concept

AHR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AHR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

457Connections

3Hypotheses

2Analyses

50Outgoing

50Incoming

1Experiments

2Debates

Summary

AHR is a concept in neurodegeneration research. Key relationships include: inhibits, activates, associated with. Associated with ALS, Aging, Als. Connected to 274 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	AHR
Key Genes/Proteins	AADC, Actin, AGING, AKT, ALDH, ALZHEIMER DISEASE
Related Diseases	Aging, Als, ALS, Alzheimer, ALZHEIMER
Related Pathways	Adaptive Immunity, Amyloid
Linked Hypotheses	1 hypotheses

🧬 3D Structure Comparison — AHR Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

5NJ8 — X-ray / Cryo-EM

🔮 AI Predicted Structure

A0A2R8Y7G1 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    AHR["AHR"]
    AHR -->|"inhibits"| SYNAPTOPHYSINSYP["SYNAPTOPHYSINSYP"]
    AHR -.protects against.-> Alzheimer_s_disease["Alzheimer's disease"]
    AHR -->|"inhibits"| RAGE_NF__B["RAGE/NF-kappaB"]
    AHR -->|"inhibits"| microglia["microglia"]
    AHR -->|"regulates"| Parkinson["Parkinson"]
    AHR -->|"regulates"| Als["Als"]
    AHR -->|"activates"| Inflammation["Inflammation"]
    AHR -->|"inhibits"| Ms["Ms"]
    AHR -->|"activates"| Fibrosis["Fibrosis"]
    h_f9c6fa3f["h-f9c6fa3f"] -->|"targets"| AHR
    Indoles["Indoles"] -->|"activates"| AHR
    indoleacetic_acid["indoleacetic acid"] -->|"activates"| AHR
    BENVITIMOD["BENVITIMOD"] -->|"activates"| AHR
    CLDN1["CLDN1"] -->|"inhibits"| AHR
    NRF2["NRF2"] -->|"inhibits"| AHR
    ARNT["ARNT"] -->|"activates"| AHR
    CTSS["CTSS"] -->|"inhibits"| AHR
    P62["P62"] -->|"activates"| AHR
    CYTOKINES["CYTOKINES"] -->|"inhibits"| AHR

Outgoing (329)

Target	Relation	Type	Str
Als	inhibits	disease	0.95
Inflammation	activates	disease	0.95
Inflammation	inhibits	disease	0.95
Alzheimer's Disease	associated_with	disease	0.90
INFLAMMATION	inhibits	gene	0.90
Retinal Ganglion Cell Apoptosis	inhibits	process	0.85
Retinal Ischemia/Reperfusion Injury	protects_against	disease	0.85
Aging	regulates	disease	0.85
glaucoma	protects_against	disease	0.82
eNOS	associated_with	enzyme	0.80
Oxidative Stress	associated_with	process	0.80
SYNAPTOPHYSINSYP	inhibits	gene	0.80
ERK	inhibits	protein	0.80
Immune Response	regulates	pathway	0.80
Als	activates	disease	0.75
Glaucoma	associated_with	disease	0.75
Cancer	regulates	disease	0.75
Als	regulates	disease	0.75
Tumor	inhibits	disease	0.75
Inflammation	regulates	disease	0.75
Als	therapeutic_target	disease	0.75
RAGE/NF-κB	inhibits	pathway	0.70
Nf-Κb	regulates	pathway	0.70
IPA	activates	protein	0.70
Microbiota	inhibits	pathway	0.70
microglia	inhibits	cell_type	0.70
ILC3 IL-22 production	activates	mechanism	0.70
Alzheimer's disease	protects_against	disease	0.70
ALS	regulates	disease	0.65
Glaucoma	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
ALS	expressed_in	disease	0.65
Alzheimer	activates	disease	0.65
Aging	associated_with	disease	0.65
ALS	activates	disease	0.65
Ischemia	regulates	disease	0.65
Neurodegeneration	contributes_to	disease	0.65
Dementia	associated_with	disease	0.65
Parkinson	regulates	disease	0.65
Als	associated_with	disease	0.65
Depression	activates	disease	0.65
Cardiovascular	associated_with	disease	0.65
Hypertension	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Pneumonia	regulates	disease	0.65
Asthma	regulates	disease	0.65
Ms	activates	disease	0.65
Fibrosis	activates	disease	0.65
Cancer	associated_with	disease	0.65

Incoming (128)

Source	Relation	Type	Str
ITE	activates	drug	0.92
h-f9c6fa3f	targets	hypothesis	0.90
Tryptophan Metabolites	activates	compound	0.90
Kynurenine Metabolites	activates	compound	0.85
Indoles	upregulates	chemical	0.80
NF-ΚB	regulates	gene	0.70
AGING	regulates	gene	0.70
CANCER	regulates	gene	0.70
IPA	activates	gene	0.70
indoleacetic acid	activates	drug	0.70
Indoles	activates	process	0.70
INFLAMMATION	activates	gene	0.70
BENVITIMOD	activates	drug	0.64
ARNT	activates	gene	0.60
CTSS	inhibits	gene	0.60
ALDH	activates	gene	0.60
CLDN1	inhibits	gene	0.60
NRF2	inhibits	gene	0.60
DEPRESSION	activates	gene	0.60
WNT	activates	gene	0.60
GENES	activates	gene	0.60
P62	activates	gene	0.60
LAMP2	inhibits	gene	0.60
MTOR	regulates	gene	0.60
MYC	regulates	gene	0.60
XPA	regulates	gene	0.60
CLOCK	interacts_with	gene	0.60
PDIA3	regulates	gene	0.60
BMAL1	interacts_with	gene	0.60
NLRP3	activates	gene	0.60
BCL2L1	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
CYCS	therapeutic_target	gene	0.60
EGF	associated_with	gene	0.60
HSP90AA1	therapeutic_target	gene	0.60
CASP3	therapeutic_target	gene	0.60
RORA	associated_with	gene	0.60
BMP7	associated_with	gene	0.60
CX3CR1	associated_with	gene	0.60
STAT6	activates	gene	0.60
OCLN	inhibits	gene	0.60
STAT3	inhibits	gene	0.60
HK2	inhibits	gene	0.60
CGAS	activates	gene	0.60
NEPRILYSIN	activates	gene	0.60
IDO1	activates	gene	0.60
VEGF	activates	gene	0.60
MITOCHONDRIAL DNA	activates	gene	0.60
ROS	inhibits	gene	0.60
DEMENTIA	associated_with	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Aryl Hydrocarbon Receptor (AHR) Activation in B Cells Determ	0.738	neuroinflammation	How do B cells mechanistically orchestra
Aryl Hydrocarbon Receptor (AhR) Activation by Microbiome Met	0.597	neuroinflammation	What molecular mechanisms determine whet
Gut Bacterial Metabolite-AhR Dysregulation Converts SCFA-Def	0.580	neurodegeneration	How does gut microbiome dysbiosis contri