gene

MAP1LC3A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAP1LC3A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

493Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

MAP1LC3A is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, inhibits. Associated with ALS, Aging, Als. Connected to 306 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MAP1LC3A
Chromosome	20q11.22
Function	is a key structural component of the autophagosome, the double-membraned vesicle that engulfs cellular components for degradation and recycling [1].
Molecular Weight	14.5 kDa
Amino Acids	121 aa
Exons	7
Pathways	Akt, Wnt
GeneCards	MAP1LC3A
Human Protein Atlas	MAP1LC3A
Associated Diseases	Aging, Cancer, Carcinoma, Cardiovascular, Hepatocellular Carcinoma, Ischemia
Known Drugs/Compounds	rapamycin
Interactions	AKT1, AKT1S1, AMBRA1, AMPK, APC, ATF6
SciDEX Hypotheses	Autophagosome Marker Hijacking Strategy
KG Connections	493 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MAP1LC3A["MAP1LC3A"] -->|"Interacts With"| Cancer["Cancer"]
    MAP1LC3A["MAP1LC3A"] -->|"Interacts With"| Als["Als"]
    MAP1LC3A["MAP1LC3A"] -->|"Interacts With"| Ms["Ms"]
    MAP1LC3A["MAP1LC3A"] -->|"Interacts With"| Fibrosis["Fibrosis"]
    MAP1LC3A["MAP1LC3A"] -->|"Associated With"| Ischemia["Ischemia"]
    MAP1LC3A["MAP1LC3A"] -->|"Inhibits"| Aging["Aging"]
    MAP1LC3A["MAP1LC3A"] -->|"Inhibits"| Cardiovascular["Cardiovascular"]
    MAP1LC3A["MAP1LC3A"] -->|"Associated With"| Carcinoma["Carcinoma"]
    OPTN["OPTN"] -->|"Interacts With"| MAP1LC3A["MAP1LC3A"]
    CASP3["CASP3"] -->|"Interacts With"| MAP1LC3A["MAP1LC3A"]
    AKT1["AKT1"] -->|"Interacts With"| MAP1LC3A["MAP1LC3A"]
    CALCOCO2["CALCOCO2"] -->|"Interacts With"| MAP1LC3A["MAP1LC3A"]
    CGAS["CGAS"] -->|"Interacts With"| MAP1LC3A["MAP1LC3A"]
    style MAP1LC3A fill:#8d4900,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Fibrosis fill:#b71c1c,color:#e0e0e0
    style Ischemia fill:#b71c1c,color:#e0e0e0
    style Aging fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Carcinoma fill:#b71c1c,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style CASP3 fill:#8d4900,color:#e0e0e0
    style AKT1 fill:#8d4900,color:#e0e0e0
    style CALCOCO2 fill:#8d4900,color:#e0e0e0
    style CGAS fill:#8d4900,color:#e0e0e0

Outgoing (287)

Target	Relation	Type	Str
SQSTM1	interacts_with	protein	0.95
Autophagy	associated_with	pathway	0.90
Tumor	associated_with	disease	0.75
MAP1LC3B	associated_with	gene	0.70
APOPTOSIS	associated_with	gene	0.70
TNF	associated_with	gene	0.70
autophagy pathway	participates_in	pathway	0.70
Apoptosis	associated_with	pathway	0.70
ATG7	associated_with	gene	0.70
autophagy pathway	regulates	pathway	0.70
Lung Cancer	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
ALS	interacts_with	disease	0.65
Fibrosis	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ischemia	associated_with	disease	0.65
Aging	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Cancer	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Hepatocellular Carcinoma	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Cardiovascular	degrades	disease	0.65
Aging	degrades	disease	0.65
Heart Failure	inhibits	disease	0.65
Aging	associated_with	disease	0.65
Als	regulates	disease	0.65
Cardiovascular	inhibits	disease	0.65
Cardiovascular	associated_with	disease	0.65
Fibrosis	regulates	disease	0.65
Mtor	interacts_with	pathway	0.60
GAPDH	associated_with	gene	0.60
BCL2L13	associated_with	gene	0.60
Mitophagy	inhibits	pathway	0.60
Mitophagy	associated_with	pathway	0.60
Proteasome	associated_with	pathway	0.60
Toll-Like Receptor	associated_with	pathway	0.60
Phagocytosis	associated_with	pathway	0.60
UBIQUITIN	associated_with	gene	0.60
SIRT1	inhibits	gene	0.60
HTRA2	inhibits	gene	0.60
PARK2	inhibits	gene	0.60
PINK1	inhibits	gene	0.60
TIMM17A	inhibits	gene	0.60
EIF2A	inhibits	gene	0.60
TFAM	inhibits	gene	0.60
ULK1	inhibits	gene	0.60
TIMM10	inhibits	gene	0.60
DNM1L	inhibits	gene	0.60
FTH1	associated_with	gene	0.60

Incoming (206)

Source	Relation	Type	Str
AUTOPHAGY	associated_with	gene	0.80
LC3B	associated_with	gene	0.70
ATG14	associated_with	gene	0.70
MAPT	interacts_with	protein	0.70
SQSTM1	associated_with	gene	0.70
BECN1	associated_with	gene	0.70
AKT1	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
CGAS	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
ATG16L1	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
MAPK14	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
ATF6	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
HSP70	interacts_with	gene	0.60
TFE3	interacts_with	gene	0.60
PARKIN	associated_with	gene	0.60
BCL2L13	associated_with	gene	0.60
TOMM20	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
PARK2	associated_with	gene	0.60
BNIP3L	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
CEBPB	inhibits	gene	0.60
BNIP3	inhibits	gene	0.60
VDAC1	inhibits	gene	0.60
FUNDC1	inhibits	gene	0.60
TOMM20	inhibits	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
LC3B	interacts_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Autophagosome Marker Hijacking Strategy	0.000	-	How can ESCRT or SNARE targeting achieve

Mentioning Analyses (1)

Scientific analyses that reference this entity

How can ESCRT or SNARE targeting achieve tau-specific effects without disrupting

molecular biology | 2026-04-08 | 8 hypotheses Top: 0.380

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate identified fundamental druggability challenges for these targets due

closed · Rounds: 4 · Score: 0.95 · 2026-04-09

Related Research

Hypotheses and analyses mentioning MAP1LC3A in their description or question text

No additional research found