concept

DENTATE GYRUS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DENTATE GYRUS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

200Connections

0Hypotheses

0Analyses

50Outgoing

39Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	DENTATE GYRUS
Key Genes/Proteins	TAU, APP, AMYLOID-BETA
Related Diseases	NEUROGENESIS, SYNAPTIC PLASTICITY, ALZHEIMER'S DISEASE, AGING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    DENTATE_GYRUS["DENTATE GYRUS"]
    DENTATE_GYRUS -->|"involved_in"| Cognition["Cognition"]
    DENTATE_GYRUS -->|"expressed in"| adult_neurogenesis["adult neurogenesis"]
    DENTATE_GYRUS -->|"inhibits"| NEUROGENESIS["NEUROGENESIS"]
    DENTATE_GYRUS -->|"inhibits"| NEURON["NEURON"]
    DENTATE_GYRUS -->|"inhibits"| STING["STING"]
    DENTATE_GYRUS -->|"regulates"| INTERNEURON["INTERNEURON"]
    DENTATE_GYRUS -->|"expressed in"| HIPPOCAMPUS["HIPPOCAMPUS"]
    APOPTOSIS["APOPTOSIS"] -->|"inhibits"| DENTATE_GYRUS
    ANXIETY["ANXIETY"] -->|"causes"| DENTATE_GYRUS
    AMYLOID["AMYLOID"] -->|"activates"| DENTATE_GYRUS
    ALZHEIMER["ALZHEIMER"] -->|"impairs"| DENTATE_GYRUS
    ALZHEIMER_S["ALZHEIMER'S"] -->|"impairs"| DENTATE_GYRUS
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"impairs"| DENTATE_GYRUS
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"expressed in"| DENTATE_GYRUS
    COMPLEMENT["COMPLEMENT"] -->|"expressed in"| DENTATE_GYRUS

Outgoing (58)

Target	Relation	Type	Str
NEUROGENESIS	regulates	phenotype	0.70
SYNAPTIC PLASTICITY	activates	phenotype	0.70
NEURON	inhibits	cell_type	0.65
TAU	phosphorylates	gene	0.65
ALZHEIMER'S DISEASE	inhibits	disease	0.65
APP	exacerbates	gene	0.65
AGING	activates	phenotype	0.65
STING	inhibits	gene	0.60
INTERNEURON	regulates	cell_type	0.60
NEURON	regulates	cell_type	0.60
HIPPOCAMPUS	expressed_in	brain_region	0.60
MTOR	associated_with	gene	0.50
PI3K	associated_with	gene	0.50
AKT	associated_with	gene	0.50
STEM CELLS	associated_with	cell_type	0.50
BDNF	associated_with	gene	0.50
FLUOXETINE	associated_with	drug	0.50
PSD95	associated_with	gene	0.50
ANGIOGENESIS	associated_with	phenotype	0.50
PHAGOCYTOSIS	associated_with	phenotype	0.45
MICROGLIA	associated_with	cell_type	0.45
NEUROGENESIS	associated_with	phenotype	0.45
APOPTOSIS	associated_with	phenotype	0.45
NEURONS	associated_with	cell_type	0.45
NEURON	associated_with	cell_type	0.45
AMYLOID-BETA	associated_with	protein	0.45
AMYLOID	associated_with	protein	0.45
TAU	associated_with	protein	0.45
APP	associated_with	gene	0.45
TH	associated_with	gene	0.45
EPO	associated_with	gene	0.45
NLRP3	associated_with	gene	0.45
GFAP	associated_with	gene	0.45
RIPK1	associated_with	gene	0.45
RIPK3	associated_with	gene	0.45
T CELLS	associated_with	cell_type	0.45
SENESCENCE	associated_with	phenotype	0.45
ASTROCYTE	associated_with	cell_type	0.45
BECN1	associated_with	gene	0.45
MELATONIN	associated_with	drug	0.45
ASTROGLIOSIS	associated_with	phenotype	0.45
SEMAGLUTIDE	associated_with	drug	0.45
ASTROCYTES	associated_with	cell_type	0.45
CX3CR1	associated_with	gene	0.45
AUTOPHAGY	associated_with	phenotype	0.45
CASP3	associated_with	gene	0.45
ACHE	associated_with	gene	0.45
MICROGLIA	co_discussed	cell_type	0.40
HIPPOCAMPUS	co_discussed	brain_region	0.40
FRONTAL	co_discussed	brain_region	0.40

Incoming (142)

Source	Relation	Type	Str
NEUROGENESIS	activates	phenotype	0.70
NEURONS	produces	cell_type	0.70
ALZHEIMER'S DISEASE	causes	disease	0.70
FLUOXETINE	treats	drug	0.70
CA1	regulates	brain_region	0.65
CA3	regulates	brain_region	0.65
CORTEX	regulates	brain_region	0.65
AMYLOID-BETA	phosphorylates	gene	0.65
HIPPOCAMPUS	inhibits	brain_region	0.65
T CELLS	activates	cell_type	0.65
MICROGLIA	regulates	cell_type	0.65
CORTEX	activates	brain_region	0.65
TAU	activates	protein	0.65
ANXIETY	causes	disease	0.60
ALZHEIMER	impairs	disease	0.60
ALZHEIMER'S	impairs	disease	0.60
ALZHEIMER'S DISEASE	impairs	disease	0.60
NEURONS	expressed_in	cell_type	0.55
MTOR SIGNALING	associated_with	pathway	0.50
PI3K/AKT/MTOR	associated_with	pathway	0.50
NEURAL STEM CELLS	associated_with	cell_type	0.50
SYNAPTIC PLASTICITY	associated_with	phenotype	0.50
PYRAMIDAL NEURONS	associated_with	cell_type	0.50
WNT SIGNALING	associated_with	pathway	0.50
GRANULE CELLS	associated_with	cell_type	0.50
LONG-TERM POTENTIATION	associated_with	phenotype	0.50
SYNAPTIC LOSS	associated_with	phenotype	0.45
ALPHA-SYNUCLEIN	associated_with	protein	0.45
ALZHEIMER'S DISEASE	associated_with	disease	0.45
OLIGODENDROCYTE	associated_with	cell_type	0.45
COMPLEMENT PATHWAY	associated_with	pathway	0.45
OXIDATIVE STRESS	associated_with	phenotype	0.45
MICROGLIAL ACTIVATION	associated_with	phenotype	0.45
OLIGODENDROCYTES	associated_with	cell_type	0.45
AMYGDALA	co_discussed	brain_region	0.40
CORTEX	co_discussed	brain_region	0.40
CA1	co_discussed	brain_region	0.40
CA3	co_discussed	brain_region	0.40
APP	co_discussed	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DENTATE GYRUS

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

NPM1 Gene

Neurons — Cell Type Hierarchy

GRIA3 Gene

NTF4 Protein

HNRNPA2B1 Protein

CNTN5 — Contactin 5

ncam2

ftd-tdp-pathology

CNTN6 — Contactin 6

Vitamin D Signaling Pathway in Neurodegeneration

CNTN4 — Contactin 4

Epigenetic Alterations in Alzheimer's Disease

CNTN3 — Contactin 3

ZDHHC13 — Zinc Finger DHHC-Type Containing 13

NPAS3 Gene

Braak Staging and Tau Propagation Pathway

Microglial Senescence Pathway in Neurodegeneration