CASPASE3

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASPASE3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

CASPASE3 is a protein involved in neurodegeneration research. Key relationships include: associated with, inhibits, regulates. Associated with ALS, Aging, Cancer. Connected to 27 entities in the SciDEX knowledge graph.

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graph TD
    CASPASE3["<b>CASPASE3</b>"]
    APOPTOSIS["APOPTOSIS"]
    CASPASE3 -->|"regulates"| APOPTOSIS
    Lymphoma{"Lymphoma"}
    CASPASE3 -->|"associated with"| Lymphoma
    Aging{"Aging"}
    CASPASE3 -->|"inhibits"| Aging
    Heart_Failure{"Heart Failure"}
    CASPASE3 -->|"inhibits"| Heart_Failure
    Cancer{"Cancer"}
    CASPASE3 -->|"inhibits"| Cancer
    ALS{"ALS"}
    CASPASE3 -->|"inhibits"| ALS
    BAX["BAX"]
    CASPASE3 -->|"associated with"| BAX
    JUN["JUN"]
    CASPASE3 -->|"inhibits"| JUN
    CASPASE8["CASPASE8"]
    CASPASE3 -->|"associated with"| CASPASE8
    BCL2["BCL2"]
    CASPASE3 -->|"associated with"| BCL2
    CANCER["CANCER"]
    CASPASE3 -->|"inhibits"| CANCER
    FOXO1["FOXO1"]
    CASPASE3 -->|"associated with"| FOXO1
    CASP3["CASP3"]
    CASP3 -->|"encodes"| CASPASE3
    NFKB["NFKB"]
    NFKB -->|"activates"| CASPASE3
    EHMT2["EHMT2"]
    EHMT2 -->|"associated with"| CASPASE3
    APOPTOSIS -->|"inhibits"| CASPASE3
    BCL_2["BCL-2"]
    BCL_2 -->|"associated with"| CASPASE3
    AND["AND"]
    AND -->|"associated with"| CASPASE3
    CASPASE8 -->|"associated with"| CASPASE3
    BAX -->|"associated with"| CASPASE3
    JUN -->|"inhibits"| CASPASE3
    BCL2 -->|"associated with"| CASPASE3
    FOXO1 -->|"associated with"| CASPASE3
    CANCER -->|"inhibits"| CASPASE3
    style CASPASE3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0