gene

PRKAA2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRKAA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

241Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

PRKAA2 (AMPKα2) — AMP-Activated Protein Kinase Catalytic Subunit Alpha 2

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🧬 Gene Info

Gene Symbol	PRKAA2
Full Name	Protein Kinase AMP-Activated Catalytic Subunit Alpha 2
Aliases	AMP-Activated Protein Kinase Catalytic Subunit Alpha 2
Chromosome	1p32.2
Protein Type	Serine/Threonine Kinase
Function	is a convergent pathomechanism across major neurodegenerative diseases, making PRKAA2 a high-priority therapeutic target.
Primary Expression	oligodendrocytes
Amino Acids	552 aa
Exons	12
Pathways	Autophagy, autophagy pathway, complement cascade, oxidative stress response, phagocytosis
Ensembl ID	ENSG00000162409
GeneCards	PRKAA2
Human Protein Atlas	PRKAA2
Associated Diseases	Alzheimer Disease, Neurodegeneration
Known Drugs/Compounds	Metformin, AICAR, rapamycin, metformin
Interactions	LAMP2, PLIN3, BECN1, GRK2, FOXO1, NR1H3
KG Connections	240 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (14)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PRKAA2["PRKAA2"] -->|"interacts"| Tumor["Tumor"]
    PRKAA2["PRKAA2"] -->|"interacts"| Hepatitis["Hepatitis"]
    PRKAA2["PRKAA2"] -->|"activates"| Als["Als"]
    PRKAA2["PRKAA2"] -->|"activates"| Ms["Ms"]
    PRKAA2["PRKAA2"] -->|"interacts"| Ischemia["Ischemia"]
    PRKAA2["PRKAA2"] -->|"interacts"| Inflammation["Inflammation"]
    PPARA["PPARA"] -->|"interacts"| PRKAA2["PRKAA2"]
    ULK1["ULK1"] -->|"interacts"| PRKAA2["PRKAA2"]
    STX17["STX17"] -->|"interacts"| PRKAA2["PRKAA2"]
    SQSTM1["SQSTM1"] -->|"interacts"| PRKAA2["PRKAA2"]
    style PRKAA2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (126)

Target	Relation	Type	Str
protein synthesis	inhibits	process	0.95
Protein Synthesis	inhibits	process	0.95
Amino Acid Insufficiency	mediates	phenotype	0.95
Metformin	therapeutic_target	drug	0.90
Alzheimer Disease	associated_with	disease	0.90
Protein Aggregation	regulates	process	0.90
Alzheimer Disease	protects_against	disease	0.90
PPARGC1A	activates	gene	0.85
cognitive dysfunction	protects_against	phenotype	0.80
MTORC1	inhibits	protein	0.80
Alzheimer's Disease	protects_against	disease	0.80
zonula occludens-1	upregulates	protein	0.75
Tumor	interacts_with	disease	0.65
Hepatitis	interacts_with	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
Ischemia	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Fatty Liver	activates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
ALS	activates	disease	0.65
LAMP2	interacts_with	gene	0.60
PLIN3	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
GRK2	interacts_with	gene	0.60
FOXO1	interacts_with	gene	0.60
NR1H3	interacts_with	gene	0.60
MAP3K5	interacts_with	gene	0.60
SREBF2	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
C1Q	interacts_with	gene	0.60
HTRA2	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
SIRT3	interacts_with	gene	0.60
PLIN2	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
KDM6B	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
STX17	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
GLP1R	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
NOS3	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
SIRT1	therapeutic_target	gene	0.60
TFEB	activates	gene	0.60
EIF2A	expressed_in	gene	0.60
RPTOR	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
PPARA	interacts_with	gene	0.60

Incoming (115)

Source	Relation	Type	Str
Amino Acid Insufficiency	activates	phenotype	0.95
GCN2	phosphorylates	gene	0.90
SESN1	activates	gene	0.85
AICAR	activates	compound	0.85
Metformin	activates	drug	0.85
metformin	activates	drug	0.85
protein restriction	activates	process	0.75
PPARA	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
STX17	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
NOS3	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
GLP1R	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
KDM6B	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
FOXO1	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
NR1H3	interacts_with	gene	0.60
MAP3K5	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
HTRA2	interacts_with	gene	0.60
TFEB	activates	gene	0.60
SLC22A4	expressed_in	gene	0.60
TLR4	expressed_in	gene	0.60
EPHA4	expressed_in	gene	0.60
PLIN3	interacts_with	gene	0.60
PLIN2	interacts_with	gene	0.60
C1Q	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
SIRT3	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
SIRT1	therapeutic_target	gene	0.60
BECN1	activates	entity	0.60
C1Q	activates	entity	0.60
FOXO1	activates	entity	0.60
GLP1R	activates	entity	0.60
GRK2	activates	entity	0.60
HTRA2	activates	entity	0.60
KDM6B	activates	entity	0.60
LAMP2	activates	entity	0.60
LC3	activates	entity	0.60
MAP3K5	activates	entity	0.60
MTOR	activates	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PRKAA2

Understanding Entity Pages

Summary

Wiki Pages (14)

PRKAA2 (AMPKα2) — AMP-Activated Protein Kinase Catalytic Subunit Alpha 2

Protein Synthesis in Neurodegenerative Diseases

MARK Tau Phosphorylation Pathway - Microtubule Affinity Regulating Kinase

PRKAB1 — Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1

AMPK Signaling in Parkinson's Disease

AMPK Protein

PRKAA1

AMPK-Mitochondrial Quality Control Axis

STK3

LATS2

AMPK (AMP-Activated Protein Kinase)

KDM6B (JMJD3)