concept

INSULIN RECEPTOR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INSULIN RECEPTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

124Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	INSULIN RECEPTOR
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    INSULIN_RECEPTOR["INSULIN RECEPTOR"]
    INSULIN_RECEPTOR -->|"mediates"| PI3K_Inhibitor_Resistance["PI3K Inhibitor Resistance"]
    INSULIN_RECEPTOR -->|"interacts"| RNA_polymerase_II["RNA polymerase II"]
    INSULIN_RECEPTOR -->|"interacts"| HCF1["HCF1"]
    INSULIN_RECEPTOR -->|"causes"| Insulin_Resistance["Insulin Resistance"]
    INSULIN_RECEPTOR -->|"inhibits"| Diabetes["Diabetes"]
    INSULIN_RECEPTOR -->|"inhibits"| Alzheimer["Alzheimer"]
    INSULIN_RECEPTOR -->|"inhibits"| Neurodegeneration["Neurodegeneration"]
    Metformin["Metformin"] -->|"downregulates"| INSULIN_RECEPTOR
    INSR["INSR"] -->|"encodes"| INSULIN_RECEPTOR
    insulin["insulin"] -->|"activates"| INSULIN_RECEPTOR
    PKC["PKC"] -->|"target for"| INSULIN_RECEPTOR
    PIK3CA["PIK3CA"] -->|"target for"| INSULIN_RECEPTOR
    PI3K["PI3K"] -->|"inhibits"| INSULIN_RECEPTOR
    MTOR["MTOR"] -->|"target for"| INSULIN_RECEPTOR
    VGLUT1["VGLUT1"] -->|"inhibits"| INSULIN_RECEPTOR

Outgoing (57)

Target	Relation	Type	Str
insulin signaling	activates	pathway	0.90
neural stem cells	expressed_in	cell_type	0.80
RNA polymerase II	interacts_with	protein	0.70
HCF1	interacts_with	protein	0.70
neurodegeneration	associated_with	disease	0.70
diabetes	associated_with	disease	0.70
Insulin Resistance	causes	phenotype	0.70
blood-brain barrier	expressed_in	brain_region	0.70
Diabetes	inhibits	disease	0.60
Alzheimer	inhibits	disease	0.60
Neurodegeneration	inhibits	disease	0.60
Alzheimer	protects_against	disease	0.60
Als	protects_against	disease	0.60
Alzheimer	activates	disease	0.60
Als	activates	disease	0.60
Diabetes	therapeutic_target	disease	0.60
Neuropathy	therapeutic_target	disease	0.60
Neuroinflammation	associated_with	disease	0.60
Ferroptosis	expressed_in	disease	0.60
Alzheimer	expressed_in	disease	0.60
Aging	expressed_in	disease	0.60
Dementia	expressed_in	disease	0.60
Diabetes	expressed_in	disease	0.60
Diabetes	activates	disease	0.60
Parkinson	activates	disease	0.60
Epilepsy	activates	disease	0.60
Obesity	activates	disease	0.60
Alzheimer	contributes_to	disease	0.60
Als	contributes_to	disease	0.60
Dementia	therapeutic_target	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Als	therapeutic_target	disease	0.60
Neuroinflammation	causes	disease	0.60
hippocampus	expressed_in	brain_region	0.60
neurons	expressed_in	cell_type	0.60
astrocytes	expressed_in	cell_type	0.60
Ferroptosis Pathway	expressed_in	pathway	0.55
Pi3K/Akt	therapeutic_target	pathway	0.55
Mtor	therapeutic_target	pathway	0.55
Blood-Brain Barrier	therapeutic_target	pathway	0.55
Mtor	protects_against	pathway	0.55
Lipid Metabolism	therapeutic_target	pathway	0.55
Insulin Signaling	therapeutic_target	pathway	0.55
Oxidative Stress	associated_with	pathway	0.55
Apoptosis	therapeutic_target	pathway	0.55
Oxidative Stress	expressed_in	pathway	0.55
Blood-Brain Barrier	expressed_in	pathway	0.55
Oxidative Stress	activates	pathway	0.55
Insulin Signaling	activates	pathway	0.55
Oxidative Stress	contributes_to	pathway	0.55

Incoming (67)

Source	Relation	Type	Str
insulin	activates	drug	0.70
INSR	encodes	gene	0.70
Alzheimer's disease	involves	disease	0.70
PKC	therapeutic_target	gene	0.60
PIK3CA	therapeutic_target	gene	0.60
PI3K	inhibits	gene	0.60
MTOR	therapeutic_target	gene	0.60
VGLUT1	inhibits	gene	0.60
AKT	protects_against	gene	0.60
MTOR	protects_against	gene	0.60
BACE1	regulates	gene	0.60
CLUSTERIN	activates	gene	0.60
CLU	regulates	gene	0.60
FNDC5	activates	gene	0.60
PI3K	activates	gene	0.60
TAU	phosphorylates	gene	0.60
AKT	activates	gene	0.60
TAU	activates	gene	0.60
TAU	contributes_to	gene	0.60
MTOR	contributes_to	gene	0.60
TAU	protects_against	gene	0.60
TAU	causes	gene	0.60
TREM2	implicated_in	gene	0.60
PI3K	inhibits	gene	0.60
PI3K	phosphorylates	gene	0.60
neurodegeneration	involves	disease	0.60
BACE1	activates	gene	0.60
BACE1	expressed_in	gene	0.60
BACE1	inhibits	gene	0.60
BACE1	regulates	gene	0.60
APOE	regulates	gene	0.60
obesity	involves	disease	0.60
APOE	interacts_with	gene	0.60
ALZHEIMER	inhibits	gene	0.60
ASTROCYTES	protects_against	gene	0.60
ALZHEIMER	protects_against	gene	0.60
ALZHEIMER	activates	gene	0.60
AMYLOID	activates	gene	0.60
ASTROCYTES	regulates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
AXON	therapeutic_target	gene	0.60
FERROPTOSIS	expressed_in	gene	0.60
PERICYTE	expressed_in	gene	0.60
AMYLOID	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
DEMENTIA	expressed_in	gene	0.60
INSR	expressed_in	gene	0.60
AGING	expressed_in	gene	0.60
EXERCISE	activates	gene	0.60
PARKINSON	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

INSULIN RECEPTOR

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Growth Factor Therapies

Blood-Brain Barrier Biology and Crossing Strategies

blood-brain-barrier

Insulin Signaling in Parkinson's Disease

metabolic-dysfunction-neurodegeneration

Nanomedicine Approaches to Alzheimer's Disease

Advanced Glycation End Products in Neurodegeneration

bbb-transport-mechanisms

JAK-STAT Signaling Pathway in Neurodegeneration

Amyloid Precursor Protein (APP)

alpha-lipoic-acid-neurodegeneration

Type 3 Diabetes Hypothesis of Alzheimer's Disease

blood-brain-barrier-endothelial-cells

Receptor-Mediated Transcytosis (RMT)

Metabolic Dysfunction in Corticobasal Degeneration

LRP1B — Low Density Lipoprotein Receptor-Related Protein 1B

Viral Vector Delivery Investment Landscape for Neurodegeneration