gene

CRH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CRH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

647Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

CRH is a gene implicated in neurodegeneration research. Key relationships include: activates, expressed in, associated with. Associated with ALI, ALS, ALZHEIMER. Connected to 189 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CRH
Chromosome	8q13
Protein Type	Ligand
Target Class	Ligand
Function	The CRH gene encodes prepro-CRH, a precursor peptide that is processed to mature CRH.
Mechanism of Action	CRH receptor antagonist blocking stress hormone signaling
Primary Expression	brain regions involved in stress and emotion:
Druggability	Low (0.34)
Clinical Stage	Approved
Amino Acids	41 aa
Pathways	Apoptosis, Blood-Brain Barrier, Complement, HPA-axis, HPA_AXIS
UniProt ID	P06850
Ensembl ID	ENSG00000118271
GeneCards	CRH
Human Protein Atlas	CRH
Associated Diseases	Addiction, Alopecia Areata, Als, Alzheimer, Cancer
Known Drugs/Compounds	dexamethasone
Interactions	ACTH, Actin, AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID
SciDEX Target	View Target Profile (10 clinical trials)
KG Connections	645 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CRH — AlphaFold P06850 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (15)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CRH["CRH"] -->|"associated"| neurodegeneration["neurodegeneration"]
    CRH["CRH"] -->|"interacts"| NR3C1["NR3C1"]
    CRH["CRH"] -->|"interacts"| TNFA["TNFA"]
    CRH["CRH"] -->|"co discussed"| BDNF["BDNF"]
    CRH["CRH"] -->|"co discussed"| ULK1["ULK1"]
    CRH["CRH"] -->|"co discussed"| SNCA["SNCA"]
    NR3C1_1["NR3C1"] -->|"interacts"| CRH["CRH"]
    TNFA_2["TNFA"] -->|"interacts"| CRH["CRH"]
    BMAL1["BMAL1"] -->|"co discussed"| CRH["CRH"]
    CLOCK["CLOCK"] -->|"co discussed"| CRH["CRH"]
    style CRH fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (483)

Target	Relation	Type	Str
ACTH	activates	protein	1.00
Central Amygdala	expressed_in	cell_type	0.95
HPA-axis	regulates	pathway	0.95
ACTH	stimulates	protein	0.90
Hypothalamic-Pituitary-Adrenal Axis	component_of	pathway	0.90
Hpa Axis	involved_in	pathway	0.90
Stress-Induced Hyperglycemia	mediates	phenotype	0.90
thalamus	expressed_in	brain_region	0.90
hypothalamus	expressed_in	brain_region	0.90
CRHR1	activates	protein	0.87
HPA_AXIS	participates_in	pathway	0.87
Alopecia Areata	associated_with	disease	0.85
Alopecia Areata	upregulates	disease	0.85
Alcohol Intake	modulates	phenotype	0.85
Paraventricular Nucleus	expressed_in	cell_type	0.85
Post-Traumatic Stress Disorder	associated_with	disease	0.85
HPA Axis Homeostasis	regulates	process	0.80
neurons	releases	cell_type	0.80
NR3C1	co_mentioned_with	gene	0.80
Hypersexual Disorder	associated_with	disease	0.80
CeA	expressed_in	brain_region	0.80
neurons	activates	cell_type	0.80
oxidative stress response	participates_in	pathway	0.80
stress_response	activates	pathway	0.80
HPA_AXIS	regulates	pathway	0.76
Post-Traumatic Stress Disorder	involved_in	disease	0.75
PVN	expressed_in	brain_region	0.72
GUT_DYSBIOSIS	causes	phenotype	0.72
APIR	expressed_in	brain_region	0.72
neuroinflammation	activates	disease	0.70
Hypersexual Disorder	biomarker_for	disease	0.70
serotonin	releases	neurotransmitter	0.70
mast cells	activates	cell_type	0.70
neurons	implicated_in	cell_type	0.70
mast cells	regulates	cell_type	0.70
amygdala	expressed_in	brain_region	0.70
depression	associated_with	disease	0.70
depression	implicated_in	disease	0.70
unfolded protein response	participates_in	pathway	0.70
neurons	regulates	cell_type	0.70
cortex	expressed_in	brain_region	0.70
SOCIAL_MOTIVATION	activates	phenotype	0.68
BMA	activates	brain_region	0.68
SOCIAL_INTERACTION	inhibits	phenotype	0.68
Alzheimer	expressed_in	disease	0.65
Neuroinflammation	activates	disease	0.65
Ms	inhibits	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Depression	contributes_to	disease	0.65
Als	contributes_to	disease	0.65

Incoming (164)

Source	Relation	Type	Str
h-1e564178	targets_gene	hypothesis	0.90
Stress	upregulates	process	0.90
PVN	produces	brain_region	0.87
Familiar Context Stress	upregulates	process	0.85
DNA Methylation	regulates	mechanism	0.85
h-1e564178	targets	hypothesis	0.80
STRESS	activates	phenotype	0.72
AVP	interacts_with	gene	0.70
OLFACTORY_CUES	activates	phenotype	0.64
ALZHEIMER	activates	disease	0.64
TNFA	interacts_with	gene	0.61
NR3C1	interacts_with	gene	0.61
BDNF	co_mentioned_with	gene	0.60
NR3C1	inhibits	gene	0.60
BDNF	regulates	gene	0.60
CALCA	inhibits	gene	0.60
BDNF	activates	gene	0.60
AND	causes	gene	0.60
WNT	activates	gene	0.60
RNA	associated_with	gene	0.60
CRHR1	inhibits	gene	0.60
BDNF	associated_with	gene	0.60
KMT2A	inhibits	gene	0.60
CD8	associated_with	gene	0.60
APP	phosphorylates	gene	0.60
APP	activates	gene	0.60
AVP	binds_to	gene	0.60
RAS	activates	gene	0.60
INSULIN RESISTANCE	activates	gene	0.60
CYTOKINES	activates	gene	0.60
IL-6	activates	gene	0.60
DIABETES MELLITUS	activates	gene	0.60
CYTOKINES	interacts_with	gene	0.60
AUTOPHAGY	activates	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
DEPRESSION	contributes_to	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
ANXIETY	regulates	gene	0.60
AMYLOID	activates	gene	0.60
AMYLOID	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
MICROGLIA	activates	gene	0.60
CREB	protects_against	gene	0.60
ASTROCYTE	activates	gene	0.60
AND	associated_with	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
PARKINSON	activates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Digital biomarkers and AI-driven early detection of neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.759

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Can speech, gait, retinal imaging, sleep, and smartphone data detect neurodegene

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

CRH

Understanding Entity Pages

Summary

Wiki Pages (15)

Edinger-Westphal Nucleus in Pupillary Reflex

CRH-Positive Hippocampal Neurons

Hypothalamic CRH Neurons

Corticotropin Releasing Hormone (CRH)

Amygdala CRH Neurons

Paraventricular Hypothalamic CRH Neurons

Corticotropin-Releasing Hormone (CRH) Neurons

Hypothalamic CRH Neurons in Stress-Related Disorders

CRH Gene

CRHR1

Paraventricular Nucleus CRH Neurons

CRH Neurons