protein

DRP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DRP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1722Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

DRP1 is a protein involved in neurodegeneration research. Key relationships include: interacts with, activates, regulates. Associated with AD, ALI, ALS. Connected to 777 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	DRP1
Protein Type	Enzyme
Function	The DRP1 gene encodes a 736-amino acid GTPase
Pathways	Apoptosis, Autophagy, Cell Cycle, Complement, Dna Methylation
Ensembl ID	ENSG00000141971
GeneCards	DRP1
Human Protein Atlas	DRP1
Mitochondrial fission	Mediates scission of mitochondrial outer membrane
GTP hydrolysis	Self-assembles into rings that hydrolyze GTP to drive membrane constriction
Associated Diseases	AD, ALI, ALS, Aging, Alzheimer
Known Drugs/Compounds	propionic acid, ginsenoside Re, Zuo Gui Wan, Rg1, Mdivi-1, Palmitic Acid
Interactions	CHOP, BECN1, PTEN, DDIT3, NBR1, EMD
KG Connections	1718 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    DRP1(["DRP1"])
    MITOPHAGY(["MITOPHAGY"])
    Mitophagy["Mitophagy"]
    Als["Als"]
    Cancer["Cancer"]
    Mitochondrial_Derived_Vesicle_Biogenesis("Mitochondrial-Derived Vesicle Bi...")
    MITOCHONDRIAL_DERIVED_VESICLES["MITOCHONDRIAL-DERIVED VESICLES"]
    DNA(["DNA"])
    Mitochondrial_Function["Mitochondrial Function"]
    MITOCHONDRIA(["MITOCHONDRIA"])
    MITOCHONDRIAL_DNA(["MITOCHONDRIAL DNA"])
    Neurodegeneration["Neurodegeneration"]
    Autophagy["Autophagy"]
    Apoptosis["Apoptosis"]

    MITOPHAGY -->|"activates"| DRP1
    DRP1 -->|"activates"| Mitophagy
    DRP1 -->|"activates"| Als
    DRP1 -->|"activates"| Cancer
    DRP1 -->|"mediates"| Mitochondrial_Derived_Vesicle_Biogenesis
    DRP1 -->|"regulates"| MITOCHONDRIAL_DERIVED_VESICLES
    DRP1 -->|"regulates"| Mitophagy
    DRP1 -->|"activates"| DNA
    DRP1 -.->|"inhibits"| Mitochondrial_Function
    DRP1 -->|"activates"| MITOCHONDRIA
    MITOPHAGY -->|"regulates"| DRP1
    MITOCHONDRIAL_DNA -->|"activates"| DRP1
    DRP1 -->|"implicated in"| Neurodegeneration
    DRP1 -->|"activates"| Autophagy
    DRP1 -->|"activates"| Apoptosis

    style DRP1 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (1099)

Target	Relation	Type	Str
Mitophagy	activates	pathway	1.00
MITOCHONDRIAL-DERIVED VESICLES	regulates	entity	0.95
Purkinje Cell Apoptosis	regulates	process	0.95
mitochondrial-derived vesicle biogenesis	drives	process	0.95
Mitochondrial Fragmentation	activates	process	0.95
Als	activates	disease	0.95
Cancer	activates	disease	0.95
Mitochondrial Dysfunction	regulates	process	0.95
Mitochondrial-Derived Vesicle Biogenesis	mediates	process	0.95
Mitochondrial-Derived Vesicle Biogenesis	activates	process	0.95
Mitochondrial Fragmentation	mediates	process	0.95
Serine 616	phosphorylates	biomarker	0.95
Mitochondrial-Derived Vesicle Biogenesis	promotes	process	0.95
Membrane Scission	mediates	process	0.95
Mitochondrial Dynamics	involved_in	process	0.95
Axonal Degeneration	mediates	process	0.92
Neuronal Degeneration	involved_in	phenotype	0.91
Cerebellar Ataxia	associated_with	disease	0.90
mitochondrial dynamics	participates_in	pathway	0.90
Retinal Ganglion Neuron Degeneration	protects_against	phenotype	0.90
oxidative stress response	participates_in	pathway	0.90
Mitochondrial Fission	mediates	process	0.90
Mitochondrial Fission	promotes	process	0.90
Mitochondrial Dynamics	regulates	process	0.90
Mitophagy	regulates	pathway	0.90
DNA	activates	gene	0.90
Mitochondrial Function	inhibits	pathway	0.90
MITOCHONDRIA	activates	gene	0.90
Tumor Growth	contributes_to	phenotype	0.85
Neuronal Cell Death	mediates	phenotype	0.85
mitochondrial fragmentation	mediates	phenotype	0.85
Mitochondrial Fission	regulates	process	0.85
Neurodegeneration	implicated_in	disease	0.85
Tumor Growth	mediates	phenotype	0.85
Parkinson's disease	involved_in	disease	0.85
Alzheimer's Disease	biomarker_for	disease	0.85
Axotomy	targets	process	0.80
Purkinje cells	regulates	cell_type	0.80
Purkinje cells	causes	cell_type	0.80
mitochondrial function	participates_in	pathway	0.80
Chemotherapy-induced peripheral neuropathy	involved_in	disease	0.80
vascular leakage	drives	phenotype	0.80
mitochondrial dynamics	mediates	biological_process	0.80
Mitochondrial Dysfunction	involved_in	phenotype	0.80
Autophagy	activates	pathway	0.80
Apoptosis	activates	pathway	0.80
Apoptosis	regulates	pathway	0.80
MITOCHONDRIA	regulates	gene	0.80
Oxidative Stress	regulates	pathway	0.80
NEURON	activates	gene	0.80

Incoming (623)

Source	Relation	Type	Str
MITOPHAGY	activates	gene	1.00
Rg1	inhibits	compound	0.95
Mdivi-1	inhibits	drug	0.95
PGAM5	promotes	protein	0.95
DIZE	upregulates	drug	0.90
DLK	phosphorylates	protein	0.90
ataluren	associated_with	drug	0.90
Paclitaxel	upregulates	drug	0.90
MAPK	phosphorylates	pathway	0.90
MITOPHAGY	regulates	gene	0.90
MITOCHONDRIAL DNA	activates	gene	0.90
MAP3K12	phosphorylates	gene	0.85
PM10	upregulates	compound	0.85
Palmitic Acid	phosphorylates	compound	0.85
GJA1-20k	modulates	protein	0.85
endothelial cell	expressed_in	cell_type	0.85
Aging	upregulates	process	0.85
AMYLOID-BETA	upregulates	protein	0.85
E2F1	regulates	gene	0.80
MIROS	drives	protein	0.80
MTOR	modulates	protein	0.80
Onconase	downregulates	drug	0.80
Palmitic Acid	modulates	compound	0.80
PINK1	activates	gene	0.80
OPA1	activates	gene	0.80
APOPTOSIS	regulates	gene	0.80
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.80
AUTOPHAGY	activates	gene	0.80
OXIDATIVE STRESS	regulates	gene	0.80
CANCER	activates	gene	0.80
NEURODEGENERATION	implicated_in	gene	0.80
GJA1-20k	associated_with	protein	0.75
PGAM5	regulates	protein	0.72
DNM1L	interacts_with	gene	0.70
LC3	interacts_with	gene	0.70
PINK1	associated_with	gene	0.70
FUNDC1	interacts_with	gene	0.70
LC3	activates	gene	0.70
PINK1	regulates	gene	0.70
CLDN5	inhibits	gene	0.70
CLDN5	protects_against	gene	0.70
APOE4	activates	protein	0.70
Copper	activates	drug	0.70
LC3B	interacts_with	gene	0.70
GENES	activates	gene	0.70
AMPK	activates	gene	0.70
PARKINSON'S DISEASE	inhibits	gene	0.70
MITOPHAGY	interacts_with	gene	0.70
RAS	activates	gene	0.70
GENES	regulates	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Mitochondrial transfer between astrocytes and neurons

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.570

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DRP1

Understanding Entity Pages

Summary

Wiki Pages (21)

DRP1 Gene - Dynamin 1-Like Protein

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Novel Therapy Index

NRF2 Oxidative Stress Pathway

Mitochondrial Quality Control

Mitochondrial Dysfunction in Parkinson's Disease

Autophagy Mechanisms

Mitophagy Pathway in Neurodegeneration

Coenzyme Q10 for Neurodegeneration

nf1-protein

Mitochondrial Dysfunction in Neurodegeneration

Copper Dyshomeostasis in Neurodegeneration

Insulin Signaling in Parkinson's Disease

Neuroinflammation-Mitochondria Crosstalk Pathway

Peroxisome Pathway in Neurodegeneration

Motor Neuron Disease (MND)

mitochondrial-dynamics-dysfunction-parkinsons

DDX3X Gene

Mitochondria

Chaperone-Mediated Autophagy in Neurodegeneration