Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TIMM22: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TIMM22 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, implicated in. Associated with Heart Failure, Ms. Connected to 44 entities in the SciDEX knowledge graph.
| Gene Symbol | TIMM22 |
| Chromosome | 17p13.2 |
| Protein Family | Translocase of inner mitochondrial membrane (TIM) family |
| Protein Type | Mitochondrial Inner Membrane Translocase |
| Function | is an essential component of the TIM22 complex, which mediates the insertion of carrier proteins into the mitochondrial inner membrane. |
| Primary Expression | Mitochondrial inner membrane |
| Subcellular Localization | Mitochondrial inner membrane |
| Molecular Weight | ~25 kDa |
| Amino Acids | 227 aa |
| UniProt ID | Q9Y5J7 |
| NCBI Gene ID | 94081 |
| Ensembl ID | ENSG00000139350 |
| GeneCards | TIMM22 |
| Human Protein Atlas | TIMM22 |
| Gene Name | Translocase of Inner Mitochondrial Membrane 22 |
| Associated Diseases | Parkinson's Disease, Mitochondrial Disorders |
| Interactions | HSPE1, OPA1, LAMP2, BNIP3L, SIRT1, HTRA2 |
| KG Connections | 43 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
TIMM22["<b>TIMM22</b>"]
Heart_Failure{"Heart Failure"}
TIMM22 -->|"inhibits"| Heart_Failure
Ms{"Ms"}
TIMM22 -->|"inhibits"| Ms
MITOPHAGY["MITOPHAGY"]
TIMM22 -->|"inhibits"| MITOPHAGY
HSPE1["HSPE1"]
TIMM22 -->|"inhibits"| HSPE1
OPA1["OPA1"]
TIMM22 -->|"inhibits"| OPA1
LAMP2["LAMP2"]
TIMM22 -->|"inhibits"| LAMP2
BNIP3L["BNIP3L"]
TIMM22 -->|"inhibits"| BNIP3L
MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
TIMM22 -->|"inhibits"| MITOCHONDRIAL_DYSFUNCTION
SIRT1["SIRT1"]
TIMM22 -->|"inhibits"| SIRT1
HTRA2["HTRA2"]
TIMM22 -->|"inhibits"| HTRA2
PARK2["PARK2"]
TIMM22 -->|"inhibits"| PARK2
PINK1["PINK1"]
TIMM22 -->|"inhibits"| PINK1
BNIP3["BNIP3"]
BNIP3 -->|"inhibits"| TIMM22
VDAC1["VDAC1"]
VDAC1 -->|"inhibits"| TIMM22
FUNDC1["FUNDC1"]
FUNDC1 -->|"inhibits"| TIMM22
TOMM20["TOMM20"]
TOMM20 -->|"inhibits"| TIMM22
TIMM9["TIMM9"]
TIMM9 -->|"inhibits"| TIMM22
TIMM17B["TIMM17B"]
TIMM17B -->|"inhibits"| TIMM22
OMA1["OMA1"]
OMA1 -->|"inhibits"| TIMM22
TIMM23["TIMM23"]
TIMM23 -->|"inhibits"| TIMM22
MTOR["MTOR"]
MTOR -->|"inhibits"| TIMM22
NRF1["NRF1"]
NRF1 -->|"inhibits"| TIMM22
HSPD1["HSPD1"]
HSPD1 -->|"inhibits"| TIMM22
MFN2["MFN2"]
MFN2 -->|"inhibits"| TIMM22
style TIMM22 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Heart Failure | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| HSPE1 | inhibits | gene | 0.60 |
| OPA1 | inhibits | gene | 0.60 |
| LAMP2 | inhibits | gene | 0.60 |
| BNIP3L | inhibits | gene | 0.60 |
| SIRT1 | inhibits | gene | 0.60 |
| HTRA2 | inhibits | gene | 0.60 |
| PARK2 | inhibits | gene | 0.60 |
| PINK1 | inhibits | gene | 0.60 |
| TIMM17A | inhibits | gene | 0.60 |
| EIF2A | inhibits | gene | 0.60 |
| TFAM | inhibits | gene | 0.60 |
| ULK1 | inhibits | gene | 0.60 |
| TIMM10 | inhibits | gene | 0.60 |
| DNM1L | inhibits | gene | 0.60 |
| MITOPHAGY | inhibits | gene | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | inhibits | gene | 0.60 |
| Unfolded Protein Response | inhibits | pathway | 0.60 |
| Mitophagy | inhibits | pathway | 0.60 |
| Mtor | inhibits | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BNIP3 | inhibits | gene | 0.60 |
| VDAC1 | inhibits | gene | 0.60 |
| FUNDC1 | inhibits | gene | 0.60 |
| TOMM20 | inhibits | gene | 0.60 |
| TIMM9 | inhibits | gene | 0.60 |
| TIMM17B | inhibits | gene | 0.60 |
| OMA1 | inhibits | gene | 0.60 |
| TIMM23 | inhibits | gene | 0.60 |
| MTOR | inhibits | gene | 0.60 |
| NRF1 | inhibits | gene | 0.60 |
| HSPD1 | inhibits | gene | 0.60 |
| MFN2 | inhibits | gene | 0.60 |
| MFF | inhibits | gene | 0.60 |
| BECN1 | inhibits | gene | 0.60 |
| LONP1 | inhibits | gene | 0.60 |
| CEBPB | inhibits | gene | 0.60 |
| SPG7 | inhibits | gene | 0.60 |
| MAP1LC3A | inhibits | gene | 0.60 |
| DDIT3 | inhibits | gene | 0.60 |
| JUN | inhibits | gene | 0.60 |
| TIMM50 | inhibits | gene | 0.60 |
| HSPA9 | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||