disease

NAFLD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NAFLD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

463Connections

0Hypotheses

0Analyses

49Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	NUP85, PPAR, SQSTM1, SIRT3, BECN1, LAMP2, FOXO1, PPARA
Therapeutic Agents	SCHISANHENOL, hesperetin, gastrodin, Hesperetin, Pterostilbene, Postbiotics
KG Connections	206 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (15)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    NAFLD["NAFLD"] -->|"increases risk"| Atherosclerotic_Cardiovascular["Atherosclerotic Cardiovascular Disease"]
    style Atherosclerotic_Cardiovascular fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    NAFLD["NAFLD"] -->|"associated"| METABOLIC_SYNDROME["METABOLIC_SYNDROME"]
    style METABOLIC_SYNDROME fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    NAFLD["NAFLD"] -->|"contributes to"| STEATOHEPATITIS["STEATOHEPATITIS"]
    style STEATOHEPATITIS fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    NAFLD["NAFLD"] -->|"activates"| CIRRHOSIS["CIRRHOSIS"]
    style CIRRHOSIS fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    NAFLD["NAFLD"] -->|"implicated in"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    style OXIDATIVE_STRESS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    NAFLD["NAFLD"] -->|"associated"| RNA_SPLICING["RNA SPLICING"]
    style RNA_SPLICING fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    NAFLD["NAFLD"] -.->|"inhibits"| OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"]
    style OXIDATIVE_PHOSPHORYLATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    hesperetin["hesperetin"] -->|"treats"| NAFLD["NAFLD"]
    style hesperetin fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    NUP85["NUP85"] -->|"associated"| NAFLD["NAFLD"]
    style NUP85 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Triglyceride_Accumulation["Triglyceride Accumulation"] -->|"causes"| NAFLD["NAFLD"]
    style Triglyceride_Accumulation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    gastrodin["gastrodin"] -->|"treats"| NAFLD["NAFLD"]
    style gastrodin fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    AMPK["AMPK"] -->|"protects against"| NAFLD["NAFLD"]
    style AMPK fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    style NAFLD fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (141)

Target	Relation	Type	Str
Chronic Liver Disease	contributes_to	disease	0.85
Atherosclerotic Cardiovascular Disease	increases_risk	disease	0.80
METABOLIC_SYNDROME	associated_with	disease	0.72
AMPK	targets	gene	0.65
AMPK	phosphorylates	gene	0.65
EGF	regulates	gene	0.65
STEATOHEPATITIS	contributes_to	disease	0.64
CIRRHOSIS	activates	disease	0.56
OXIDATIVE STRESS	implicated_in	process	0.50
Rna Splicing	regulates	gene	0.50
Proteins	associated_with	protein	0.50
ENDOTHELIAL CELLS	activates	concept	0.50
ENDOPLASMIC RETICULUM	activates	concept	0.50
INSULIN	associated_with	concept	0.50
ENDOPLASMIC RETICULUM STRESS	associated_with	concept	0.50
ENDOPLASMIC RETICULUM	associated_with	concept	0.50
HEPATOCYTES	associated_with	concept	0.50
Dysbiosis	regulates	disease	0.50
Gut Microbiota	regulates	process	0.50
APOE	associated_with	gene	0.50
INSR	associated_with	gene	0.50
AMPK	associated_with	gene	0.45
MTOR	associated_with	gene	0.45
CCL2	associated_with	gene	0.45
PI3K	associated_with	gene	0.45
EGFR	associated_with	gene	0.45
AKT	associated_with	gene	0.45
EGF	associated_with	gene	0.45
TFEB	associated_with	gene	0.45
ULK1	associated_with	gene	0.45
TP53	associated_with	gene	0.45
CREB	associated_with	gene	0.45
RNA SPLICING	associated_with	process	0.35
OXIDATIVE PHOSPHORYLATION	inhibits	process	0.35
ULK1	expressed_in	gene	0.35
PHAGOCYTOSIS	activates	process	0.35
RAPAMYCIN	activates	drug	0.35
SQSTM1	activates	gene	0.35
SIRT1	activates	gene	0.35
SIRT3	activates	gene	0.35
TP53	activates	gene	0.35
TFEB	activates	gene	0.35
P62	activates	gene	0.35
P53	activates	gene	0.35
RAS	activates	gene	0.35
PI3K/AKT SIGNALING	regulates	process	0.35
OBESITY	interacts_with	disease	0.35
SIRT1	regulates	gene	0.35
NLRP3	regulates	gene	0.35

Incoming (322)

Source	Relation	Type	Str
NUP85	involved_in	gene	0.95
Pterostilbene	treats	compound	0.95
hesperetin	treats	drug	0.90
NUP85	associated_with	protein	0.90
Triglyceride Accumulation	causes	phenotype	0.90
DRAK2	aggravates	gene	0.90
gastrodin	treats	drug	0.85
AMPK	protects_against	protein	0.80
AMPK	therapeutic_target	pathway	0.80
PI3K/AKT Signaling Pathway	involved_in	pathway	0.80
Mitochondrial Impairment	contributes_to	phenotype	0.80
Postbiotics	treats	compound	0.80
NF-κB	therapeutic_target	pathway	0.75
SCHISANHENOL	treats	drug	0.72
AUTOPHAGY	associated_with	pathway	0.72
Hesperetin	treats	drug	0.70
APOPTOSIS	regulates	phenotype	0.65
LIPOGENESIS	causes	phenotype	0.65
LIPOTOXICITY	causes	phenotype	0.64
APOPTOSIS	expressed_in	phenotype	0.55
HEPATOCYTES	activates	cell_type	0.50
FIBROSIS	activates	disease	0.50
MICRORNA REGULATION	activates	process	0.50
CIRRHOSIS	associated_with	disease	0.50
AMPK	regulates	gene	0.50
disease	associated_with	disease	0.50
apoptosis	activates	process	0.50
Metabolic Syndrome	interacts_with	disease	0.50
disease	interacts_with	disease	0.50
Fatty Liver	interacts_with	disease	0.50
Cirrhosis	associated_with	disease	0.50
FIBROSIS	associated_with	disease	0.50
Fatty Liver	associated_with	disease	0.50
DIABETES	causes	disease	0.50
OBESITY	causes	disease	0.50
AMPK	activates	protein	0.50
Microrna	activates	pathway	0.50
PRKAB1	inhibits	gene	0.50
AMPK	inhibits	protein	0.50
disease	activates	disease	0.50
CELL DEATH	activates	concept	0.50
Fatty Liver	activates	disease	0.50
CARCINOMA	associated_with	disease	0.50
mTOR	regulates	entity	0.50
CYP3A4	regulates	gene	0.50
CYP1A2	regulates	concept	0.50
CCL2	activates	protein	0.50
Cirrhosis	activates	disease	0.50
Pi3K	activates	pathway	0.50
ERCC3	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NAFLD

Understanding Entity Pages

Wiki Pages (15)

GPT - Alanine Transaminase (ALT)

Liver-Brain Neurodegeneration Axis

SPART — Spartin

CIDEA — Cell Death-Inducing DFFA-Like Effector A

CIDEC Gene

VPS4A — Vacuolar Protein Sorting 4 Homolog A

Kupffer Cells

NLRP6 Protein (NACHT, LRR and PYD Domains-Containing Protein 6)

CIDEB — Cell Death-Inducing DFFA-Like Effector B

FGF19 — Fibroblast Growth Factor 19

GPR146 — G Protein-Coupled Receptor 146

APOC3 Gene

NQO2 (NAD(P)H Quinone Dehydrogenase 2)