gene

MAP1LC3A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAP1LC3A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

493Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

MAP1LC3A is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, inhibits. Associated with ALS, Aging, Als. Connected to 306 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MAP1LC3A
Chromosome	20q11.22
Function	is a key structural component of the autophagosome, the double-membraned vesicle that engulfs cellular components for degradation and recycling [1].
Molecular Weight	14.5 kDa
Amino Acids	121 aa
Exons	7
Pathways	Akt, Wnt
GeneCards	MAP1LC3A
Human Protein Atlas	MAP1LC3A
Disease	MAP1LC3A/Autophagy Status
Frontotemporal Dementia	Impaired autophagy, TDP-43 aggregates colocalize with LC3[@kawabata2021]
Prion Disease	Autophagy required for prion protein clearance[@nixon2005]
Multiple System Atrophy	α-synuclein aggregates trigger autophagy dysfunction[@xilouri2016]
Vitamin D Deficiency	Reduced LC3 expression in substantia nigra
Dementia with Lewy Bodies	Impaired autophagic flux, LC3 accumulation
Associated Diseases	Aging, Cancer, Carcinoma, Cardiovascular, Hepatocellular Carcinoma, Ischemia
Known Drugs/Compounds	rapamycin
Interactions	MLKL, DEPTOR, HMGB1, EGF, MLST8, RICTOR
KG Connections	493 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MAP1LC3A["MAP1LC3A"] -->|"Interacts With"| Cancer["Cancer"]
    MAP1LC3A["MAP1LC3A"] -->|"Interacts With"| Als["Als"]
    MAP1LC3A["MAP1LC3A"] -->|"Interacts With"| Ms["Ms"]
    MAP1LC3A["MAP1LC3A"] -->|"Interacts With"| Fibrosis["Fibrosis"]
    MAP1LC3A["MAP1LC3A"] -->|"Associated With"| Ischemia["Ischemia"]
    MAP1LC3A["MAP1LC3A"] -->|"Inhibits"| Aging["Aging"]
    MAP1LC3A["MAP1LC3A"] -->|"Inhibits"| Cardiovascular["Cardiovascular"]
    MAP1LC3A["MAP1LC3A"] -->|"Associated With"| Carcinoma["Carcinoma"]
    OPTN["OPTN"] -->|"Interacts With"| MAP1LC3A["MAP1LC3A"]
    CASP3["CASP3"] -->|"Interacts With"| MAP1LC3A["MAP1LC3A"]
    AKT1["AKT1"] -->|"Interacts With"| MAP1LC3A["MAP1LC3A"]
    CALCOCO2["CALCOCO2"] -->|"Interacts With"| MAP1LC3A["MAP1LC3A"]
    CGAS["CGAS"] -->|"Interacts With"| MAP1LC3A["MAP1LC3A"]
    style MAP1LC3A fill:#8d4900,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Fibrosis fill:#b71c1c,color:#e0e0e0
    style Ischemia fill:#b71c1c,color:#e0e0e0
    style Aging fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Carcinoma fill:#b71c1c,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style CASP3 fill:#8d4900,color:#e0e0e0
    style AKT1 fill:#8d4900,color:#e0e0e0
    style CALCOCO2 fill:#8d4900,color:#e0e0e0
    style CGAS fill:#8d4900,color:#e0e0e0

Outgoing (288)

Target	Relation	Type	Str
SQSTM1	interacts_with	protein	0.95
Autophagy	associated_with	pathway	0.90
Tumor	associated_with	disease	0.75
MAP1LC3B	associated_with	gene	0.70
ATG7	associated_with	gene	0.70
TNF	associated_with	gene	0.70
Apoptosis	associated_with	pathway	0.70
APOPTOSIS	associated_with	gene	0.70
autophagy pathway	participates_in	pathway	0.70
Cancer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Fibrosis	interacts_with	disease	0.65
Ischemia	associated_with	disease	0.65
Aging	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Cardiovascular	inhibits	disease	0.65
Carcinoma	associated_with	disease	0.65
Als	regulates	disease	0.65
Fibrosis	regulates	disease	0.65
Aging	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Heart Failure	inhibits	disease	0.65
ALS	interacts_with	disease	0.65
Aging	degrades	disease	0.65
Cardiovascular	degrades	disease	0.65
Hepatocellular Carcinoma	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Lung Cancer	associated_with	disease	0.65
MAPK14	phosphorylates	entity	0.60
MAVS	phosphorylates	entity	0.60
MLKL	phosphorylates	entity	0.60
MLST8	phosphorylates	entity	0.60
MTOR	phosphorylates	entity	0.60
NBR1	phosphorylates	entity	0.60
OPTINEURIN	phosphorylates	entity	0.60
OPTN	phosphorylates	entity	0.60
P38	phosphorylates	entity	0.60
PI3K	phosphorylates	entity	0.60
PIK3C3	phosphorylates	entity	0.60
PPARG	phosphorylates	entity	0.60
RB1CC1	phosphorylates	entity	0.60
RHEB	phosphorylates	entity	0.60
RICTOR	phosphorylates	entity	0.60
RIPK1	phosphorylates	entity	0.60
RPS6KB1	phosphorylates	entity	0.60
RPTOR	phosphorylates	entity	0.60
SQSTM1	phosphorylates	entity	0.60
STAT3	phosphorylates	entity	0.60
STING1	phosphorylates	entity	0.60

Incoming (205)

Source	Relation	Type	Str
AUTOPHAGY	associated_with	gene	0.80
SQSTM1	associated_with	gene	0.70
BECN1	associated_with	gene	0.70
ATG14	associated_with	gene	0.70
LC3B	associated_with	gene	0.70
DDIT3	phosphorylates	entity	0.60
DEPTOR	phosphorylates	entity	0.60
EGF	phosphorylates	entity	0.60
EGFR	phosphorylates	entity	0.60
EIF2A	phosphorylates	entity	0.60
EIF2AK3	phosphorylates	entity	0.60
ERN1	phosphorylates	entity	0.60
FIP200	phosphorylates	entity	0.60
GABARAP	phosphorylates	entity	0.60
GRB2	phosphorylates	entity	0.60
HMGB1	phosphorylates	entity	0.60
HSP70	phosphorylates	entity	0.60
HSPA5	phosphorylates	entity	0.60
IFNG	phosphorylates	entity	0.60
JNK	phosphorylates	entity	0.60
LRRK2	phosphorylates	entity	0.60
ATG7	interacts_with	entity	0.60
BCL2L13	interacts_with	entity	0.60
BNIP3L	interacts_with	entity	0.60
COX4I1	interacts_with	entity	0.60
GAPDH	interacts_with	entity	0.60
CANCER	phosphorylates	entity	0.60
OPTN	interacts_with	gene	0.60
CASP3	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
CGAS	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
ATG16L1	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MAP1LC3A

Understanding Entity Pages

Summary

Wiki Pages (21)

MAP1LC3A Gene

FOXO1 Protein

ZFYVE26 Gene

lmx1b

Autophagy-Lysosomal Pathway in Parkinson's Disease

SPG15 Gene - Spastic Paraplegia 15

OPTN Protein (Optineurin)

mTOR Signaling in Autophagy and Lysosomal Function

Endosomal-Lysosomal Pathway in Neurodegeneration

Autophagy-Lysosome Pathway in Neurodegeneration

ATG10 Gene

Autophagy-Lysosomal Dysfunction in Neurodegenerative Diseases

FOXO3 Protein (Forkhead Box O3)

Autophagy Molecular Regulation in Neurodegeneration

Mitophagy Receptor Pathway in Neurodegeneration

GABARAP Protein

ATG5 — Autophagy Related 5

TOMM20 — Translocase of Outer Mitochondrial Membrane 20

PIK3C3 (VPS34) Protein