concept

SESTRIN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SESTRIN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

179Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	SESTRIN2
Key Genes/Proteins	ULK1, P62, mTORC1, XBP1, SQSTM1, p62/sequestosome-1
Related Diseases	Alzheimer, Cardiovascular, Parkinson

Wiki Pages (7)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    SESTRIN2["SESTRIN2"]
    style SESTRIN2 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    SESTRIN2 -->|"interacts"| ULK1([ULK1])
    SESTRIN2 -->|"interacts"| P62([P62])
    SESTRIN2 -.->|"inhibits"| mTORC1([mTORC1])
    SESTRIN2 -->|"regulates"| Autophagy["Autophagy"]
    SESTRIN2 -->|"interacts"| SQSTM1([SQSTM1])
    SESTRIN2 -->|"interacts"| Alzheimer["Alzheimer"]
    SESTRIN2 -->|"interacts"| Cardiovascular["Cardiovascular"]
    SESTRIN2 -->|"interacts"| Parkinson["Parkinson"]
    XBP1([XBP1]) -->|"upregulates"| SESTRIN2
    ULK1 -->|"phosphorylates"| SESTRIN2
    LC3([LC3]) -->|"interacts"| SESTRIN2
    CALCOCO2([CALCOCO2]) -->|"interacts"| SESTRIN2
    CATALASE([CATALASE]) -->|"interacts"| SESTRIN2
    PRESENILIN([PRESENILIN]) -->|"interacts"| SESTRIN2
    BNIP3L([BNIP3L]) -->|"interacts"| SESTRIN2
    MITOCHONDRIA([MITOCHONDRIA]) -->|"interacts"| SESTRIN2
    NLR([NLR]) -->|"interacts"| SESTRIN2
    MFN1([MFN1]) -->|"interacts"| SESTRIN2

Outgoing (102)

Target	Relation	Type	Str
ULK1	interacts_with	protein	0.95
P62	interacts_with	protein	0.95
mTORC1	inhibits	protein	0.95
Autophagy	regulates	process	0.93
ULK1	modulates	protein	0.92
SQSTM1	interacts_with	protein	0.90
Protein Aggregate Degradation	associated_with	process	0.88
Autophagy	activates	process	0.85
p62/sequestosome-1	promotes	protein	0.80
Unc-51-like kinase 1	promotes	protein	0.80
Alzheimer	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Obesity	regulates	disease	0.65
Als	interacts_with	disease	0.65
ROS	interacts_with	gene	0.60
EIF2S1	interacts_with	gene	0.60
LC3B	interacts_with	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
HIF	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
RHOT1	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
RTN3	interacts_with	gene	0.60
RETREG1	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
NUCLEOPHAGY	interacts_with	gene	0.60
SESN2	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
NIX	interacts_with	gene	0.60
ABCD3	interacts_with	gene	0.60
HIF1	interacts_with	gene	0.60
FAM134B	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
FUNDC1	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60

Incoming (77)

Source	Relation	Type	Str
XBP1	upregulates	protein	0.92
ULK1	phosphorylates	protein	0.85
LC3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
CATALASE	interacts_with	gene	0.60
PRESENILIN	interacts_with	gene	0.60
BNIP3L	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
PERK	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
RIPK3	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
BNIP3	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BIM	interacts_with	gene	0.60
PARL	interacts_with	gene	0.60
RIP3	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
BCL2L11	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
JNK	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
CHOP	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
NRF2	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SESTRIN2

Understanding Entity Pages

Wiki Pages (7)

SESN2 Gene

Sestrin Signaling Pathway in Neurodegeneration

SESN2 Protein

mTOR (Mammalian Target of Rapamycin) Neurons

SESN1 Protein