protein

CATALASE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CATALASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

607Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Comprehensive page on Catalase - structure, function, role in oxidative stress and neurodegenerative diseases, and therapeutic potential

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🔬 Protein Info

Gene Symbol	CATALASE
Aliases	Comprehensive page on Catalase
Chromosome	11q13.1.
Primary Expression	Cortex, Hippocampus
Subcellular Localization	to peroxisomes in astrocytes and neurons, where it serves as a critical componen
Molecular Weight	60 kDa
Pathways	Autophagy, Mitophagy, Cell Cycle, Mapk, Apoptosis
GeneCards	CATALASE
Human Protein Atlas	CATALASE
Associated Diseases	cancer, oxidative stress
Known Drugs/Compounds	NICOTINAMIDE
Interactions	ROS, UBIQUITIN, PARKIN, SQSTM1, PINK1, RIPK3
KG Connections	601 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CATALASE["CATALASE"]
    CATALASE -->|"inhibits"| Oxidative_Stress["Oxidative Stress"]
    CATALASE -->|"treats"| Parkinson_s_disease["Parkinson's disease"]
    CATALASE -->|"expressed in"| Neuronal_cells["Neuronal cells"]
    CATALASE -->|"activates"| AKT["AKT"]
    CATALASE -->|"activates"| GBM["GBM"]
    CATALASE -->|"activates"| HIF_1_["HIF-1Alpha"]
    CATALASE -->|"activates"| PI3K["PI3K"]
    NRF2["NRF2"] -->|"regulates"| CATALASE
    Exosomes["Exosomes"] -->|"interacts"| CATALASE
    ALS["ALS"] -->|"activates"| CATALASE
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| CATALASE
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| CATALASE
    APOPTOSIS["APOPTOSIS"] -->|"activates"| CATALASE
    BECN1["BECN1"] -->|"activates"| CATALASE
    AMPK["AMPK"] -->|"activates"| CATALASE

Outgoing (396)

Target	Relation	Type	Str
Alzheimer	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
ALS	regulates	disease	0.65
Als	interacts_with	disease	0.65
Als	therapeutic_target	disease	0.65
Ferroptosis	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Senescence	inhibits	disease	0.65
Cancer	interacts_with	disease	0.65
Parkinson	activates	disease	0.65
Als	expressed_in	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	biomarker_for	disease	0.65
Alzheimer	activates	disease	0.65
Als	inhibits	disease	0.65
Aging	interacts_with	disease	0.65
Als	activates	disease	0.65
Dementia	activates	disease	0.65
Pyroptosis	activates	disease	0.65
Tumor	degrades	disease	0.65
Inflammation	activates	disease	0.65
Tumor	expressed_in	disease	0.65
Cancer	regulates	disease	0.65
ALS	expressed_in	disease	0.65
ALS	biomarker_for	disease	0.65
Tumor	activates	disease	0.65
Aging	activates	disease	0.65
Glioblastoma	activates	disease	0.65
ALS	inhibits	disease	0.65
PRESENILIN	interacts_with	gene	0.60
BNIP3L	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
PERK	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
RIPK3	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60

Incoming (211)

Source	Relation	Type	Str
NRF2	upregulates	protein	0.90
NRF2	regulates	protein	0.72
LC3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
PARL	interacts_with	gene	0.60
BNIP3	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
PRESENILIN	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
FUNDC1	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
PHB2	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
ABCD3	interacts_with	gene	0.60
NUCLEOPHAGY	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
SESTRIN2	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
SESN2	interacts_with	gene	0.60
GSH	associated_with	gene	0.60
NRF2	inhibits	gene	0.60
JNK	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
C-JUN	inhibits	gene	0.60
RNA	inhibits	gene	0.60
FERROPTOSIS	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CATALASE

Understanding Entity Pages

Summary

Wiki Pages (21)

Catalase Protein

Progressive Supranuclear Palsy (PSP)

CBS/PSP Supplements Guide

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

NRF2 Oxidative Stress Pathway

NTF4 Protein

oxidative-stress-comparison

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

Sulforaphane and Nrf2 Activation for Neuroprotection

dimethyl-fumarate-nrf2-ad-nct06850597

NACET (N-Acetylcysteine Ethyl Ester)

Neuroinflammation-Mitochondria Crosstalk Pathway

NDUFAF3 Gene

Peroxisome Pathway in Neurodegeneration

Lipid Peroxidation in Neurodegeneration

Genistein for Mild Cognitive Impairment (NCT07385937)

FGF10 — Fibroblast Growth Factor 10

FOXO1 Protein

Peroxisomal Dysfunction