gene

TIMM17A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TIMM17A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections
0Hypotheses
0Analyses
10Outgoing
33Incoming

Summary

TIMM17A is a gene implicated in neurodegeneration research. Key relationships include: inhibits, implicated in. Associated with Heart Failure, Ms. Connected to 44 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolTIMM17A
Full NameTranslocase of Inner Mitochondrial Membrane 17A
AliasesTIM17A, TIM17, Pdr3p
Chromosome1q32.1
Functionis an essential component of the TIM22 translocase complex located in the mitochondrial inner membrane.
Primary Expressionneuronal tissues
Molecular Weight~17 kDa
Amino Acids171 aa
Exons6
Gene TypeProtein coding
UniProt IDO60830 (TIM17_HUMAN)
NCBI Gene ID10628
Ensembl IDENSG00000139360
GeneCardsTIMM17A
Human Protein AtlasTIMM17A
Associated Diseasesneurodegeneration
InteractionsEIF2A, TFAM, ULK1, TIMM10, DNM1L, BNIP3
KG Connections43 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: TIMM17A — AlphaFold O60830 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

timm17a

gene · 2702 words

TIMM23 — Translocase of Inner Mitochondrial Membrane 23

gene · 1951 words

TIMM21 — Translocase of Inner Mitochondrial Membrane 21

gene · 1855 words

TIMM17B — Translocase of Inner Mitochondrial Membrane 17B

gene · 1615 words

TIMM23 Protein — Translocase of Inner Mitochondrial Membrane 23

protein · 1329 words

TIMM22 Protein

protein · 636 words

Pathway Diagram

graph TD
    TIMM17A["<b>TIMM17A</b>"]
    Heart_Failure{"Heart Failure"}
    TIMM17A -->|"inhibits"| Heart_Failure
    Ms{"Ms"}
    TIMM17A -->|"inhibits"| Ms
    EIF2A["EIF2A"]
    TIMM17A -->|"inhibits"| EIF2A
    TFAM["TFAM"]
    TIMM17A -->|"inhibits"| TFAM
    ULK1["ULK1"]
    TIMM17A -->|"inhibits"| ULK1
    TIMM10["TIMM10"]
    TIMM17A -->|"inhibits"| TIMM10
    DNM1L["DNM1L"]
    TIMM17A -->|"inhibits"| DNM1L
    Unfolded_Protein_Response(["Unfolded Protein Response"])
    TIMM17A -->|"inhibits"| Unfolded_Protein_Response
    Mitophagy(["Mitophagy"])
    TIMM17A -->|"inhibits"| Mitophagy
    Mtor(["Mtor"])
    TIMM17A -->|"inhibits"| Mtor
    neurodegeneration["neurodegeneration"]
    TIMM17A -->|"implicated in"| neurodegeneration
    BNIP3["BNIP3"]
    BNIP3 -->|"inhibits"| TIMM17A
    VDAC1["VDAC1"]
    VDAC1 -->|"inhibits"| TIMM17A
    FUNDC1["FUNDC1"]
    FUNDC1 -->|"inhibits"| TIMM17A
    TOMM20["TOMM20"]
    TOMM20 -->|"inhibits"| TIMM17A
    TIMM9["TIMM9"]
    TIMM9 -->|"inhibits"| TIMM17A
    TIMM17B["TIMM17B"]
    TIMM17B -->|"inhibits"| TIMM17A
    OMA1["OMA1"]
    OMA1 -->|"inhibits"| TIMM17A
    TIMM23["TIMM23"]
    TIMM23 -->|"inhibits"| TIMM17A
    MTOR["MTOR"]
    MTOR -->|"inhibits"| TIMM17A
    NRF1["NRF1"]
    NRF1 -->|"inhibits"| TIMM17A
    HSPD1["HSPD1"]
    HSPD1 -->|"inhibits"| TIMM17A
    MFN2["MFN2"]
    MFN2 -->|"inhibits"| TIMM17A
    style TIMM17A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (10)

TargetRelationTypeStr
Heart Failureinhibitsdisease0.65
Msinhibitsdisease0.65
EIF2Ainhibitsgene0.60
TFAMinhibitsgene0.60
ULK1inhibitsgene0.60

Incoming (33)

SourceRelationTypeStr
BNIP3inhibitsgene0.60
VDAC1inhibitsgene0.60
FUNDC1inhibitsgene0.60
TOMM20inhibitsgene0.60
TIMM9inhibitsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found