Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TIMM17A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TIMM17A is a gene implicated in neurodegeneration research. Key relationships include: inhibits, implicated in. Associated with Heart Failure, Ms. Connected to 44 entities in the SciDEX knowledge graph.
| Gene Symbol | TIMM17A |
| Full Name | Translocase of Inner Mitochondrial Membrane 17A |
| Aliases | TIM17A, TIM17, Pdr3p |
| Chromosome | 1q32.1 |
| Function | is an essential component of the TIM22 translocase complex located in the mitochondrial inner membrane. |
| Primary Expression | neuronal tissues |
| Molecular Weight | ~17 kDa |
| Amino Acids | 171 aa |
| Exons | 6 |
| Gene Type | Protein coding |
| UniProt ID | O60830 (TIM17_HUMAN) |
| NCBI Gene ID | 10628 |
| Ensembl ID | ENSG00000139360 |
| GeneCards | TIMM17A |
| Human Protein Atlas | TIMM17A |
| Associated Diseases | neurodegeneration |
| Interactions | EIF2A, TFAM, ULK1, TIMM10, DNM1L, BNIP3 |
| KG Connections | 43 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
TIMM17A["<b>TIMM17A</b>"]
Heart_Failure{"Heart Failure"}
TIMM17A -->|"inhibits"| Heart_Failure
Ms{"Ms"}
TIMM17A -->|"inhibits"| Ms
EIF2A["EIF2A"]
TIMM17A -->|"inhibits"| EIF2A
TFAM["TFAM"]
TIMM17A -->|"inhibits"| TFAM
ULK1["ULK1"]
TIMM17A -->|"inhibits"| ULK1
TIMM10["TIMM10"]
TIMM17A -->|"inhibits"| TIMM10
DNM1L["DNM1L"]
TIMM17A -->|"inhibits"| DNM1L
Unfolded_Protein_Response(["Unfolded Protein Response"])
TIMM17A -->|"inhibits"| Unfolded_Protein_Response
Mitophagy(["Mitophagy"])
TIMM17A -->|"inhibits"| Mitophagy
Mtor(["Mtor"])
TIMM17A -->|"inhibits"| Mtor
neurodegeneration["neurodegeneration"]
TIMM17A -->|"implicated in"| neurodegeneration
BNIP3["BNIP3"]
BNIP3 -->|"inhibits"| TIMM17A
VDAC1["VDAC1"]
VDAC1 -->|"inhibits"| TIMM17A
FUNDC1["FUNDC1"]
FUNDC1 -->|"inhibits"| TIMM17A
TOMM20["TOMM20"]
TOMM20 -->|"inhibits"| TIMM17A
TIMM9["TIMM9"]
TIMM9 -->|"inhibits"| TIMM17A
TIMM17B["TIMM17B"]
TIMM17B -->|"inhibits"| TIMM17A
OMA1["OMA1"]
OMA1 -->|"inhibits"| TIMM17A
TIMM23["TIMM23"]
TIMM23 -->|"inhibits"| TIMM17A
MTOR["MTOR"]
MTOR -->|"inhibits"| TIMM17A
NRF1["NRF1"]
NRF1 -->|"inhibits"| TIMM17A
HSPD1["HSPD1"]
HSPD1 -->|"inhibits"| TIMM17A
MFN2["MFN2"]
MFN2 -->|"inhibits"| TIMM17A
style TIMM17A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Heart Failure | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| EIF2A | inhibits | gene | 0.60 |
| TFAM | inhibits | gene | 0.60 |
| ULK1 | inhibits | gene | 0.60 |
| TIMM10 | inhibits | gene | 0.60 |
| DNM1L | inhibits | gene | 0.60 |
| Unfolded Protein Response | inhibits | pathway | 0.60 |
| Mitophagy | inhibits | pathway | 0.60 |
| Mtor | inhibits | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BNIP3 | inhibits | gene | 0.60 |
| VDAC1 | inhibits | gene | 0.60 |
| FUNDC1 | inhibits | gene | 0.60 |
| TOMM20 | inhibits | gene | 0.60 |
| TIMM9 | inhibits | gene | 0.60 |
| TIMM17B | inhibits | gene | 0.60 |
| OMA1 | inhibits | gene | 0.60 |
| TIMM23 | inhibits | gene | 0.60 |
| MTOR | inhibits | gene | 0.60 |
| NRF1 | inhibits | gene | 0.60 |
| HSPD1 | inhibits | gene | 0.60 |
| MFN2 | inhibits | gene | 0.60 |
| MFF | inhibits | gene | 0.60 |
| BECN1 | inhibits | gene | 0.60 |
| LONP1 | inhibits | gene | 0.60 |
| CEBPB | inhibits | gene | 0.60 |
| SPG7 | inhibits | gene | 0.60 |
| MAP1LC3A | inhibits | gene | 0.60 |
| DDIT3 | inhibits | gene | 0.60 |
| JUN | inhibits | gene | 0.60 |
| TIMM50 | inhibits | gene | 0.60 |
| HSPA9 | inhibits | gene | 0.60 |
| TIMM22 | inhibits | gene | 0.60 |
| HSPE1 | inhibits | gene | 0.60 |
| OPA1 | inhibits | gene | 0.60 |
| LAMP2 | inhibits | gene | 0.60 |
| BNIP3L | inhibits | gene | 0.60 |
| SIRT1 | inhibits | gene | 0.60 |
| HTRA2 | inhibits | gene | 0.60 |
| PARK2 | inhibits | gene | 0.60 |
| PINK1 | inhibits | gene | 0.60 |
| MITOPHAGY | inhibits | gene | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||