gene

adora2a

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about adora2a: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

131Connections

0Hypotheses

0Analyses

1Outgoing

35Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	ADORA2A
Full Name	Adenosine A2a Receptor
Chromosome	22q11.23
Protein Family	GPCR
Target Class	Gpcr
Function	encodes a 412-amino acid protein primarily expressed in the striatum, olfactory tubercle, and nucleus accumbens.
Mechanism of Action	Small molecule antagonists blocking adenosine A2A receptor signaling
Primary Expression	the striatum, olfactory tubercle, and nucleus accumbens
Druggability	Medium (0.57)
Clinical Stage	Approved
Pathways	Apoptosis, Mitophagy, Oxidative Stress
GeneCards	ADORA2A
Human Protein Atlas	ADORA2A
Polymorphism	Location
1976C>T	3' UTR
Associated Diseases	ALZHEIMER, als, ms, neurodegeneration
Known Drugs/Compounds	Istradefylline, Preladenant, CHEMBL3989695, CHEMBL3694769, CHEMBL3942498, CHEMBL197669
Interactions	BNIP3L, BCL2, DRP1, DNM1L, BNIP3, C1Q
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Adenosine-Astrocyte Metabolic Reset
KG Connections	129 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🧬 3D Structure: adora2a — PDB 4EIY Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ADORA2A["ADORA2A"]
    ADORA2A -->|"regulates"| ALS["ALS"]
    ADORA2A -->|"interacts"| Alzheimer["Alzheimer"]
    ADORA2A -->|"regulates"| Aging["Aging"]
    ADORA2A -->|"implicated in"| neurodegeneration["neurodegeneration"]
    ADORA2A -->|"interacts"| BNIP3L["BNIP3L"]
    ADORA2A -->|"regulates"| Mitophagy["Mitophagy"]
    ADORA2A -->|"regulates"| Apoptosis["Apoptosis"]
    ADORA2A -->|"interacts"| Autophagy["Autophagy"]
    ADORA2A -->|"regulates"| Oxidative_Stress["Oxidative Stress"]
    ADORA2A -->|"interacts"| BCL2["BCL2"]
    h_41bc2d38["h-41bc2d38"] -->|"target for"| ADORA2A
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"regulates"| ADORA2A
    AMBRA1["AMBRA1"] -->|"interacts"| ADORA2A
    DRP1["DRP1"] -->|"interacts"| ADORA2A
    APOPTOSIS["APOPTOSIS"] -->|"regulates"| ADORA2A
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| ADORA2A
    BNIP3["BNIP3"] -->|"interacts"| ADORA2A
    MITOPHAGY["MITOPHAGY"] -->|"regulates"| ADORA2A

Outgoing (96)

Target	Relation	Type	Str
neurodegeneration	implicated_in	disease	0.50

Incoming (35)

Source	Relation	Type	Str
adenosine	activates	compound	0.90
h-41bc2d38	targets_gene	hypothesis	0.90
h-41bc2d38	targets	hypothesis	0.80
AMBRA1	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
BNIP3	interacts_with	gene	0.60
OVERVIEW	regulates	gene	0.60
BCL2	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
BNIP3L	interacts_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
MITOPHAGY	regulates	gene	0.60
NIX	interacts_with	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
AGING	regulates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
RNA	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
BMAL1	co_discussed	gene	0.40
HCRTR2	co_discussed	gene	0.40
CLOCK	co_discussed	gene	0.40
BDNF	co_discussed	gene	0.40
AQP4	co_discussed	gene	0.40
MTNR1A	co_discussed	gene	0.40
CX3CR1	co_discussed	gene	0.40
HCRT	co_discussed	gene	0.40
CACNA1G	co_discussed	gene	0.40
ADRA2A	co_discussed	gene	0.40
TFEB	co_discussed	gene	0.40
A2A Adenosine Receptor Protein	references	protein	0.40
HDAC	co_discussed	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

adora2a

Understanding Entity Pages

Wiki Pages (21)

ADORA2A Gene

Section 99: Purinergic Signaling and P2X/P2Y Receptors in CBS/PSP

ADCY3 — Adenylate Cyclase 3

IL27 — Interleukin 27

Autophagy Enhancement for Tauopathy

Adenosine Signaling in Neurodegeneration

Purinergic Signaling in Parkinson's Disease

Striatal Medium Spiny Neurons in Neurodegenerative Disease

G-Protein Coupled Receptor Signaling in Parkinson's Disease

Autophagy Enhancers for PD

Purinergic Signaling Dysfunction Hypothesis in Parkinson's Disease

Adenosine A2A Receptor Antagonist Therapy

ADCY5 Gene

Adenosine A2A Receptor Neurons

Adenosine A1/A3 Receptor Modulator Therapy

Istradefylline (Nourianz)

Microglia Modulation Therapies

G Proteins

GNAL — Gαolf Subunit