gene

ABCA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ABCA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1167Connections

1Hypotheses

4Analyses

50Outgoing

50Incoming

1Experiments

4Debates

Summary

ABCA1 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, interacts with. Associated with AD, ALS, AMI. Connected to 280 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ABCA1
Full Name	ATP-Binding Cassette Transporter A1
Chromosome	9q31.1
Protein Type	Transporter
Target Class	Transporter
Function	is a full-size ABC transporter with a classic architecture
Mechanism of Action	Small molecule modulators to enhance cholesterol efflux and HDL formation
Primary Expression	Brain (astrocytes, microglia, neurons), liver, macrophages, intestine
Druggability	Medium (0.47)
Clinical Stage	Approved
Molecular Weight	~270 kDa
Amino Acids	2,461 amino acids
Exons	50
Pathways	Cholesterol, Epigenetic, Lipid Metabolism, Microrna, Mitochondrial Function
UniProt ID	O95477
NCBI Gene ID	19
Ensembl ID	ENSG00000165029
GeneCards	ABCA1
Human Protein Atlas	ABCA1
Associated Diseases	AD, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	25-Hydroxycholesterol, dexamethasone, quercetin, statins
Interactions	4E-BP1, abca2, ABCA2, ABCA4, ABCA7, ABCG1
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	HDL/apoE Particle Remodeling as a Therapeutic Swit
KG Connections	1164 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure Comparison — ABCA1 Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

7TBJ — X-ray / Cryo-EM

🔮 AI Predicted Structure

O95477 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ABCA1["ABCA1"] -->|"associated"| neurodegeneration["neurodegeneration"]
    ABCA1["ABCA1"] -->|"interacts"| LDLR["LDLR"]
    ABCA1["ABCA1"] -->|"interacts"| SREBF2["SREBF2"]
    ABCA1["ABCA1"] -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    ABCA1["ABCA1"] -->|"interacts"| Als["Als"]
    ABCA1["ABCA1"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
    h_9d29bfe5["h-9d29bfe5"] -->|"targets"| ABCA1["ABCA1"]
    LDLR_1["LDLR"] -->|"interacts"| ABCA1["ABCA1"]
    SREBF2_2["SREBF2"] -->|"interacts"| ABCA1["ABCA1"]
    ACTB["ACTB"] -->|"interacts"| ABCA1["ABCA1"]
    style ABCA1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (846)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ABCA1	data_in	dataset_row	0.00
benchmark_ot_ad_answer_key:ABCA1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
APOE	co_mentioned_with	gene	0.90
Lipid Efflux	promotes	process	0.90
Tau Pathology	suppresses	phenotype	0.90
Glial Lipid Accumulation	suppresses	phenotype	0.90
cholesterol homeostasis	participates_in	pathway	0.85
lipid efflux	regulates	process	0.85
Cholesterol Efflux	mediates	process	0.85
senescence	participates_in	pathway	0.80
Reverse Cholesterol Transport	participates_in	pathway	0.80
APOE	activates	gene	0.80
ALZHEIMER'S DISEASE	associated_with	disease	0.75
Tumor	activates	disease	0.75
Als	activates	disease	0.75
Atherosclerosis	activates	disease	0.75
Cancer	associated_with	disease	0.75
Atherosclerosis	inhibits	disease	0.75
ATP	activates	gene	0.70
Alzheimer's Disease	biomarker_for	disease	0.70
lipid metabolism	participates_in	pathway	0.70
Cholesterol	therapeutic_target	pathway	0.70
neural stem cells	regulates	cell_type	0.70
MTOR	inhibits	gene	0.70
ROS	treats	phenotype	0.70
CANCER	associated_with	gene	0.70
oxidative stress response	participates_in	pathway	0.70
CYP46A1	co_mentioned_with	gene	0.70
LDL	activates	gene	0.70
Mtor	inhibits	pathway	0.70
LDLR	interacts_with	gene	0.68
SREBF2	interacts_with	gene	0.68
neurodegeneration	associated_with	disease	0.68
Als	regulates	disease	0.65
Ms	causes	disease	0.65
Depression	associated_with	disease	0.65
Glioblastoma	regulates	disease	0.65
Cancer	regulates	disease	0.65
Neuroinflammation	causes	disease	0.65
Macular Degeneration	associated_with	disease	0.65
Tumor	interacts_with	disease	0.65
Glioma	therapeutic_target	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Alzheimer	causes	disease	0.65
Inflammation	causes	disease	0.65
Als	causes	disease	0.65
Alzheimer	regulates	disease	0.65
Ms	activates	disease	0.65

Incoming (321)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ABCA1	data_in	dataset_row	0.00
benchmark_ot_ad_answer_key:ABCA1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
h-64d92165	targets_gene	hypothesis	0.90
TNF	downregulates	protein	0.90
h-9d29bfe5	targets_gene	hypothesis	0.90
25-Hydroxycholesterol	modulates	compound	0.85
h-9d29bfe5	targets	hypothesis	0.80
ALZHEIMER DISEASE	associated_with	gene	0.80
SPP1	suppresses	gene	0.75
LXRα	upregulates	transcription_factor	0.70
ROS	activates	phenotype	0.70
APOE4	inhibits	gene	0.70
NEURONS	regulates	cell_type	0.70
ABCA7	interacts_with	protein	0.70
HDAC3	treats	gene	0.70
HDAC3	regulates	gene	0.70
HDAC3	inhibits	gene	0.70
AKT	inhibits	gene	0.70
PI3K	inhibits	gene	0.70
EGFR	inhibits	gene	0.70
SREBF2	interacts_with	gene	0.68
LDLR	interacts_with	gene	0.68
ISCHEMIA	activates	disease	0.65
SENESCENCE	regulates	phenotype	0.65
NLRP3 INFLAMMASOME	treats	pathway	0.65
MACROPHAGES	activates	cell_type	0.65
MACROPHAGES	inhibits	cell_type	0.65
P2RY12	treats	gene	0.65
OSTEOBLASTS	regulates	cell_type	0.65
APP	activates	gene	0.60
BACE1	activates	gene	0.60
HMGCR	expressed_in	gene	0.60
TNF	activates	gene	0.60
LDLR	expressed_in	gene	0.60
ABCG1	regulates	gene	0.60
APOE	regulates	gene	0.60
ABCG4	regulates	gene	0.60
SPTLC2	regulates	gene	0.60
SPTLC1	inhibits	gene	0.60
PSEN1	associated_with	gene	0.60
PLIN2	activates	gene	0.60
SOAT1	activates	gene	0.60
LYSOSOME	inhibits	gene	0.60
JUN	activates	gene	0.60
TAU	activates	gene	0.60
LDLR	regulates	gene	0.60
APOE	interacts_with	gene	0.60
APOE4	interacts_with	gene	0.60
CTSB	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
HDL/apoE Particle Remodeling as a Therapeutic Switch for CAA	0.766	neurodegeneration	What molecular mechanisms explain how ap

Mentioning Analyses (4)

Scientific analyses that reference this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
ABCA1 rs2230806 polymorphism association with dementia risk in hyperli	exploratory	dementia, Alzheimer's disease	0.900	0.00	human patients	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (4)

Multi-agent debates referencing this entity

ABCA1

Understanding Entity Pages

Summary

Wiki Pages (4)

ABCA1 - ATP-Binding Cassette Transporter A1

ABCA1 Gene

ABCA1→Cholesterol Efflux→APOE Lipidation→Alzheimer's Disease Causal Chain

ABCA1 Protein

Pathway Diagram

Outgoing (846)

Incoming (321)

Targeting Hypotheses (1)

Mentioning Analyses (4)

What molecular mechanisms explain how apoE promotes cerebral amyloid angiopathy

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Mechanistic role of APOE in neurodegeneration

Lipid raft composition changes in synaptic neurodegeneration

Experiments (1)

Related Papers (0)

Debates (4)

The study demonstrates that apoE is absolutely required for CAA development, as

Investigate how lipid raft composition (cholesterol metabolism, sphingolipids) c

Analysis question not specified

What gene expression changes in the aging mouse brain predict neurodegenerative