gene

SST

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SST: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

447Connections
30Hypotheses
3Analyses
50Outgoing
50Incoming
12Experiments
20Debates

Summary

SST is a gene implicated in neurodegeneration research. Key relationships include: inhibits, therapeutic target, implicated in. Associated with Alzheimer's disease, Depression, Ms. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolSST
Chromosome3q28
Protein TypeLigand
Target ClassLigand
FunctionThe SST gene encodes preprosomatostatin, which is processed to somatostatin-14 (the major form in the brain) and somatostatin-28 (predominant in the gut).
Mechanism of ActionSomatostatin is a peptide neurotransmitter that modulates neuronal signaling by inhibiting hormone release and neuronal excitability, with emerging evidence suggesting its potential neuroprotective role in neurodegenerative processes through regulation of inflammatory responses and synaptic plasticity. In neurodegeneration contexts, SST receptors may serve as modulators of neuroinflammatory cascades and potentially mitigate progressive neuronal damage through receptor-mediated signaling mechanisms.
DruggabilityLow (0.41)
Clinical StageApproved
Amino Acids14 aa
PathwaysAmyloid, affective empathy, gamma_oscillation, neuropeptide signaling, sleep-dependent growth hormone
UniProt IDP61278
Ensembl IDENSG00000136744
GeneCardsSST
Human Protein AtlasSST
MorphologyLamp5 Lhx6 neuron (source: Cell Ontology)
Associated DiseasesAls, Alzheimer, alzheimer_s_disease, Alzheimer's disease
Known Drugs/CompoundsOctreotide, Lanreotide
InteractionsActin, Albumin, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-Β PLAQUES
SciDEX TargetView Target Profile (8 clinical trials)
SciDEX HypothesesClosed-loop transcranial focused ultrasound target
Closed-loop transcranial focused ultrasound target
Gamma entrainment therapy to restore hippocampal-c (+17 more)
KG Connections445 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: SST — AlphaFold P61278 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

Cortical Ivy Cells

cell · 2948 words

Validated Hypothesis: Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to restore hippocampal gamma oscillations via upstream perforant path gating in Alzheimer's disease

hypothesis · 5341 words

Validated Hypothesis: Hypothesis 7: SST-SST1R/Gamma Entrainment-Enhanced Astrocyte Secretome

hypothesis · 4964 words

Validated Hypothesis: Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST interneurons to restore hippocampal-prefrontal synchrony in early AD

hypothesis · 4083 words

SST Protein — Somatostatin

protein · 2112 words

Cortical SST Detector Cells

cell · 1121 words

Pathway Diagram

graph TD
    SST["SST"]
    Alzheimer_s_disease{"Alzheimer's disease"}
    SST -->|"therapeutic target"| Alzheimer_s_disease
    gamma_oscillation(["gamma_oscillation"])
    SST -->|"regulates"| gamma_oscillation
    Ms{"Ms"}
    SST -->|"inhibits"| Ms
    Depression{"Depression"}
    SST -->|"inhibits"| Depression
    MMP3["MMP3"]
    SST -->|"inhibits"| MMP3
    Synaptic_Plasticity(["Synaptic Plasticity"])
    SST -->|"inhibits"| Synaptic_Plasticity
    Long_Term_Potentiation(["Long-Term Potentiation"])
    SST -->|"inhibits"| Long_Term_Potentiation
    MMP9["MMP9"]
    SST -->|"inhibits"| MMP9
    SST -->|"implicated in"| Alzheimer_s_disease
    neurodegeneration["neurodegeneration"]
    SST -->|"implicated in"| neurodegeneration
    h_bdbd2120["h-bdbd2120"]
    h_bdbd2120 -->|"therapeutic target"| SST
    h_bdbd2120 -->|"targets"| SST
    MMP9 -->|"inhibits"| SST
    style SST fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (288)

TargetRelationTypeStr
cortexexpressed_inbrain_region0.90
neuronsregulatescell_type0.90
interneuronsregulatescell_type0.90
Temporal Lobe Epilepsyassociated_withdisease0.90
neuronsexpressed_incell_type0.90

Incoming (159)

SourceRelationTypeStr
h-var-4d43a26612targets_genehypothesis0.90
h-var-d33964b962targets_genehypothesis0.90
h-var-f110ef2e0atargets_genehypothesis0.90
h-var-55da4f915dtargets_genehypothesis0.90
h-var-b7e4505525targets_genehypothesis0.90

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Closed-loop transcranial focused ultrasound targeting EC-II 0.968 alzheimers Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II 0.955 alzheimers Circuit-level neural dynamics in neurode
Gamma entrainment therapy to restore hippocampal-cortical sy 0.946 alzheimers Circuit-level neural dynamics in neurode
TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegener 0.892 neurodegeneration Gene expression changes in aging mouse b
Beta-frequency entrainment therapy targeting PV interneuron- 0.884 alzheimers Circuit-level neural dynamics in neurode
Hypothesis 7: SST-SST1R/Gamma Entrainment-Enhanced Astrocyte 0.839 neurodegeneration Which specific factors in conditioned me
Real-time gamma-guided transcranial focused ultrasound targe 0.827 alzheimers Circuit-level neural dynamics in neurode
Closed-loop tACS targeting entorhinal cortex layer II SST in 0.784 alzheimers Circuit-level neural dynamics in neurode
Alpha-gamma cross-frequency coupling enhancement to restore 0.775 alzheimers Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo 0.767 alzheimers Circuit-level neural dynamics in neurode
TREM2 Crosstalk and Synergistic Activation of Phagocytic Tra 0.761 neuroinflammation What molecular mechanisms mediate SPP1-i
Closed-loop tACS targeting EC-II SST interneurons to block t 0.752 alzheimers Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II SST interneur 0.748 alzheimers Circuit-level neural dynamics in neurode
TREM2-ASM Crosstalk in Microglial Lysosomal Senescence 0.713 neurodegeneration Gene expression changes in aging mouse b
Vascular Cell Type Crosstalk Driving Blood-Brain Barrier Bre 0.662 neurodegeneration Methodology challenge: dataset 'Allen Br
Closed-loop transcranial focused ultrasound targeting motor 0.633 als -
Closed-loop transcranial alternating current stimulation to 0.603 alzheimers Circuit-level neural dynamics in neurode
Cardiovascular-Neuroinflammation Crosstalk Interruption 0.587 alzheimers Neuroinflammation and microglial priming
Optogenetic restoration of hippocampal gamma oscillations vi 0.584 alzheimers Circuit-level neural dynamics in neurode
Gamma Entrainment Synergy: HBOT-Enhanced Cerebral Perfusion 0.583 neurodegeneration What are the optimal oxygen pressure, du
Closed-loop tACS targeting EC-II somatostatin interneurons t 0.564 alzheimers Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo 0.564 alzheimers Circuit-level neural dynamics in neurode
Excitatory/Inhibitory Balance Reversal via Somatostatin Inte 0.537 neurodegeneration Methodology challenge: dataset 'Allen Br
NAC + Ferrostatin-1 Combination for Peroxynitrite-Ferroptosi 0.530 neurodegeneration Can ferroptosis inhibitors prevent BBB d
Closed-loop neuromodulation-inspired cytokine axis suppressi 0.530 cell-biology -
Tripartite Synapse Cell Type-Nonautonomous Crosstalk: Coordi 0.510 neurodegeneration Cell type vulnerability debate in Alzhei
EC-II SST→PV Disinhibition Circuit Mechanism (Preclinical-On 0.460 alzheimers Closed-loop transcranial focused ultraso
Alpha-Beta Oscillation Coupling Enhances lncRNA-9969-Mediate 0.460 molecular-neurobiology How does lncRNA-0021 achieve sequence-sp
Alpha-theta entrainment therapy to enhance default mode netw 0.000 alzheimers Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo 0.000 alzheimers Circuit-level neural dynamics in neurode

Mentioning Analyses (3)

Scientific analyses that reference this entity

Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to

Alzheimer's disease | 2026-04-28 | 7 hypotheses Top: 0.670

Are interneuron oscillation deficits compensatory responses or primary pathologi

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.747

Circuit-level neural dynamics in neurodegeneration

neuroscience | 2026-04-03 | 73 hypotheses Top: 0.968

Experiments (12)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
Plant-based dietary patterns and Alzheimer's disease risk in multiethn clinical Alzheimer's disease and relate 0.950 0.00 human patients proposed N/A
Tet2 modulation in Aβ42-injured mouse hippocampal neurons exploratory Alzheimer's disease 0.900 0.00 primary mouse hippocampal neur proposed N/A
tFUS Targeting EC-II SST Interneurons Restores Hippocampal-Prefrontal in_vivo Alzheimer's disease 0.744 0.48 hAPP-J20 mice (n=10/group x 3 abandoned $110,000
Brain Connectivity-Targeted tACS Trial in Early AD clinical Alzheimer's Disease 0.509 0.50 human postmortem brain tissue proposed $520,000
s:** - Test whether HCN1 knockout specifically in EC layer II accelera falsification Alzheimer's Disease 0.400 0.50 cell_line proposed $80,000
AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Positive Indiv clinical Alzheimer's Disease 0.400 0.50 human proposed $6,550,000
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau clinical Alzheimer's Disease 0.400 0.50 cell_line proposed $180,000
Biomarker-Guided Sequential Therapy Selection in Alzheimer's Disease clinical Alzheimer's Disease 0.400 0.50 human proposed $5,460,000
tACS Connectivity Trial in Early Alzheimer's clinical Alzheimer's Disease 0.400 0.50 human proposed $5,460,000
Brain Connectivity-Targeted tACS Trial in Early AD clinical Alzheimer's Disease 0.400 0.50 mouse proposed $730,000
Cognitive Reserve Mechanisms in Alzheimer's Disease — Molecular Basis clinical Alzheimer's Disease 0.400 0.50 human completed $6,550,000
Cholinergic System Dysfunction in DLB — Mechanisms and Therapeutic Res clinical Alzheimer's Disease 0.400 0.50 human proposed $5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614] Han QQ, Shen SY, Liang LF, Chen XR, Yu J Brain Behav Immun 2024 1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704] Zhang T, Xu D, Trefts E, Lv M, Inuzuka H Science 2023 1
Anatomical and neurochemical profiles of somatostatin-positive neurons in the mo [PMID:41796787] Tomioka R, Kobayashi K, Song WJ Neuroscience 2026 0
Subtype-Specific Roles of Anterior Cingulate Cortex Neurons in Pain-Induced Soci [PMID:41799202] Wan X, Yan Z, Zhang Z, Liu X, Yang D, Zh Theranostics 2026 0
A comparative analysis of pig-to-rhesus corneal xenotransplantation with various [PMID:41928466] Lee SH, Yoon CH, Choi HJ, Lee HJ, Kang H Korean J Ophthalmol 2026 0
Epigenetically regulated pancreatic GABA-somatostatin signaling underlies gestat [PMID:41779871] Zhu H, Luo S, Liu C, Cheng Y, Ren Z, Mo Science translational medicine 2026 0
Therapeutic Potential of Somatostatin and Its Analogues in Alzheimer's Disease: [PMID:41854733] Liu K, Zhang XY, Wang YT, Wang R, Jin RH Molecular neurobiology 2026 0
Altered Expression of GABA-Related Genes in Schizophrenia: Insights from Meta-An [PMID:41788138] Singer Y, Yitzhaky A, Hertzberg L Alpha psychiatry 2026 0
Paracrine inhibition via G protein inwardly rectifying potassium channels regula [PMID:41824458] Panzer JK, Lang AL, Levi NJ, Garcia PA, Cell reports 2026 0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] ["Chen Kai", "Li Fuyao", "Zhang Shuwen", Journal of neuroinflammation 2025 0
GADD45G operates as a pathological sensor orchestrating reactive gliosis and neu [PMID:40409253] Shen T, Tai W, Jiang D, Ma S, Zhong X, Z Neuron 2025 0
Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheime [PMID:41035073] Castanho I, Naderi Yeganeh P, Boix CA, M Molecular neurodegeneration 2025 0
The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkins [PMID:39964974] Dai L, Wang J, Meng L, Zhang X, Xiao T, PLoS biology 2025 0
Molecular hallmarks of excitatory and inhibitory neuronal resilience and resista [PMID:39868232] Castanho I, Yeganeh PN, Boix CA, Morgan bioRxiv : the preprint server 2025 0
From stress to Alzheimer's: A circuit-based framework for prefrontal cognitive d [PMID:41115499] Yi JH Neuroscience letters 2025 0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] ["Chen Kai", "Li Fuyao", "Zhang Shuwen", Journal of neuroinflammation 2025 0
Hippocampal Interneurons Shape Spatial Coding Alterations in Neurological Disord [PMID:40392508] Ikebara JM, Jorge RS, Marinho LSR, Higa Molecular neurobiology 2025 0
Somatostatin and the pathophysiology of Alzheimer's disease. [PMID:38484981] Almeida VN Ageing Res Rev 2024 0
P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667] Zhang D, Zhang W, Ming C, Gao X, Yuan H, Neuron 2024 0
The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117] Balusu S, De Strooper B Acta neuropathologica 2024 0

Debates (20)

Multi-agent debates referencing this entity

Structured research brief for hypothesis h-var-b7e4505525: Closed-loop transcran

closed · Rounds: 4 · Score: 0.63 · 2026-04-28

Extended debate: Closed-loop transcranial focused ultrasound with 40Hz gamma ent

closed · Rounds: 6 · Score: 0.95 · 2026-04-27

Extended debate: Closed-loop tACS targeting EC-II SST interneurons to block tau

closed · Rounds: 6 · Score: 0.95 · 2026-04-27

Debate: Closed-loop transcranial focused ultrasound targeting entorhinal PV inte

closed · Rounds: 4 · Score: 0.65 · 2026-04-27

Debate: Closed-loop tACS targeting EC-II SST interneurons to block tau propagati

closed · Rounds: 4 · Score: 0.71 · 2026-04-27

Debate: Closed-loop transcranial focused ultrasound to restore hippocampal gamma

closed · Rounds: 4 · Score: 0.87 · 2026-04-27

Debate: Closed-loop tACS targeting EC-II PV interneurons to suppress burst firin

closed · Rounds: 4 · Score: 0.48 · 2026-04-27

Debate: Closed-loop tACS targeting EC-II somatostatin interneurons to restore de

closed · Rounds: 4 · Score: 0.54 · 2026-04-27

Debate: Closed-loop transcranial focused ultrasound with real-time gamma feedbac

closed · Rounds: 4 · Score: 0.19 · 2026-04-27

Hypothesis debate: Closed-loop transcranial alternating current stimulation to r

closed · Rounds: 4 · Score: 0.40 · 2026-04-27

Related Research

Hypotheses and analyses mentioning SST in their description or question text

Hypothesis 7: SST-SST1R/Gamma Entrainment-Enhanced Astrocyte Secretome

Score: 0.839 · neurodegeneration · 2026-04-17

## Mechanistic Overview Hypothesis 7: SST-SST1R/Gamma Entrainment-Enhanced Astrocyte Secretome starts from the claim tha

Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST inter

Score: 0.827 · alzheimers · 2026-04-07

## Mechanistic Overview Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST interneurons to resto

Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activa

Score: 0.784 · alzheimers · 2026-04-05

## Mechanistic Overview Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activate AMPK-autophag

Alpha-gamma cross-frequency coupling enhancement to restore thalamo-cortical mem

Score: 0.775 · alzheimers · 2026-04-12

## Mechanistic Overview Alpha-gamma cross-frequency coupling enhancement to restore thalamo-cortical memory circuits sta

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Score: 0.767 · alzheimers · 2026-04-12

## Mechanistic Overview Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via somato

TREM2 Crosstalk and Synergistic Activation of Phagocytic Transcriptome

Score: 0.761 · neuroinflammation · 2026-04-22

**Molecular Mechanism and Rationale** The molecular mechanism underlying SPP1-TREM2 crosstalk centers on the synergisti

Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and r

Score: 0.752 · alzheimers · 2026-04-05

## Mechanistic Overview Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and restore perforant

Closed-loop focused ultrasound targeting EC-II SST interneurons to restore gamma

Score: 0.748 · alzheimers · 2026-04-05

## Mechanistic Overview Closed-loop focused ultrasound targeting EC-II SST interneurons to restore gamma gating and bloc

TREM2-ASM Crosstalk in Microglial Lysosomal Senescence

Score: 0.713 · neurodegeneration · 2026-04-12

## Mechanistic Overview TREM2-ASM Crosstalk in Microglial Lysosomal Senescence starts from the claim that modulating SMP

Vascular Cell Type Crosstalk Driving Blood-Brain Barrier Breakdown

Score: 0.662 · neurodegeneration · 2026-04-28

Pericyte-endothelial cross-talk failure leads to MMP9-mediated BBB disruption and tau propagation. Single-nucleus data r

Closed-loop transcranial alternating current stimulation to restore hippocampal-

Score: 0.603 · alzheimers · 2026-04-05

## Mechanistic Overview Closed-loop transcranial alternating current stimulation to restore hippocampal-prefrontal gamma

Cardiovascular-Neuroinflammation Crosstalk Interruption

Score: 0.587 · alzheimers · 2026-04-04

# Cardiovascular-Neuroinflammation Crosstalk Interruption: Targeting Shared Inflammatory Mediators in Neurodegeneratio

Optogenetic restoration of hippocampal gamma oscillations via selective SST inte

Score: 0.584 · alzheimers · 2026-04-07

## Mechanistic Overview Optogenetic restoration of hippocampal gamma oscillations via selective SST interneuron activati

Gamma Entrainment Synergy: HBOT-Enhanced Cerebral Perfusion Amplifies SST Intern

Score: 0.583 · neurodegeneration · 2026-04-17

## Mechanistic Overview Gamma Entrainment Synergy: HBOT-Enhanced Cerebral Perfusion Amplifies SST Interneuron-Targeted N