Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EXOSOMES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
EXOSOMES is a concept in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with ALS, Aging, Als. Connected to 578 entities in the SciDEX knowledge graph.
| Name | EXOSOMES |
| Summary | Page for Engineered Exosomes for Intranasal CNS Delivery |
| Key Genes/Proteins | CANCER |
| Related Diseases | Inflammation, Als, Neuroinflammation, Tumor, Cancer |
| Related Pathways | Blood-Brain Barrier, Apoptosis |
Knowledge base pages for this entity
flowchart TD
EXOSOMES(["EXOSOMES"])
Inflammation["Inflammation"]
Blood_Brain_Barrier["Blood-Brain Barrier"]
Als["Als"]
Neuroinflammation["Neuroinflammation"]
Tumor["Tumor"]
Cancer["Cancer"]
Aging["Aging"]
INFLAMMATION(["INFLAMMATION"])
MIRNAS(["MIRNAS"])
CANCER(["CANCER"])
Apoptosis["Apoptosis"]
APOPTOSIS(["APOPTOSIS"])
EXOSOMES -->|"activates"| Inflammation
EXOSOMES -->|"therapeutic target"| Inflammation
EXOSOMES -->|"therapeutic target"| Blood_Brain_Barrier
EXOSOMES -->|"therapeutic target"| Als
EXOSOMES -->|"therapeutic target"| Neuroinflammation
EXOSOMES -->|"therapeutic target"| Tumor
EXOSOMES -->|"therapeutic target"| Cancer
EXOSOMES -->|"therapeutic target"| Aging
EXOSOMES -->|"biomarker for"| Als
INFLAMMATION -->|"therapeutic target"| EXOSOMES
MIRNAS -->|"therapeutic target"| EXOSOMES
INFLAMMATION -->|"activates"| EXOSOMES
CANCER -->|"therapeutic target"| EXOSOMES
EXOSOMES -->|"therapeutic target"| Apoptosis
APOPTOSIS -->|"therapeutic target"| EXOSOMES
style EXOSOMES fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Inflammation | activates | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Blood-Brain Barrier | therapeutic_target | pathway | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Neuroinflammation | therapeutic_target | disease | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Aging | therapeutic_target | disease | 1.00 |
| Als | biomarker_for | disease | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| Aging | activates | disease | 0.95 |
| Alzheimer | therapeutic_target | disease | 0.95 |
| Parkinson | therapeutic_target | disease | 0.95 |
| Ischemia | activates | disease | 0.95 |
| Oxidative Stress | therapeutic_target | pathway | 0.90 |
| Stem Cell | therapeutic_target | pathway | 0.90 |
| Microrna | therapeutic_target | pathway | 0.90 |
| Als | regulates | disease | 0.85 |
| Diabetes | regulates | disease | 0.85 |
| Als | activates | disease | 0.85 |
| Fibrosis | activates | disease | 0.85 |
| Stroke | therapeutic_target | disease | 0.85 |
| Als | inhibits | disease | 0.85 |
| Cancer | biomarker_for | disease | 0.85 |
| CANCER | associated_with | gene | 0.80 |
| Apoptosis | inhibits | pathway | 0.80 |
| Exocytosis | activates | pathway | 0.80 |
| Nf-Κb | activates | pathway | 0.80 |
| Stem Cell | activates | pathway | 0.80 |
| Mitophagy | activates | pathway | 0.80 |
| Drug Resistance | therapeutic_target | pathway | 0.80 |
| Differentiation | activates | pathway | 0.80 |
| Tumor | activates | disease | 0.75 |
| Cardiovascular | associated_with | disease | 0.75 |
| Cancer | activates | disease | 0.75 |
| Aging | biomarker_for | disease | 0.75 |
| Traumatic Brain Injury | therapeutic_target | disease | 0.75 |
| Neurodegeneration | therapeutic_target | disease | 0.75 |
| Multiple Sclerosis | therapeutic_target | disease | 0.75 |
| Ischemia | therapeutic_target | disease | 0.75 |
| Obesity | activates | disease | 0.75 |
| Tumor | regulates | disease | 0.75 |
| Tumor | associated_with | disease | 0.75 |
| Carcinoma | activates | disease | 0.75 |
| Cancer | associated_with | disease | 0.75 |
| Cardiovascular | activates | disease | 0.75 |
| Alzheimer | biomarker_for | disease | 0.75 |
| Myocardial Infarction | activates | disease | 0.75 |
| Cardiac | activates | disease | 0.75 |
| Epilepsy | therapeutic_target | disease | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| MIRNAS | therapeutic_target | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | therapeutic_target | gene | 0.90 |
| OXIDATIVE STRESS | therapeutic_target | gene | 0.90 |
| NEUROINFLAMMATION | therapeutic_target | gene | 0.90 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 0.80 |
| PARKINSON'S DISEASE | therapeutic_target | gene | 0.80 |
| AKT | activates | gene | 0.80 |
| MIRNAS | associated_with | gene | 0.80 |
| NF-ΚB | activates | gene | 0.80 |
| STROKE | therapeutic_target | gene | 0.80 |
| MICRORNAS | therapeutic_target | gene | 0.80 |
| AGING | therapeutic_target | gene | 0.80 |
| APOPTOSIS | inhibits | gene | 0.80 |
| MITOPHAGY | activates | gene | 0.80 |
| PARKIN | activates | gene | 0.80 |
| DNA | therapeutic_target | gene | 0.80 |
| MIRNAS | activates | gene | 0.80 |
| CANCER | biomarker_for | gene | 0.80 |
| NEURODEGENERATION | therapeutic_target | gene | 0.70 |
| JUN | activates | gene | 0.70 |
| ROS | inhibits | gene | 0.70 |
| CANCER | activates | gene | 0.70 |
| AMPK | activates | gene | 0.70 |
| PARKINSON | therapeutic_target | gene | 0.70 |
| PI3K | therapeutic_target | gene | 0.70 |
| AKT | therapeutic_target | gene | 0.70 |
| PI3K | activates | gene | 0.70 |
| NEURODEGENERATIVE DISORDERS | therapeutic_target | gene | 0.70 |
| EPILEPSY | therapeutic_target | gene | 0.70 |
| ALZHEIMER | therapeutic_target | gene | 0.70 |
| OVERVIEW | therapeutic_target | gene | 0.70 |
| PINK1 | activates | gene | 0.70 |
| MITOCHONDRIA | therapeutic_target | gene | 0.70 |
| NLRP3 | activates | gene | 0.70 |
| UBIQUITIN | activates | gene | 0.70 |
| INFLAMMATION | associated_with | gene | 0.70 |
| MIRNAS | regulates | gene | 0.70 |
| TNF | activates | gene | 0.70 |
| TNF-Α | activates | gene | 0.70 |
| GENES | regulates | gene | 0.70 |
| MICRORNAS | activates | gene | 0.70 |
| MICRORNAS | regulates | gene | 0.70 |
| OPTN | activates | gene | 0.70 |
| ALS | biomarker_for | gene | 0.70 |
| AMYOTROPHIC LATERAL SCLEROSIS | biomarker_for | gene | 0.70 |
| BCL2 | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-02 | 2 hypotheses Top: 0.490
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||