protein

BCL-2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BCL-2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1952Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

BCL-2 is a protein involved in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with ALS, Aging, Als. Connected to 1238 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	BCL
Pathways	Leukemia Cell Survival
GeneCards	BCL
Human Protein Atlas	BCL
Associated Diseases	ALS, Aging, Alzheimer, Cancer, Cardiomyopathy
Known Drugs/Compounds	Venetoclax, kaempferitrin, venetoclax, dasatinib, quercetin
Interactions	AMBRA1, AGO2, GENES, STAT3, SRC, TNF
KG Connections	1915 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    BCL_2["BCL-2"] -->|"promotes"| mitochondrial_outer_membrane_p["mitochondrial outer membrane permeabilization"]
    BCL_2["BCL-2"] -->|"regulates"| Fibrosis["Fibrosis"]
    BCL_2["BCL-2"] -->|"therapeutic target"| Als["Als"]
    BCL_2["BCL-2"] -->|"associated"| Lymphoma["Lymphoma"]
    BCL_2["BCL-2"] -.->|"inhibits"| Cancer["Cancer"]
    BCL_2["BCL-2"] -.->|"inhibits"| Als_1["Als"]
    DAG1["DAG1"] -->|"regulates"| BCL_2["BCL-2"]
    HSPG2["HSPG2"] -->|"regulates"| BCL_2["BCL-2"]
    FOXO1["FOXO1"] -->|"associated"| BCL_2["BCL-2"]
    BAX["BAX"] -->|"associated"| BCL_2["BCL-2"]
    style BCL_2 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1124)

Target	Relation	Type	Str
Als	therapeutic_target	disease	1.00
Cancer	inhibits	disease	1.00
Als	inhibits	disease	1.00
Apoptosis	inhibits	pathway	1.00
Cancer	activates	disease	1.00
Apoptosis	activates	pathway	1.00
Autophagy	activates	pathway	1.00
Als	regulates	disease	1.00
Apoptosis	associated_with	pathway	1.00
Tumor	inhibits	disease	1.00
Leukemia	therapeutic_target	disease	1.00
Als	activates	disease	1.00
Inflammation	activates	disease	1.00
Apoptosis	regulates	pathway	1.00
Inflammation	inhibits	disease	1.00
Tumor	activates	disease	1.00
Apoptosis	expressed_in	pathway	1.00
Oxidative Stress	activates	pathway	1.00
MTOR	activates	gene	1.00
Mtor	activates	pathway	1.00
AKT	activates	gene	1.00
AKT	therapeutic_target	gene	1.00
Cardiac	activates	disease	1.00
Neuroinflammation	activates	disease	1.00
Tumor	therapeutic_target	disease	1.00
Apoptosis	therapeutic_target	pathway	1.00
Lymphoma	regulates	disease	1.00
Cancer	therapeutic_target	disease	1.00
Lymphoma	therapeutic_target	disease	1.00
Tumor	expressed_in	disease	1.00
Als	associated_with	disease	1.00
Cancer	regulates	disease	1.00
Neurodegeneration	activates	disease	1.00
Carcinoma	therapeutic_target	disease	1.00
AUTOPHAGY	activates	gene	1.00
BRAIN INJURY	activates	gene	1.00
Drug Resistance	therapeutic_target	pathway	1.00
Pi3K/Akt	therapeutic_target	pathway	1.00
Pi3K/Akt	activates	pathway	1.00
DNA	activates	gene	1.00
MITOCHONDRIA	activates	gene	1.00
NRF2	activates	gene	1.00
P62	activates	gene	1.00
Nf-Κb	therapeutic_target	pathway	1.00
NEUROINFLAMMATION	activates	gene	1.00
Aging	activates	disease	0.95
Als	expressed_in	disease	0.95
Parkinson	activates	disease	0.95
Alzheimer	activates	disease	0.95
Cancer	expressed_in	disease	0.95

Incoming (828)

Source	Relation	Type	Str
BAX	expressed_in	gene	1.00
GENES	activates	gene	1.00
BAX	inhibits	gene	1.00
BAX	activates	gene	1.00
TNF	activates	gene	1.00
PI3K	activates	gene	1.00
PI3K	therapeutic_target	gene	1.00
AMPK	activates	gene	1.00
CANCER	therapeutic_target	gene	1.00
APOPTOSIS	therapeutic_target	gene	1.00
AUTOPHAGY	activates	gene	1.00
TNF-Α	activates	gene	1.00
APOPTOSIS	inhibits	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
APOPTOSIS	activates	gene	1.00
APOPTOSIS	regulates	gene	1.00
CANCER	activates	gene	1.00
BAX	regulates	gene	1.00
CANCER	inhibits	gene	1.00
APOPTOSIS	associated_with	gene	1.00
INFLAMMATION	inhibits	gene	1.00
NEURODEGENERATION	activates	gene	1.00
ROS	activates	gene	1.00
GENES	inhibits	gene	1.00
APOPTOSIS	expressed_in	gene	1.00
CYTOKINES	inhibits	gene	1.00
HO-1	activates	gene	1.00
STAT3	activates	gene	1.00
CANCER	regulates	gene	1.00
NEURODEGENERATIVE DISEASES	activates	gene	1.00
Venetoclax	inhibits	drug	0.95
T3	upregulates	drug	0.95
venetoclax	inhibits	drug	0.95
Venetoclax	targets	drug	0.90
TP53	binds_to	protein	0.90
PI3K	regulates	gene	0.90
PI3K	associated_with	gene	0.90
PI3K	inhibits	gene	0.90
TNF	inhibits	gene	0.90
GENES	therapeutic_target	gene	0.90
ASTROCYTES	activates	gene	0.90
PARKINSON'S DISEASE	activates	gene	0.90
P53	expressed_in	gene	0.90
P53	inhibits	gene	0.90
BCL2	activates	gene	0.90
ROS	regulates	gene	0.90
NF-ΚB	therapeutic_target	gene	0.90
GENES	expressed_in	gene	0.90
JAK2	upregulates	protein	0.88
kaempferitrin	inhibits	drug	0.85

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

BCL-2

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Alzheimer's Disease

NTF4 Protein

Growth Factor Therapies

rasagiline

Autophagy Mechanisms

VEGF/Angiogenesis Pathway in Neurodegeneration

Lithium for PSP/CBS — Phase 2 Trial

CREB Signaling in Neurodegeneration

Insulin Signaling in Parkinson's Disease

creatine-supplementation-neurodegeneration

Microglial Senescence Pathway in Neurodegeneration

Genistein for Mild Cognitive Impairment (NCT07385937)

FGF10 — Fibroblast Growth Factor 10

FOXO1 Protein

NF-kB Signaling Pathway in Neurodegeneration

Cellular Senescence in Neurodegeneration

tudca-udca-neurodegeneration