gene

IL-1B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL-1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

131Connections

0Hypotheses

1Analyses

50Outgoing

38Incoming

0Experiments

2Debates

No summary available yet.

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🧬 Gene Info

Gene Symbol	IL
Function	Interleukin-1 beta (IL-1β) is a potent pro-inflammatory cytokine that plays a central role in the innate immune response and neuroinflammation.
GeneCards	IL
Human Protein Atlas	IL
Associated Diseases	CRC
KG Connections	1 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    IL_1B["IL-1B"] -->|"associated"| IL_6["IL-6"]
    style IL_6 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    IL_1B["IL-1B"] -->|"associated"| TNF["TNF"]
    style TNF fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    IL_1B["IL-1B"] -->|"associated"| NF_KB["NF-KB"]
    style NF_KB fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    IL_1B["IL-1B"] -->|"associated"| NLRP3["NLRP3"]
    style NLRP3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    IL_1B["IL-1B"] -->|"associated"| NEURODEGENERATION["NEURODEGENERATION"]
    style NEURODEGENERATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    IL_1B["IL-1B"] -->|"associated"| MICROGLIA["MICROGLIA"]
    style MICROGLIA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    IL_1B["IL-1B"] -->|"associated"| PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    style PARKINSON_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated"| IL_1B["IL-1B"]
    style ALZHEIMER_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    AUTOPHAGY["AUTOPHAGY"] -->|"associated"| IL_1B["IL-1B"]
    style AUTOPHAGY fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    APOPTOSIS["APOPTOSIS"] -->|"associated"| IL_1B["IL-1B"]
    style APOPTOSIS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Palmitoleic_Acid["Palmitoleic Acid"] -->|"regulates"| IL_1B["IL-1B"]
    style Palmitoleic_Acid fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    AMYLOID["AMYLOID"] -->|"associated"| IL_1B["IL-1B"]
    style AMYLOID fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    style IL_1B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (93)

Target	Relation	Type	Str
IL-6	associated_with	gene	1.00
NF-KB	associated_with	protein	1.00
NLRP3	associated_with	gene	1.00
TNF	associated_with	gene	1.00
PARKINSON'S DISEASE	associated_with	disease	0.82
MICROGLIA	associated_with	cell_type	0.82
Neuronal Injury	contributes_to	process	0.80
MMP9	associated_with	gene	0.74
TLR4	associated_with	gene	0.72
complement gene expression	activates	process	0.70
SUBSTANTIA NIGRA	associated_with	brain_region	0.66
MAPT	associated_with	gene	0.66
TLR2	associated_with	gene	0.66
PI3K	associated_with	gene	0.66
Necroptosis	activates	disease	0.65
Prion Disease	expressed_in	disease	0.65
Depression	inhibits	disease	0.65
Epilepsy	inhibits	disease	0.65
Als	inhibits	disease	0.65
Alzheimer	expressed_in	disease	0.65
Parkinson	expressed_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Neuroinflammation	inhibits	disease	0.65
UBIQUITIN	associated_with	protein	0.64
Chemokine	expressed_in	protein	0.60
Cytokine	expressed_in	protein	0.60
TNF	inhibits	gene	0.60
EPILEPSY	inhibits	gene	0.60
DEPRESSION	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
IL-1	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
Nf-Κb	inhibits	pathway	0.60
Microglia	inhibits	cell_type	0.60
Neuron	inhibits	cell_type	0.60
CX3CL1	expressed_in	gene	0.60
Caspase	inhibits	protein	0.60
ALZHEIMER	expressed_in	gene	0.60
MICROGLIA	expressed_in	gene	0.60
CXCL10	expressed_in	gene	0.60
PARKINSON	expressed_in	gene	0.60
Microglia	expressed_in	cell_type	0.60
Neuron	expressed_in	cell_type	0.60
Il-1	inhibits	protein	0.60
Rb	activates	protein	0.60
GASDERMIN	activates	gene	0.60
Macrophage	activates	cell_type	0.60
Endothelial	activates	cell_type	0.60
Il-1	activates	protein	0.60
Caspase	activates	protein	0.60

Incoming (38)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
Musk	downregulates	drug	0.95
Palmitoleic Acid	downregulates	compound	0.85
AMYLOID	associated_with	protein	0.82
PPAR-GAMMA	decreases	protein	0.80
sesquiterpenoids	downregulates	compound	0.75
AKT	associated_with	gene	0.74
CASP3	associated_with	gene	0.72
APOE	associated_with	gene	0.66
APP	associated_with	gene	0.66
BAX	associated_with	gene	0.64
BCL2	associated_with	gene	0.64
CALR	inhibits	gene	0.60
PAH	activates	gene	0.60
CANX	inhibits	gene	0.60
APOPTOSIS	activates	gene	0.60
PYCARD	activates	gene	0.60
APAF1	inhibits	gene	0.60
CASP4	activates	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
CXCL10	expressed_in	gene	0.60
MICROGLIA	expressed_in	gene	0.60
RIPK1	inhibits	gene	0.60
TNFSF10	activates	gene	0.60
CX3CR1	expressed_in	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
PARKINSON	expressed_in	gene	0.60
MICROGLIA	inhibits	gene	0.60
TLR4	inhibits	gene	0.60
CX3CL1	expressed_in	gene	0.60
microglia	activates	cell_type	0.50
CXCL10	activates	gene	0.50
CYTOKINES	activates	concept	0.50
AMPK	associated_with	gene	0.48
ASTROCYTES	associated_with	cell_type	0.48
BDNF	associated_with	gene	0.48
EGFR	associated_with	gene	0.48
BECN1	associated_with	gene	0.48

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 15 hypotheses Top: 0.822

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Hypothesis debate: SASP-Mediated Complement Cascade Amplification

closed · Rounds: 4 · Score: 0.40 · 2026-04-27

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP

closed · Rounds: 4 · Score: 0.89 · 2026-04-06

Related Research

Hypotheses and analyses mentioning IL-1B in their description or question text

No additional research found