concept

INOS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INOS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

416Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	INOS
Key Genes/Proteins	ABCA7, Actin, AGING, AIF, AIF1, Akt
Related Diseases	Aging, Als, ALS, Alzheimer, ALZHEIMER'S DISEASE
Related Pathways	Alpha-Synuclein

Pathway Diagram

graph TD
    INOS["INOS"]
    style INOS fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    INOS -->|"activates"| Tumor["Tumor"]
    INOS -->|"activates"| Parkinson["Parkinson"]
    INOS -->|"activates"| Inflammation["Inflammation"]
    INOS -->|"expressed in"| ALS["ALS"]
    INOS -->|"activates"| Alzheimer["Alzheimer"]
    INOS -->|"activates"| Multiple_Sclerosis["Multiple Sclerosis"]
    INOS -->|"activates"| Huntington["Huntington"]
    INOS -->|"activates"| Neurodegeneration["Neurodegeneration"]
    INOS -->|"activates"| Ischemia["Ischemia"]
    TNF([TNF]) -.->|"inhibits"| INOS
    TGM2([TGM2]) -->|"co_expressed_with"| INOS
    IL_10([IL-10]) -->|"expressed in"| INOS
    CATALASE([CATALASE]) -->|"activates"| INOS
    OXIDATIVE_STRESS([OXIDATIVE STRESS]) -->|"activates"| INOS
    ROS([ROS]) -->|"activates"| INOS
    NRF1([NRF1]) -->|"activates"| INOS
    INFLAMMATION([INFLAMMATION]) -->|"activates"| INOS
    BDNF([BDNF]) -->|"expressed in"| INOS

Outgoing (244)

Target	Relation	Type	Str
Neurodegeneration	contributes_to	process	0.90
M1 pro-inflammatory phenotype	biomarker_for	cell_type	0.70
Als	associated_with	disease	0.65
Als	regulates	disease	0.65
Depression	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
ALS	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Autoimmune	activates	disease	0.65
Als	inhibits	disease	0.65
Inflammation	protects_against	disease	0.65
Aging	activates	disease	0.65
Alzheimer	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Huntington	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
Ischemia	activates	disease	0.65
ALS	activates	disease	0.65
Als	activates	disease	0.65
Tumor	activates	disease	0.65
Parkinson	activates	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Inflammation	activates	disease	0.65
Pyroptosis	therapeutic_target	disease	0.65
Inflammation	inhibits	disease	0.65
ALS	associated_with	disease	0.65
Stroke	activates	disease	0.65
Aging	associated_with	disease	0.65
Cancer	regulates	disease	0.65
Als	biomarker_for	disease	0.65
Ischemia	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
Alzheimer	expressed_in	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
P38	degrades	gene	0.60
ERK	degrades	gene	0.60
APOPTOSIS	inhibits	gene	0.60
BAX	degrades	gene	0.60
Apoptosis	inhibits	pathway	0.60
Mapk	inhibits	pathway	0.60
Nf-Κb	degrades	pathway	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
MICROGLIA	expressed_in	gene	0.60
Neuroinflammatory	expressed_in	pathway	0.60
Nf-Κb	inhibits	pathway	0.60
P38	inhibits	gene	0.60
PARKINSON'S DISEASE	inhibits	gene	0.60
TNF-Α	inhibits	gene	0.60

Incoming (172)

Source	Relation	Type	Str
NF-KB	associated_with	protein	0.96
Lipopolysaccharide	upregulates	compound	0.95
ASTROCYTES	expressed_in	cell_type	0.90
TG2	associated_with	gene	0.85
ROS	regulates	process	0.85
BIG1	upregulates	gene	0.85
CASTRATION	upregulates	process	0.80
DHT	inhibits	compound	0.80
ALZHEIMER'S DISEASE	associated_with	disease	0.80
TREM2	upregulates	gene	0.80
Microglia-like cells	downregulates	cell_type	0.80
TNF	associated_with	gene	0.72
CASP3	associated_with	gene	0.72
PARKINSON'S DISEASE	associated_with	disease	0.72
TNF	inhibits	gene	0.64
STAT3	expressed_in	gene	0.60
NEURODEGENERATION	activates	gene	0.60
PARKINSON	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
HUNTINGTON	activates	gene	0.60
C1QB	biomarker_for	gene	0.60
ITGAM	biomarker_for	gene	0.60
PHAGOCYTOSIS	associated_with	gene	0.60
IL-1	degrades	gene	0.60
BAX	degrades	gene	0.60
PER	activates	gene	0.60
GFAP	expressed_in	gene	0.60
TRAF6	expressed_in	gene	0.60
GASTRODIN	activates	gene	0.60
TGM2	co_expressed_with	protein	0.60
IFN	causes	gene	0.60
PPAR	inhibits	gene	0.60
MICROGLIA	expressed_in	gene	0.60
STROKE	activates	gene	0.60
CATALASE	expressed_in	gene	0.60
IL10	expressed_in	gene	0.60
CYTOKINES	expressed_in	gene	0.60
OXIDATIVE STRESS	expressed_in	gene	0.60
GPX4	expressed_in	gene	0.60
NRF2	activates	gene	0.60
CYTOKINES	causes	gene	0.60
NF-ΚB	activates	gene	0.60
Ramalin	suppresses	gene	0.60
IL-6	causes	gene	0.60
IFN-Γ	causes	gene	0.60
TNF	causes	gene	0.60
HO-1	activates	gene	0.60
FOS	activates	gene	0.60
C-FOS	activates	gene	0.60
JUN	activates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
APOE4-driven loss of neuronal PI(4,5)P2 bridges ganglioside-	0.380	alzheimer	Lipid metabolism dysregulation and membr
Phosphoinositide Signaling Restoration via PIP5K1C Activatio	0.000	-	Lipid metabolism dysregulation and membr

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning INOS in their description or question text

No additional research found