PDPK1

Understanding Entity Pages

This page aggregates everything SciDEX knows about PDPK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

3-Phosphoinositide Dependent Protein Kinase 1 - master activator of AKT signaling in neuronal survival and neurodegeneration

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graph TD
    PDPK1["<b>PDPK1</b>"]
    AKT["AKT"]
    PDPK1 -->|"activates"| AKT
    RSK2["RSK2"]
    PDPK1 -->|"activates"| RSK2
    FasL["FasL"]
    PDPK1 -->|"activates"| FasL
    SDC2["SDC2"]
    PDPK1 -->|"binds"| SDC2
    miR_1183["miR-1183"]
    PDPK1 -->|"regulates"| miR_1183
    HOTAIR["HOTAIR"]
    PDPK1 -->|"regulates"| HOTAIR
    S6K["S6K"]
    PDPK1 -->|"activates"| S6K
    DNMT1["DNMT1"]
    PDPK1 -->|"regulates"| DNMT1
    Ms{"Ms"}
    PDPK1 -->|"expressed in"| Ms
    Schizophrenia{"Schizophrenia"}
    PDPK1 -->|"expressed in"| Schizophrenia
    PIK3C3["PIK3C3"]
    PDPK1 -->|"associated with"| PIK3C3
    LC3["LC3"]
    PDPK1 -->|"associated with"| LC3
    BCL2["BCL2"]
    BCL2 -->|"associated with"| PDPK1
    ATG14["ATG14"]
    ATG14 -->|"associated with"| PDPK1
    MTOR["MTOR"]
    MTOR -->|"associated with"| PDPK1
    MAP1LC3["MAP1LC3"]
    MAP1LC3 -->|"associated with"| PDPK1
    BECN1["BECN1"]
    BECN1 -->|"associated with"| PDPK1
    SQSTM1["SQSTM1"]
    SQSTM1 -->|"associated with"| PDPK1
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"associated with"| PDPK1
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"associated with"| PDPK1
    FOXO1["FOXO1"]
    FOXO1 -->|"expressed in"| PDPK1
    AKT -->|"activates"| PDPK1
    AKT1["AKT1"]
    AKT1 -->|"expressed in"| PDPK1
    style PDPK1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0