMM22
    NRF1["NRF1"]
    NRF1 -->|"inhibits"| TIMM22
    HSPD1["HSPD1"]
    HSPD1 -->|"inhibits"| TIMM22
    MFN2["MFN2"]
    MFN2 -->|"inhibits"| TIMM22
    style TIMM22 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (21)

TargetRelationTypeStr
Heart Failureinhibitsdisease0.65
Msinhibitsdisease0.65
HSPE1inhibitsgene0.60
OPA1inhibitsgene0.60
LAMP2inhibitsgene0.60

Incoming (22)

SourceRelationTypeStr
BNIP3inhibitsgene0.60
VDAC1inhibitsgene0.60
FUNDC1inhibitsgene0.60
TOMM20inhibitsgene0.60
TIMM9inhibitsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found