gene

MAP1LC3A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAP1LC3A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

493Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

MAP1LC3A is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, inhibits. Associated with ALS, Aging, Als. Connected to 306 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MAP1LC3A
Chromosome	20q11.22
Function	is a key structural component of the autophagosome, the double-membraned vesicle that engulfs cellular components for degradation and recycling [1].
Molecular Weight	14.5 kDa
Amino Acids	121 aa
Exons	7
Pathways	Akt, Wnt
GeneCards	MAP1LC3A
Human Protein Atlas	MAP1LC3A
Associated Diseases	Aging, Cancer, Carcinoma, Cardiovascular, Hepatocellular Carcinoma, Ischemia
Known Drugs/Compounds	rapamycin
Interactions	AKT1, AKT1S1, AMBRA1, AMPK, APC, ATF6
SciDEX Hypotheses	Autophagosome Marker Hijacking Strategy
KG Connections	493 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MAP1LC3A["MAP1LC3A"] -->|"Interacts With"| Cancer["Cancer"]
    MAP1LC3A["MAP1LC3A"] -->|"Interacts With"| Als["Als"]
    MAP1LC3A["MAP1LC3A"] -->|"Interacts With"| Ms["Ms"]
    MAP1LC3A["MAP1LC3A"] -->|"Interacts With"| Fibrosis["Fibrosis"]
    MAP1LC3A["MAP1LC3A"] -->|"Associated With"| Ischemia["Ischemia"]
    MAP1LC3A["MAP1LC3A"] -->|"Inhibits"| Aging["Aging"]
    MAP1LC3A["MAP1LC3A"] -->|"Inhibits"| Cardiovascular["Cardiovascular"]
    MAP1LC3A["MAP1LC3A"] -->|"Associated With"| Carcinoma["Carcinoma"]
    OPTN["OPTN"] -->|"Interacts With"| MAP1LC3A["MAP1LC3A"]
    CASP3["CASP3"] -->|"Interacts With"| MAP1LC3A["MAP1LC3A"]
    AKT1["AKT1"] -->|"Interacts With"| MAP1LC3A["MAP1LC3A"]
    CALCOCO2["CALCOCO2"] -->|"Interacts With"| MAP1LC3A["MAP1LC3A"]
    CGAS["CGAS"] -->|"Interacts With"| MAP1LC3A["MAP1LC3A"]
    style MAP1LC3A fill:#8d4900,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Fibrosis fill:#b71c1c,color:#e0e0e0
    style Ischemia fill:#b71c1c,color:#e0e0e0
    style Aging fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Carcinoma fill:#b71c1c,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style CASP3 fill:#8d4900,color:#e0e0e0
    style AKT1 fill:#8d4900,color:#e0e0e0
    style CALCOCO2 fill:#8d4900,color:#e0e0e0
    style CGAS fill:#8d4900,color:#e0e0e0

Outgoing (287)

Target	Relation	Type	Str
SQSTM1	interacts_with	protein	0.95
Autophagy	associated_with	pathway	0.90
Tumor	associated_with	disease	0.75
ATG7	associated_with	gene	0.70
Apoptosis	associated_with	pathway	0.70
TNF	associated_with	gene	0.70
APOPTOSIS	associated_with	gene	0.70
autophagy pathway	regulates	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
MAP1LC3B	associated_with	gene	0.70
Cardiovascular	inhibits	disease	0.65
Ischemia	associated_with	disease	0.65
Als	interacts_with	disease	0.65
Aging	degrades	disease	0.65
Cardiovascular	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Ms	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Als	regulates	disease	0.65
Cancer	interacts_with	disease	0.65
Hepatocellular Carcinoma	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Cardiovascular	degrades	disease	0.65
Fibrosis	interacts_with	disease	0.65
Fibrosis	regulates	disease	0.65
Lung Cancer	associated_with	disease	0.65
Heart Failure	inhibits	disease	0.65
ALS	interacts_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.60
P53	associated_with	gene	0.60
Unfolded Protein Response	inhibits	pathway	0.60
Mtor	inhibits	pathway	0.60
ATG	associated_with	gene	0.60
FERROPTOSIS	interacts_with	gene	0.60
COL1A1	associated_with	gene	0.60
FN1	associated_with	gene	0.60
Phagocytosis	associated_with	pathway	0.60
FBXW7	associated_with	gene	0.60
Toll-Like Receptor	associated_with	pathway	0.60
Epithelial-Mesenchymal Transition	associated_with	pathway	0.60
Ferroptosis	interacts_with	pathway	0.60
MITOPHAGY	inhibits	gene	0.60
APC	interacts_with	gene	0.60
BECN1	associated_with	gene	0.60
TP53	associated_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
DDIT3	inhibits	gene	0.60

Incoming (206)

Source	Relation	Type	Str
AUTOPHAGY	associated_with	gene	0.80
LC3B	associated_with	gene	0.70
SQSTM1	associated_with	gene	0.70
MAPT	interacts_with	protein	0.70
ATG14	associated_with	gene	0.70
BECN1	associated_with	gene	0.70
VDAC1	inhibits	gene	0.60
FUNDC1	inhibits	gene	0.60
TOMM20	inhibits	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
PRKN	associated_with	gene	0.60
ATG	associated_with	gene	0.60
FN1	associated_with	gene	0.60
ZFP36	associated_with	gene	0.60
BNIP3	inhibits	gene	0.60
CANCER	phosphorylates	entity	0.60
LC3B	interacts_with	gene	0.60
ATG5	associated_with	gene	0.60
FIP200	associated_with	gene	0.60
RB1	associated_with	gene	0.60
IFNG	associated_with	gene	0.60
LC3	associated_with	gene	0.60
DNA	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
AGING	degrades	gene	0.60
MITOPHAGY	degrades	gene	0.60
BRAIN INJURY	degrades	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
NIX	associated_with	gene	0.60
COL1A1	associated_with	gene	0.60
ROS	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
NADH	associated_with	gene	0.60
GENES	associated_with	gene	0.60
PHAGOCYTOSIS	associated_with	gene	0.60
CYP1A1	interacts_with	gene	0.60
GCN2	interacts_with	gene	0.60
GFP	interacts_with	gene	0.60
CEBPB	inhibits	gene	0.60
AKT1	interacts_with	gene	0.60
CGAS	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Autophagosome Marker Hijacking Strategy	0.000	-	How can ESCRT or SNARE targeting achieve

Mentioning Analyses (1)

Scientific analyses that reference this entity

How can ESCRT or SNARE targeting achieve tau-specific effects without disrupting

molecular biology | 2026-04-08 | 8 hypotheses Top: 0.380

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate identified fundamental druggability challenges for these targets due

closed · Rounds: 4 · Score: 0.95 · 2026-04-09

Related Research

Hypotheses and analyses mentioning MAP1LC3A in their description or question text

No additional research found