concept

AHR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AHR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

465Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

1Experiments

1Debates

Summary

AHR is a concept in neurodegeneration research. Key relationships include: inhibits, activates, associated with. Associated with ALS, Aging, Als. Connected to 274 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	AHR
Key Genes/Proteins	AADC, Actin, AGING, AKT, ALDH, ALZHEIMER DISEASE
Related Diseases	Aging, Als, ALS, Alzheimer, ALZHEIMER
Related Pathways	Adaptive Immunity, Amyloid
Linked Hypotheses	1 hypotheses

🧬 3D Structure Comparison — AHR Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

5NJ8 — X-ray / Cryo-EM

🔮 AI Predicted Structure

A0A2R8Y7G1 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    AHR["AHR"]
    AHR -->|"inhibits"| SYNAPTOPHYSINSYP["SYNAPTOPHYSINSYP"]
    AHR -.protects against.-> Alzheimer_s_disease["Alzheimer's disease"]
    AHR -->|"inhibits"| RAGE_NF__B["RAGE/NF-kappaB"]
    AHR -->|"inhibits"| microglia["microglia"]
    AHR -->|"regulates"| Parkinson["Parkinson"]
    AHR -->|"regulates"| Als["Als"]
    AHR -->|"activates"| Inflammation["Inflammation"]
    AHR -->|"inhibits"| Ms["Ms"]
    AHR -->|"activates"| Fibrosis["Fibrosis"]
    h_f9c6fa3f["h-f9c6fa3f"] -->|"targets"| AHR
    Indoles["Indoles"] -->|"activates"| AHR
    indoleacetic_acid["indoleacetic acid"] -->|"activates"| AHR
    BENVITIMOD["BENVITIMOD"] -->|"activates"| AHR
    CLDN1["CLDN1"] -->|"inhibits"| AHR
    NRF2["NRF2"] -->|"inhibits"| AHR
    ARNT["ARNT"] -->|"activates"| AHR
    CTSS["CTSS"] -->|"inhibits"| AHR
    P62["P62"] -->|"activates"| AHR
    CYTOKINES["CYTOKINES"] -->|"inhibits"| AHR

Outgoing (335)

Target	Relation	Type	Str
Als	inhibits	disease	0.95
Inflammation	activates	disease	0.95
Inflammation	inhibits	disease	0.95
Alzheimer's Disease	associated_with	disease	0.90
INFLAMMATION	inhibits	gene	0.90
Aging	regulates	disease	0.85
Retinal Ganglion Cell Apoptosis	inhibits	process	0.85
Retinal Ischemia/Reperfusion Injury	protects_against	disease	0.85
glaucoma	protects_against	disease	0.82
eNOS	associated_with	enzyme	0.80
Oxidative Stress	associated_with	process	0.80
SYNAPTOPHYSINSYP	inhibits	gene	0.80
ERK	inhibits	protein	0.80
Immune Response	regulates	pathway	0.80
Tumor	inhibits	disease	0.75
Als	regulates	disease	0.75
Inflammation	regulates	disease	0.75
Als	therapeutic_target	disease	0.75
Cancer	regulates	disease	0.75
Glaucoma	associated_with	disease	0.75
Als	activates	disease	0.75
IPA	activates	protein	0.70
Nf-Κb	regulates	pathway	0.70
microglia	inhibits	cell_type	0.70
RAGE/NF-κB	inhibits	pathway	0.70
Alzheimer's disease	protects_against	disease	0.70
Microbiota	inhibits	pathway	0.70
Multiple Sclerosis	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Glioblastoma	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Fibrosis	associated_with	disease	0.65
Als	contributes_to	disease	0.65
Alzheimer	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Obesity	associated_with	disease	0.65
ALS	inhibits	disease	0.65
Ms	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Hypertension	inhibits	disease	0.65
Asthma	contributes_to	disease	0.65
Hepatitis	associated_with	disease	0.65
Als	associated_with	disease	0.65
Leukemia	associated_with	disease	0.65
Autoimmune	associated_with	disease	0.65
ALS	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Cancer	inhibits	disease	0.65
Asthma	regulates	disease	0.65

Incoming (130)

Source	Relation	Type	Str
ITE	activates	drug	0.92
h-f9c6fa3f	targets_gene	hypothesis	0.90
Tryptophan Metabolites	activates	compound	0.90
Kynurenine Metabolites	activates	compound	0.85
Indoles	upregulates	chemical	0.80
h-f9c6fa3f	targets	hypothesis	0.80
NF-ΚB	regulates	gene	0.70
AGING	regulates	gene	0.70
indoleacetic acid	activates	drug	0.70
INFLAMMATION	activates	gene	0.70
Indoles	activates	process	0.70
CANCER	regulates	gene	0.70
IPA	activates	gene	0.70
BENVITIMOD	activates	drug	0.64
CTSS	inhibits	gene	0.60
NLRP3	activates	gene	0.60
APP	activates	gene	0.60
NEPRILYSIN	activates	gene	0.60
IDO1	activates	gene	0.60
ANGPT1	activates	gene	0.60
NOTCH3	activates	gene	0.60
CLDN1	inhibits	gene	0.60
NRF2	inhibits	gene	0.60
ARNT	activates	gene	0.60
NF-ΚB	activates	gene	0.60
NEP	activates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
CANCER	therapeutic_target	gene	0.60
CYTOKINES	associated_with	gene	0.60
DIABETES MELLITUS	associated_with	gene	0.60
ROS	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
IL-13	activates	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
AMYLOID	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
APP/PS1	activates	gene	0.60
DEPRESSION	treats	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
AND	associated_with	gene	0.60
RORC	inhibits	gene	0.60
PER	associated_with	gene	0.60
XPA	regulates	gene	0.60
CLOCK	interacts_with	gene	0.60
PDIA3	regulates	gene	0.60
BMAL1	interacts_with	gene	0.60
RORA	associated_with	gene	0.60
BMP7	associated_with	gene	0.60
CX3CR1	associated_with	gene	0.60
TLR4	inhibits	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Aryl Hydrocarbon Receptor (AHR) Activation in B Cells Determ	0.683	neuroinflammation	How do B cells mechanistically orchestra

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 20 hypotheses Top: 0.888

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
IL-10 deficiency and VLC ceramide accumulation in inflammatory bowel d	validation	inflammatory bowel disease	0.900	0.00	IL-10 knockout mice	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What are the mechanisms underlying what are the mechanisms by which gut microbio

closed · Rounds: 4 · Score: 0.95 · 2026-04-01