concept

ENDOTHELIAL CELLS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ENDOTHELIAL CELLS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1249Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

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💡 Concept Info

Name	ENDOTHELIAL CELLS
Key Genes/Proteins	AKT, ALZHEIMER, AMPK, AMYLOID, APP
Related Diseases	aging, ALS, Alzheimer'S Disease, ALZHEIMER'S DISEASE

Pathway Diagram

graph TD
    ENDOTHELIAL_CELLS["ENDOTHELIAL CELLS"]
    ENDOTHELIAL_CELLS -->|"involved_in"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    ENDOTHELIAL_CELLS -->|"product_of"| Exosomes["Exosomes"]
    ENDOTHELIAL_CELLS -->|"component_of"| Neurovascular_Unit["Neurovascular Unit"]
    ENDOTHELIAL_CELLS -->|"activates"| ROS["ROS"]
    ENDOTHELIAL_CELLS -->|"activates"| TNF["TNF"]
    ENDOTHELIAL_CELLS -->|"activates"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    ENDOTHELIAL_CELLS -->|"interacts"| NEURON["NEURON"]
    ENDOTHELIAL_CELLS -->|"interacts"| PERICYTES["PERICYTES"]
    NETs["NETs"] -->|"causes"| ENDOTHELIAL_CELLS
    BMAL1["BMAL1"] -->|"expressed in"| ENDOTHELIAL_CELLS
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| ENDOTHELIAL_CELLS
    APOPTOSIS["APOPTOSIS"] -->|"activates"| ENDOTHELIAL_CELLS
    BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"] -->|"interacts"| ENDOTHELIAL_CELLS
    CD2AP["CD2AP"] -->|"expressed in"| ENDOTHELIAL_CELLS
    TDP43["TDP43"] -->|"expressed in"| ENDOTHELIAL_CELLS

Outgoing (272)

Target	Relation	Type	Str
Exosomes	product_of	organelle	0.95
PERICYTES	interacts_with	cell_type	0.95
Neurovascular Unit	component_of	process	0.95
ROS	activates	protein	0.95
Blood-Brain Barrier	involved_in	process	0.95
blood-brain barrier	involved_in	process	0.95
NEURON	interacts_with	cell_type	0.95
OXIDATIVE STRESS	activates	process	0.95
TNF	activates	gene	0.95
Wound Healing	contributes_to	process	0.90
LRP1	expressed_in	gene	0.90
Wound Healing	involved_in	process	0.90
NTN1	expressed_in	protein	0.85
Hepatic Ischemia-Reperfusion Injury	involved_in	disease	0.85
Aging	associated_with	process	0.85
Alzheimer'S Disease	associated_with	disease	0.85
ALS	associated_with	disease	0.85
Metabolic Ad Subtype	associated_with	phenotype	0.85
Angiogenesis	involved_in	process	0.85
Alzheimer's disease	activates	disease	0.80
INFLAMMATION	activates	process	0.80
MICROGLIA	activates	cell_type	0.80
VEGF	regulates	gene	0.80
blood-brain barrier	active_in	pathway	0.75
TJP1	regulates	gene	0.70
FERROPTOSIS	inhibits	phenotype	0.70
NEUROINFLAMMATION	inhibits	phenotype	0.70
MONOCYTES	interacts_with	cell_type	0.70
CXCL10	inhibits	gene	0.70
NEUROINFLAMMATION	regulates	phenotype	0.70
NEUROINFLAMMATION	activates	phenotype	0.70
BBB integrity	modulates	phenotype	0.70
NEURODEGENERATION	causes	phenotype	0.70
NEURODEGENERATION	destabilizes	phenotype	0.70
LRP1	regulates	gene	0.70
NEUROINFLAMMATION	treats	phenotype	0.70
TNF	protects_against	gene	0.65
UBIQUITIN	inhibits	protein	0.65
UBIQUITIN	regulates	protein	0.65
MACROPHAGES	protects_against	cell_type	0.65
ASTROCYTE	treats	cell_type	0.65
INFLAMMATION	associated_with	process	0.65
FERROPTOSIS	regulates	process	0.65
MICROGLIA	regulates	cell_type	0.65
PI3K	activates	gene	0.65
NEURON	causes	cell_type	0.65
FERROPTOSIS	activates	process	0.65
MACROPHAGES	regulates	cell_type	0.65
SENESCENCE	regulates	process	0.65
NF-KB	activates	gene	0.65

Incoming (977)

Source	Relation	Type	Str
NETs	causes	process	0.95
AUTOPHAGY	activates	process	0.95
APOPTOSIS	activates	process	0.95
BMAL1	expressed_in	protein	0.95
Nets	causes	process	0.92
VEGF	expressed_in	gene	0.90
AQP1	expressed_in	protein	0.90
TNF	expressed_in	gene	0.90
aging	affects	disease	0.90
Netrin-1	activates	gene	0.90
NF-kB signaling	active_in	pathway	0.90
NTN1	expressed_in	protein	0.90
Alzheimer's disease	affects	disease	0.90
CD2AP	expressed_in	protein	0.90
stroke	affects	disease	0.90
diabetes	affects	disease	0.90
THBS1	targets	protein	0.90
unfolded protein response	active_in	pathway	0.90
38941455	transfer mitochondria to	paper	0.90
LRP1	expressed_in	gene	0.90
nitric oxide	released_by	neurotransmitter	0.90
TDP43	expressed_in	protein	0.90
Oligonucleotide Transport Vehicle	expressed_in	drug	0.85
FGF2	expressed_in	protein	0.85
PIEZO1	expressed_in	gene	0.85
PI3K	activates	gene	0.80
DNA	expressed_in	gene	0.80
ferroptosis	active_in	pathway	0.80
BECN1	expressed_in	gene	0.80
neuroinflammation	affects	disease	0.80
WNT	expressed_in	gene	0.80
CD31	expressed_in	gene	0.80
pyroptosis	active_in	pathway	0.80
VEGF	regulates	gene	0.80
TGF	expressed_in	gene	0.80
ROS	activates	gene	0.80
BECN1	activates	gene	0.80
VEGFA	expressed_in	gene	0.80
APOE	expressed_in	gene	0.80
IFN	expressed_in	gene	0.80
RAGE	expressed_in	gene	0.80
NETS	induces	process	0.80
BECN1	regulates	gene	0.80
ANGIOGENESIS	regulates	process	0.80
ASTROCYTES	interacts_with	cell_type	0.80
PI3K	expressed_in	gene	0.80
complement cascade	active_in	pathway	0.80
neurodegeneration	affects	disease	0.80
VEGF	associated_with	gene	0.80
MALAT1	expressed_in	gene	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evalua

neurodegeneration | 2026-04-28 | 7 hypotheses Top: 0.662

Can ferroptosis inhibitors prevent BBB disruption and edema formation after card

neurodegeneration | 2026-04-25 | 7 hypotheses Top: 0.760

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evalua

active · Rounds: 4 · Score: 0.76 · 2026-04-28

Can ferroptosis inhibitors prevent BBB disruption and edema formation after card

closed · Rounds: 4 · Score: 0.73 · 2026-04-25

Related Research

Hypotheses and analyses mentioning ENDOTHELIAL CELLS in their description or question text

No additional research found