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concept

ALI

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALI: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

146Connections
30Hypotheses
0Analyses
0Outgoing
50Incoming
0Experiments
0Debates

Summary

ALI is a concept in neurodegeneration research. Key relationships include: implicated in, regulates, causes. Associated with SEPSIS. Connected to 146 entities in the SciDEX knowledge graph.

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💡 Concept Info
NameALI
Key Genes/ProteinsABCD3, ACTB, AGER, AKT, ALS, AMBRA1

Wiki Pages (1)

Knowledge base pages for this entity

OPALIN — Oligodendrocyte Myelin Membrane Protein

gene · 2228 words
→

Pathway Diagram

graph TD
    ALI["ALI"]
    S100A9["S100A9"] -->|"activates"| ALI
    SEPSIS["SEPSIS"] -->|"causes"| ALI
    CRH["CRH"] -->|"regulates"| ALI
    MAP1B["MAP1B"] -->|"implicated in"| ALI
    MAP2["MAP2"] -->|"implicated in"| ALI
    MAP6["MAP6"] -->|"implicated in"| ALI
    LIS1["LIS1"] -->|"implicated in"| ALI
    DCX["DCX"] -->|"implicated in"| ALI
    CD2AP["CD2AP"] -->|"implicated in"| ALI
    HCN1["HCN1"] -->|"implicated in"| ALI

Outgoing (0)

TargetRelationTypeStr
No outgoing edges

Incoming (146)

SourceRelationTypeStr
S100A9activatesprotein0.72
SEPSIScausesdisease0.72
CRHregulatesprotein0.64
MMP9associated_withprotein0.60
SMARCA4implicated_ingene0.50

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Activity-Dependent CD55/CD46 Trafficking and Synaptic Surfac 0.833 synaptic-biology What determines the selectivity of compl
IL-6 Trans-Signaling Blockade at the Oligodendrocyte-Microgl 0.831 neuroinflammation How do oligodendrocytes initiate neuroin
Microglial-Mediated Tau Clearance Dysfunction via TREM2 Sign 0.827 neuroscience Circuit-level neural dynamics in neurode
TREM2-Dependent Switch Hypothesis: TREM2 Agonism Redirects S 0.813 synaptic-biology Does SPP1-mediated synaptic engulfment r
CLU/APOE Duality in Amyloid Clearance Determines Cell-Type-S 0.811 neurodegeneration What are the cell-type-specific transcri
TIA1 Low-Complexity Domain Oxidation Drives Aberrant Stress 0.810 als -
Beta-Hydroxybutyrate Receptor (HCAR2) Signaling Links Ketone 0.808 neurodegeneration What are the precise temporal dynamics o
Hypothesis 1: MANF/CDNF Signaling as Primary Neuroprotective 0.798 neurodegeneration Which specific factors in conditioned me
CX3CR1-TREM2 Integration for Synapse Pruning Normalization 0.776 neurodegeneration TREM2 agonism vs antagonism in DAM micro
Direct Toxicity Hypothesis: β-Amyloid Directly Impairs Choli 0.769 - Do β-amyloid plaques and neurofibrillary
Selective LXRβ agonists restore ABCA1/ABCG1 expression and A 0.763 neuroscience APOE4-driven lipid metabolism dysregulat
Astrocyte C3aR Signaling as Bifurcation Point for A1/A2 Fate 0.749 alzheimers-disease-parkinsons -
TDP-43 condensation thermodynamics as a therapeutic target a 0.724 neuroscience How can subcellular compartmentalization
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides 0.718 neurodegeneration Blood-brain barrier transport mechanisms
Purinergic Signaling Polarization Control 0.713 neurodegeneration Astrocyte reactivity subtypes in neurode
LRRK2 kinase inhibition to normalize lysosomal trafficking i 0.710 neurodegeneration Test
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In 0.709 neurodegeneration Perivascular spaces and glymphatic clear
Blood Astrocyte-Derived Exosomal AQP4 Mislocalization Predic 0.685 - What blood-brain barrier permeability ch
Mitochondrial Quality Control Failure 0.680 neurodegeneration Cross-disease neurodegeneration mechanis
Gamma entrainment enhances TREM2-mediated microglial clearan 0.678 alzheimers Gamma entrainment therapy to restore hip
Gamma entrainment corrects AD-related clock gene dysregulati 0.676 alzheimers Gamma entrainment therapy to restore hip
Astrocytic-Mediated Tau Clearance Dysfunction via TREM2 Sign 0.672 neuroscience Circuit-level neural dynamics in neurode
Fyn-anchored dendritic tau/NMDAR signaling persists after tr 0.670 neurodegeneration Does tau dendritic missorting persist in
Leaky Gut LPS Translocation Activates Systemic TLR4/MyD88 Si 0.670 neurodegeneration How does gut microbiome dysbiosis contri
Dissociating SCFA's Dual Signaling Through GPR43/GPR41 Biase 0.670 neurodegeneration Do SCFAs directly modulate α-synuclein a
Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A 0.669 neurodegeneration What are the mechanisms by which gut mic
Chronic cGAS/STING Hyperactivation Drives Progressive Neurod 0.661 neuroinflammation How does chronic cGAS/STING activation d
Parthenolide reduces tonic ADORA2A signaling by lowering inf 0.659 neuropharmacology How does parthenolide specifically modul
EPO Set Point Calibration Hypothesis 0.653 endocrinology Does TRT-induced erythrocytosis actually
TBK1 Loss Triggers Astrocyte-to-Neuron Senescence Propagatio 0.000 als What are the mechanisms by which microgl

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Oligodendrocytes drive neuroinflammation and neurodegeneration in Parkinson's di [PMID:39913287] Ma Q, Tian JL, Lou Y, Guo R, Ma XR, Wu J Cell Rep 2025 1
Targeting Microglial Phagocytosis for Alzheimer's Disease Management: Natural, P [PMID:40641018] Raghuvanshi S, Mazumder A, Das S CNS & neurological disorders d 2026 0
Integrative Multiomics Insights into the Genetic and Epigenetic Architecture of [PMID:41422555] Mishra AK, Jain S ACS Chem Neurosci 2026 0
Peripheral cancer attenuates amyloid pathology in Alzheimer's disease via cystat [PMID:41576952] Li X, Tang X, Zeng J, Duan L, Hou Z et a Cell 2026 0
The association of Alzheimer's disease-related SNPs with mild cognitive impairme [PMID:41606232] Xie Z, Tu W, Ye XF, Hua L, Zhang X et al Sci Rep 2026 0
Genetic risk factors of late-onset Alzheimer's disease: Insights into pathophysi [PMID:41622452] Akkaoui J, Devadoss D, Rodriguez MD, Ari Neural Regen Res 2026 0
Genetic Burden and <i>APOE</i> Methylation in a Korean Multi-Generational Alzhei [PMID:41745359] Eom Je-Hyun; Cho Mu-Yeol; Kim Ji-Won; Ki Journal of personalized medici 2026 0
Genetic Architecture of Cognitive Resilience in Alzheimer's Disease: Mechanisms, [PMID:41893052] Burdman Gabriel; Akkaoui Juliet; Colon N Neurology international 2026 0
Posttraumatic stress disorder is associated with Alzheimer's disease-relevant mo [PMID:41960318] Seijo MA, Yohannes PA, Rogers AL, Gonzal Res Sq 2026 0
Genetic risk factors of late-onset Alzheimer's disease: Insights into pathophysi [PMID:41622452] Akkaoui J, Devadoss D, Rodriguez MD, Ari Neural regeneration research 2026 0
Genetic Architecture of Cognitive Resilience in Alzheimer's Disease: Mechanisms, [PMID:41893052] ["Burdman G", "Akkaoui J", "Colon N", "P Neurology international 2026 0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] ["Chen Kai", "Li Fuyao", "Zhang Shuwen", Journal of neuroinflammation 2025 0
The APOE-Microglia Axis in Alzheimer's Disease: Functional Divergence and Therap [PMID:40722268] Unknown Brain sciences 2025 0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] ["Chen Kai", "Li Fuyao", "Zhang Shuwen", Journal of neuroinflammation 2025 0
Axonal injury is a targetable driver of glioblastoma progression. [PMID:40836081] Clements M, Tang W, Florjanic Baronik Z, Nature 2025 0
Soluble CSF1R promotes microglial activation and amyloid clearance in alzheimer' [PMID:41152873] Zhang L, Chen K, Zeng R J Neuroinflammation 2025 0
Delivery of CDNF by AAV-mediated gene transfer protects dopamine neurons and reg [PMID:39019902] Nam J, Richie CT, Harvey BK Sci Rep 2024 0
α7nAChR activation in AT2 cells promotes alveolar regeneration through WNT7B sig [PMID:37410546] Unknown JCI Insight 2023 0
Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfuncti [PMID:36683512] Basha SC, Ramaiah MJ, Kosagisharaf JR J Alzheimers Dis 2023 0
CD38 in Neurodegeneration and Neuroinflammation. [PMID:32085567] Guerreiro S, Privat AL, Bressac L, Toulo Cells 2020 0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ALI in their description or question text

Beta-Hydroxybutyrate Receptor (HCAR2) Signaling Links Ketone Deficiency to Neuro

Score: 0.808 · neurodegeneration · 2026-04-15

## Mechanistic Overview Beta-Hydroxybutyrate Receptor (HCAR2) Signaling Links Ketone Deficiency to Neuroinflammation sta

Hypothesis 1: MANF/CDNF Signaling as Primary Neuroprotective Effector

Score: 0.798 · neurodegeneration · 2026-04-17

## Mechanistic Overview Hypothesis 1: MANF/CDNF Signaling as Primary Neuroprotective Effector starts from the claim that

CX3CR1-TREM2 Integration for Synapse Pruning Normalization

Score: 0.776 · neurodegeneration · 2026-04-16

## Mechanistic Overview CX3CR1-TREM2 Integration for Synapse Pruning Normalization starts from the claim that modulating

Direct Toxicity Hypothesis: β-Amyloid Directly Impairs Cholinergic Signaling

Score: 0.769 · unknown disease · 2026-04-12

## Mechanistic Overview Direct Toxicity Hypothesis: β-Amyloid Directly Impairs Cholinergic Signaling starts from the cla

Selective LXRβ agonists restore ABCA1/ABCG1 expression and APOE lipidation in AP

Score: 0.763 · neuroscience · 2026-04-22

**Molecular Mechanism and Rationale** The molecular basis for selective liver X receptor beta (LXRβ/NR1H2) agonism in A

TDP-43 condensation thermodynamics as a therapeutic target and biomarker for nuc

Score: 0.724 · neuroscience · 2026-04-26

FRAP-based measurement of TDP-43 liquid-liquid phase separation state provides a continuous biomarker of nuclear-cytopla

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides

Score: 0.718 · neurodegeneration · 2026-04-02

## Mechanistic Overview Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides starts from the claim that modulating

Purinergic Signaling Polarization Control

Score: 0.713 · neurodegeneration · 2026-04-02

## Mechanistic Overview Purinergic Signaling Polarization Control starts from the claim that modulating P2RY1 and P2RX7

LRRK2 kinase inhibition to normalize lysosomal trafficking in Parkinson's diseas

Score: 0.710 · neurodegeneration · 2026-05-01

LRRK2 G2019S mutations cause autosomal dominant PD through hyperactivation that impairs vesicular trafficking via Rab GT

Matrix Stiffness Normalization via Targeted Lysyl Oxidase Inhibition

Score: 0.709 · neurodegeneration · 2026-04-02

## **Molecular Mechanism and Rationale** The lysyl oxidase (LOX) family comprises six enzymes—LOX, LOXL1, LOXL2, LOXL3,

Blood Astrocyte-Derived Exosomal AQP4 Mislocalization Predicts Early Glymphatic

Score: 0.685 · unknown disease · 2026-04-26

Aquaporin-4 (AQP4) is normally highly polarized to astrocyte end-feet surrounding blood vessels, critical for glymphatic

Mitochondrial Quality Control Failure

Score: 0.680 · neurodegeneration · 2026-04-28

Impaired mitochondrial dynamics and reduced mitophagy represent a shared energy crisis converging on synaptic vulnerabil

Gamma entrainment enhances TREM2-mediated microglial clearance of Aβ plaques via

Score: 0.678 · alzheimers · 2026-04-28

40 Hz neural activity induces Ca2+ oscillations in microglia through P2X7 receptor activation, promoting TREM2 phosphory
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