concept

MONOCYTES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MONOCYTES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

279Connections

1Hypotheses

0Analyses

49Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	MONOCYTES
Key Genes/Proteins	STAT3, CLU, CR1
Related Diseases	CELL DEATH, INFLAMMATION, STROKE, MENINGITIS
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    MONOCYTES["MONOCYTES"]
    style MONOCYTES fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    MONOCYTES -->|"mediates"| Pro_inflammatory_Signals["Pro-inflammatory Signals"]
    MONOCYTES -->|"causes"| STROKE["STROKE"]
    MONOCYTES -->|"interacts"| NECROPTOSIS["NECROPTOSIS"]
    MONOCYTES -->|"accumulates_in"| NEUTROPHIL["/NEUTROPHIL/"]
    MONOCYTES -->|"interacts"| BBB((BBB))
    MONOCYTES -->|"activates"| PARP1([PARP1])
    MONOCYTES -->|"activates"| SIRT6([SIRT6])
    MONOCYTES -->|"activates"| T_CELL["/T CELL/"]
    MONOCYTES -->|"activates"| T_CELLS["/T CELLS/"]
    MONOCYTE["/MONOCYTE/"] -->|"interacts"| MONOCYTES
    MENINGITIS["MENINGITIS"] -->|"accumulates_in"| MONOCYTES
    MACROPHAGE["/MACROPHAGE/"] -->|"interacts"| MONOCYTES
    MACROPHAGES["/MACROPHAGES/"] -->|"interacts"| MONOCYTES

Outgoing (57)

Target	Relation	Type	Str
ENDOTHELIAL CELLS	activates	cell_type	0.70
CELL DEATH	activates	phenotype	0.70
INFLAMMATION	interacts_with	phenotype	0.70
STROKE	causes	disease	0.65
NEUTROPHIL	accumulates_in	cell_type	0.65
NEUTROPHIL	interacts_with	cell_type	0.65
CLU	interacts_with	gene	0.65
MACROPHAGES	produces	cell_type	0.65
CR1	treats	gene	0.65
BBB	interacts_with	brain_region	0.64
PARP1	activates	gene	0.60
SIRT6	activates	gene	0.60
T CELL	activates	cell_type	0.60
T CELLS	activates	cell_type	0.60
T CELL	contributes_to	cell_type	0.60
T CELLS	contributes_to	cell_type	0.60
CSF	expressed_in	phenotype	0.55
BLOOD_BRAIN_BARRIER	interacts_with	brain_region	0.50
PARP1	co_discussed	entity	0.50
SIRT6	co_discussed	entity	0.50
T CELL	co_discussed	entity	0.50
FIBROBLASTS	expressed_in	concept	0.50
HEPATOCYTES	interacts_with	concept	0.50
DENDRITIC CELLS	interacts_with	concept	0.50
FIBROBLASTS	activates	concept	0.50
DENDRITIC CELLS	expressed_in	concept	0.50
NEUTROPHILS	associated_with	concept	0.50
NEUTROPHILS	interacts_with	concept	0.50
CELL MIGRATION	activates	concept	0.50
EXOSOME	associated_with	organelle	0.45
TH	co_discussed	gene	0.40
NEUTROPHIL	co_discussed	cell_type	0.40
PYCARD	co_discussed	gene	0.40
T CELLS	co_discussed	cell_type	0.40
ROS	implicated_in	protein	0.35
NK CELLS	implicated_in	cell_type	0.35
PULMONARY FIBROSIS	implicated_in	disease	0.35
PULMONARY FIBROSIS	causes	disease	0.35
T CELLS	implicated_in	cell_type	0.35
STROKE	inhibits	disease	0.35
NECROPTOSIS	activates	process	0.35
NEUTROPHILS	biomarker_for	cell_type	0.35
NEUTROPHILS	contributes_to	cell_type	0.35
NEUTROPHILS	recruits	cell_type	0.35
ROS	activates	protein	0.35
SPINAL CORD	inhibits	brain_region	0.35
PHAGOCYTOSIS	therapeutic_target	process	0.35
SPINAL CORD INJURY	activates	disease	0.35
T CELLS	inhibits	cell_type	0.35

Incoming (222)

Source	Relation	Type	Str
MACROPHAGES	inhibits	cell_type	0.95
ENDOTHELIAL CELLS	interacts_with	cell_type	0.70
STAT3	activates	gene	0.70
MONOCYTE	interacts_with	cell_type	0.65
MONOCYTE	causes	cell_type	0.65
MENINGITIS	accumulates_in	disease	0.65
MONOCYTE	accumulates_in	cell_type	0.65
MACROPHAGE	interacts_with	cell_type	0.65
MACROPHAGES	interacts_with	cell_type	0.65
MACROPHAGE	sensitizes_to	cell_type	0.65
MACROPHAGES	sensitizes_to	cell_type	0.65
MONOCYTE	sensitizes_to	cell_type	0.65
MONOCYTE	increases	cell_type	0.65
CCL2	activates	gene	0.65
ATHEROSCLEROSIS	reduces	disease	0.65
DIABETES	expressed_in	disease	0.65
DIABETES	causes	disease	0.65
MACROPHAGES	causes	cell_type	0.65
INFLAMMATION	activates	process	0.65
ATHEROSCLEROSIS	interacts_with	disease	0.65
IL33	activates	gene	0.65
CR1	causes	gene	0.65
MICROGLIA	biomarker_for	cell_type	0.60
MACROPHAGE	expressed_in	cell_type	0.60
MACROPHAGES	expressed_in	cell_type	0.60
MONOCYTE	expressed_in	cell_type	0.60
CD38	activates	gene	0.60
MACROPHAGE	activates	cell_type	0.60
MACROPHAGES	activates	cell_type	0.60
MONOCYTE	activates	cell_type	0.60
ENDOTHELIAL	interacts_with	cell_type	0.60
ASTROCYTE	activates	cell_type	0.60
ASTROCYTES	activates	cell_type	0.60
CCL2	regulates	gene	0.60
MICROGLIA	activates	cell_type	0.60
MICROGLIA	expressed_in	cell_type	0.60
LDLR	expressed_in	gene	0.60
MONOCYTE	contributes_to	cell_type	0.60
ISCHEMIC	expressed_in	disease	0.60
MACROPHAGE	protects_against	cell_type	0.60
MONOCYTE	protects_against	cell_type	0.60
B CELL	promotes	cell_type	0.60
MONOCYTE	promotes	cell_type	0.60
ASTROCYTE	expressed_in	cell_type	0.60
ATHEROSCLEROSIS	promotes	disease	0.60
BIN1	regulates	gene	0.60
GM_CSF	activates	protein	0.56
MICROGLIA	co_discussed	entity	0.50
MONOCYTE	co_discussed	entity	0.50
MACROPHAGE	co_discussed	entity	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2 Agonism to Reprogram Infiltrated Monocytes Toward Neur	0.584	neurodegeneration	What are the specific molecular mechanis

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MONOCYTES

Understanding Entity Pages

Wiki Pages (20)

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Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

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Microglial Cells — Cell Type Hierarchy

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

Astrocyte Reactivity Mechanism

CLCN10 — Chloride Voltage-Gated Channel 10

Blood-Brain Barrier Dysfunction in Neurodegeneration

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

Blood-Brain Barrier Biology and Crossing Strategies

substantia-nigra

nlrc5-protein

LRRK2 Pathway in Parkinson's Disease

NPAS3 Gene

Ion Channel Dysfunction in Huntington's Disease

Transcriptional Regulation in Neurodegeneration

Psychobiotic Therapy for Neurodegenerative Diseases