concept

GPX4/SLC7A11

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GPX4/SLC7A11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

163Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

8Experiments

Summary

GPX4/SLC7A11 is a concept in neurodegeneration research. Key relationships include: regulates, activates, inhibits. Associated with ALS, Autoimmune, Carcinoma. Connected to 49 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	GPX4/SLC7A11
Related Diseases	Autoimmune, ALS, Fibrosis, Carcinoma, Ischemia

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    GPX4_SLC7A11["<b>GPX4/SLC7A11</b>"]
    GPX4_SLC7A11 -->|"regulates"| Autoimmune["Autoimmune"]
    GPX4_SLC7A11 -->|"regulates"| ALS["ALS"]
    GPX4_SLC7A11 -->|"regulates"| Fibrosis["Fibrosis"]
    GPX4_SLC7A11 -->|"regulates"| Carcinoma["Carcinoma"]
    GPX4_SLC7A11 -->|"activates"| Ischemia["Ischemia"]
    GPX4_SLC7A11 -->|"regulates"| NRF2["NRF2"]
    GPX4_SLC7A11 -->|"regulates"| ACSL4["ACSL4"]
    GPX4_SLC7A11 -->|"regulates"| FERROPTOSIS["FERROPTOSIS"]
    GPX4_SLC7A11 -->|"regulates"| PYROPTOSIS["PYROPTOSIS"]
    GPX4_SLC7A11 -->|"regulates"| Ferroptosis["Ferroptosis"]
    GPX4_SLC7A11 -->|"regulates"| Pyroptosis["Pyroptosis"]
    GPX4_SLC7A11 -->|"activates"| SIRT3["SIRT3"]
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"regulates"| GPX4_SLC7A11
    HO_1["HO-1"] -->|"regulates"| GPX4_SLC7A11
    NATURAL_COMPOUNDS["NATURAL COMPOUNDS"] -->|"regulates"| GPX4_SLC7A11
    GENES["GENES"] -->|"regulates"| GPX4_SLC7A11
    GPX4["GPX4"] -->|"activates"| GPX4_SLC7A11
    ACETYL_COA["ACETYL-COA"] -->|"inhibits"| GPX4_SLC7A11
    NCOA4["NCOA4"] -->|"inhibits"| GPX4_SLC7A11
    NRF2 -->|"regulates"| GPX4_SLC7A11
    AND["AND"] -->|"regulates"| GPX4_SLC7A11
    PYROPTOSIS -->|"regulates"| GPX4_SLC7A11
    FERROPTOSIS -->|"regulates"| GPX4_SLC7A11

Outgoing (98)

Target	Relation	Type	Str
Autoimmune	regulates	disease	0.65
ALS	regulates	disease	0.65
Fibrosis	regulates	disease	0.65
Carcinoma	regulates	disease	0.65
Ischemia	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Autoimmune	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Cancer	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
NCOA4	expressed_in	entity	0.60
SLC7A11	expressed_in	entity	0.60
NRF2	regulates	gene	0.60
ACSL4	regulates	gene	0.60
SLC7A11	associated_with	gene	0.60
SIRT3	activates	gene	0.60
NRF2	activates	gene	0.60
SLC7A11	activates	gene	0.60
SLC7A11	inhibits	gene	0.60
GPX4	activates	gene	0.60
GPX4	inhibits	gene	0.60
NCOA4	inhibits	gene	0.60
ESR1	therapeutic_target	gene	0.60
MTOR	activates	gene	0.60
PIK3CA	therapeutic_target	gene	0.60
MAPK1	therapeutic_target	gene	0.60
ACSL4	therapeutic_target	gene	0.60
PPAR	therapeutic_target	gene	0.60
MAPK1	expressed_in	gene	0.60
HSP90AA1	expressed_in	gene	0.60
PI3K	activates	gene	0.60
ESR1	expressed_in	gene	0.60
GPX4	associated_with	gene	0.60
Podocyte	therapeutic_target	cell_type	0.60
Ferritin	regulates	protein	0.60
Rb	inhibits	protein	0.60
FERROPTOSIS	regulates	gene	0.60
PYROPTOSIS	regulates	gene	0.60
Ferroptosis	regulates	pathway	0.60
Pyroptosis	regulates	pathway	0.60
FERROPTOSIS	activates	gene	0.60
Ferroptosis	activates	pathway	0.60
FERROPTOSIS	inhibits	gene	0.60
AUTOPHAGY	regulates	gene	0.60
Ferroptosis	inhibits	pathway	0.60

Incoming (65)

Source	Relation	Type	Str
GPX4	expressed_in	entity	0.60
GPX4	associated_with	gene	0.60
GPX4	activates	gene	0.60
NCOA4	inhibits	gene	0.60
GPX4	inhibits	gene	0.60
SLC7A11	associated_with	gene	0.60
NRF2	regulates	gene	0.60
ACSL4	regulates	gene	0.60
SLC7A11	activates	gene	0.60
NRF2	activates	gene	0.60
SIRT3	activates	gene	0.60
SLC7A11	inhibits	gene	0.60
NRF2	therapeutic_target	gene	0.60
ACSL4	therapeutic_target	gene	0.60
AKT	activates	gene	0.60
PI3K	activates	gene	0.60
HSP90AA1	therapeutic_target	gene	0.60
PIK3CA	expressed_in	gene	0.60
MTOR	activates	gene	0.60
PPAR	therapeutic_target	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
HO-1	regulates	gene	0.60
NATURAL COMPOUNDS	regulates	gene	0.60
GENES	regulates	gene	0.60
ACETYL-COA	inhibits	gene	0.60
PYROPTOSIS	regulates	gene	0.60
FERROPTOSIS	regulates	gene	0.60
FERROPTOSIS	activates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
GENES	therapeutic_target	gene	0.60
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	0.60
NATURAL COMPOUNDS	therapeutic_target	gene	0.60
MAO	regulates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
P53	activates	gene	0.60
AND	regulates	gene	0.60
AND	activates	gene	0.60
GSH	activates	gene	0.60
RNA	regulates	gene	0.60
AND	inhibits	gene	0.60
PYROPTOSIS	therapeutic_target	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
ROS	expressed_in	gene	0.60
HO-1	therapeutic_target	gene	0.60
FERROPTOSIS	therapeutic_target	gene	0.60
ferroptosis	inhibits	phenotype	0.50
SLC7A11	regulates	gene	0.50
GPX4	regulates	gene	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Senescence-Induced Lipid Peroxidation Spreading	0.533	neurodegeneration	Senolytic therapy for age-related neurod

Mentioning Analyses (1)

Scientific analyses that reference this entity

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.703

Experiments (8)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Iron Dyshomeostasis in MSA Pathogenesis Experiment	validation	Neurodegeneration	0.400	0.50	human	proposed	$2,280,000
Traumatic Brain Injury and Alzheimer's Disease Relationship	validation	Alzheimer's Disease	0.400	0.50	human	proposed	$3,000,000
Peroxisomal Dysfunction Validation in Parkinson's Disease	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,280,000
Peroxisome Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Regulated Necrosis Validation Study in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Ferroptosis Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Biomechanical Impact Profiles and Chronic Traumatic Encephalopathy Phe	clinical	Neurodegeneration	0.400	0.50	in_silico	proposed	$180,000
Proposed experiment from debate on Senolytics targeting p16/p21+ senes	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000

Related Papers (18)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Klebsiella pneumoniae Induces Ferroptosis and Lactation Dysfunction in Bovine Ma [PMID:40937759]	Mao P, Wang Z, Duan J, Dong P, Yuan C, L	J Agric Food Chem	2025	1
Targeting ferroptosis: novel therapeutic approaches and intervention strategies [PMID:41425591]	Luo Y, Long M, Wu X, Zeng L	Front Immunol	2025	1
Trimetazidine attenuates Ischemia/Reperfusion-Induced myocardial ferroptosis by [PMID:39134283]	Tan M, Yin Y, Chen W, Zhang J, Jin Y, Zh	Biochem Pharmacol	2024	1
Discovery of a glycosylated colchicine derivative as a neuroprotective agent for [PMID:41455281]	["Jash M", "Gupta S", "Garg S", "Khan J"	European journal of medicinal	2026	0
The NADPH oxidase inhibitor Vas2870 prevents myocyte ferroptosis and improves ca [PMID:41671579]	Wang J, Li CM, Yang B, Tantai RN, Guo HX	British journal of pharmacolog	2026	0
From association to mechanism: Prenatal PFAS Co-exposures induces fetal neural t [PMID:41485332]	Chen Y, Cheng Q, Yang C, Li S, Lin H, Li	Journal of hazardous materials	2026	0
Silencing myeloid cell leukemia-1 improves apoptotic and ferroptotic responses i [PMID:41540498]	Fang F, Xu Q, Shen S, Wang S, Bao C	European journal of medical re	2026	0
Traditional Chinese Herbal Formula XuMingZhuSan Alleviates Neuronal Ferroptosis [PMID:41822239]	Liu X, Wang C, Han L, Xiao Y, Yu H, Hu Z	Food science & nutrition	2026	0
Psoraleae Fructus combined with Walnut kernels improves postmenopausal osteoporo [PMID:41016294]	["Hu L", "Luo M", "Zhu X", "Wang Z", "Ya	Phytomedicine : international	2025	0
Polystyrene microplastics induced spermatogenesis disorder via disrupting mitoch [PMID:39577614]	["Jin H", "Xue B", "Chen X", "Ma T", "Ma	Environmental pollution (Barki	2025	0
Yi-Nao-Jie-Yu Prescription Relieves Post-Stroke Depression by Mitigating Ferropt [PMID:40214929]	["Zhang Y", "Tang Q", "Yao J", "Liu H",	Journal of neuroimmune pharmac	2025	0
Light-triggered carbon monoxide-induced activation of enhanced ferritinophagy-me [PMID:41080723]	["Liu Q", "Zhang J", "Yu L", "Chen Y", "	Materials today. Bio	2025	0
Triptolide induces hepatotoxicity by promoting ferroptosis through Nrf2 degradat [PMID:39503881]	["Guo L", "Yang Y", "Ma J", "Xiao M", "C	Cell biology and toxicology	2024	0
Mifepristone protects acetaminophen induced liver injury through NRF2/GSH/GST me [PMID:38906233]	["Shi Y", "Xu N", "Liu B", "Ma Y", "Fu X	Free radical biology & medicin	2024	0
Use of Deep-Learning Assisted Assessment of Cardiac Parameters in Zebrafish to D [PMID:37679058]	["Liu C", "Wang Y", "Zeng Y", "Kang Z",	Advanced science (Weinheim, Ba	2023	0
In Vivo Assessment of Ferroptosis and Ferroptotic Stress in Mice. [PMID:35384401]	["Ide K", "Souma T"]	Current protocols	2022	0
En masse DNA Electroporation for in vivo Transcriptional Assay in Ascidian Embry [PMID:34692910]	Darras S	Bio-protocol	2021	0
Management of primary aldosteronism and mineralocorticoid receptor-associated hy [PMID:32424201]	["Morimoto S", "Ichihara A"]	Hypertension research : offici	2020	0

GPX4/SLC7A11

Understanding Entity Pages

Summary

Wiki Pages (20)

Ferroptosis in Alzheimer's Disease

Cellular Senescence in Neurodegeneration

Ferroptosis in Neurodegeneration

Ferroptotic Neurons

ALS Regional Onset and Spread: Network-Level Staging Model

Ferroptosis

Section 191: Advanced Lipid Signaling Modulators in CBS/PSP

Ferroptosis Therapy for Parkinson's Disease

Levodopa-Induced Dyskinesia Management — MDS 2026

Iron Dyshomeostasis in MSA Pathogenesis Experiment

Ferroptosis Modulation Therapy

nadph-oxidase-inhibitors

Age-Sensitive Cortical Vulnerability in Parkinson's Disease

GPX4 (Glutathione Peroxidase 4)

Cellular Reprogramming and Neuronal Replacement Therapies

SLC7A11 Gene - xCT Cystine/Glutamate Antiporter

GPX4 Protein - Glutathione Peroxidase 4

GPX4 Gene - Glutathione Peroxidase 4

REL Gene

xCT Protein - SLC7A11 Cystine/Glutamate Antiporter