concept

INOS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INOS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

422Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	INOS
Key Genes/Proteins	NF-KB, TG2, TREM2, CASP3, TNF
Related Diseases	ALZHEIMER'S DISEASE, PARKINSON'S DISEASE, Tumor, Parkinson, Inflammation

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    INOS["INOS"]
    style INOS fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    INOS -->|"activates"| Tumor["Tumor"]
    INOS -->|"activates"| Parkinson["Parkinson"]
    INOS -->|"activates"| Inflammation["Inflammation"]
    INOS -->|"expressed in"| ALS["ALS"]
    INOS -->|"activates"| Alzheimer["Alzheimer"]
    INOS -->|"activates"| Multiple_Sclerosis["Multiple Sclerosis"]
    INOS -->|"activates"| Huntington["Huntington"]
    INOS -->|"activates"| Neurodegeneration["Neurodegeneration"]
    INOS -->|"activates"| Ischemia["Ischemia"]
    TNF([TNF]) -.->|"inhibits"| INOS
    TGM2([TGM2]) -->|"co_expressed_with"| INOS
    IL_10([IL-10]) -->|"expressed in"| INOS
    CATALASE([CATALASE]) -->|"activates"| INOS
    OXIDATIVE_STRESS([OXIDATIVE STRESS]) -->|"activates"| INOS
    ROS([ROS]) -->|"activates"| INOS
    NRF1([NRF1]) -->|"activates"| INOS
    INFLAMMATION([INFLAMMATION]) -->|"activates"| INOS
    BDNF([BDNF]) -->|"expressed in"| INOS

Outgoing (251)

Target	Relation	Type	Str
Neurodegeneration	contributes_to	process	0.90
Tumor	activates	disease	0.65
Parkinson	activates	disease	0.65
Inflammation	activates	disease	0.65
ALS	expressed_in	disease	0.65
Alzheimer	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Huntington	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Ischemia	activates	disease	0.65
ALS	activates	disease	0.65
Inflammation	protects_against	disease	0.65
Neuroinflammation	activates	disease	0.65
Aging	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Ischemia	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Alzheimer	regulates	disease	0.65
Alzheimer	expressed_in	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Parkinson	inhibits	disease	0.65
Stroke	activates	disease	0.65
Autoimmune	activates	disease	0.65
Als	expressed_in	disease	0.65
Als	activates	disease	0.65
Als	associated_with	disease	0.65
Aging	activates	disease	0.65
Pyroptosis	therapeutic_target	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Als	regulates	disease	0.65
Depression	activates	disease	0.65
Als	inhibits	disease	0.65
Als	biomarker_for	disease	0.65
Cancer	regulates	disease	0.65
AND	activates	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
TNF-Α	expressed_in	gene	0.60
HSF1	activates	gene	0.60
PARKINSON	activates	gene	0.60
GAIN	activates	gene	0.60
GSH	expressed_in	gene	0.60
CAT	expressed_in	gene	0.60
Oxidative Stress	activates	pathway	0.60
Apoptosis	expressed_in	pathway	0.60
AND	expressed_in	gene	0.60
RANK	expressed_in	gene	0.60
Oxidative Stress	expressed_in	pathway	0.60
AND	causes	gene	0.60

Incoming (171)

Source	Relation	Type	Str
NF-KB	associated_with	protein	0.96
Lipopolysaccharide	upregulates	compound	0.95
ASTROCYTES	expressed_in	cell_type	0.90
TG2	associated_with	gene	0.85
ROS	regulates	process	0.85
ALZHEIMER'S DISEASE	associated_with	disease	0.80
TREM2	upregulates	gene	0.80
Microglia-like cells	downregulates	cell_type	0.80
CASP3	associated_with	gene	0.72
PARKINSON'S DISEASE	associated_with	disease	0.72
TNF	associated_with	gene	0.72
TNF	inhibits	gene	0.64
IL-10	expressed_in	gene	0.60
CATALASE	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
ROS	activates	gene	0.60
NRF1	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
BDNF	expressed_in	gene	0.60
CATALASE	expressed_in	gene	0.60
IL10	expressed_in	gene	0.60
CYTOKINES	expressed_in	gene	0.60
OXIDATIVE STRESS	expressed_in	gene	0.60
GPX4	expressed_in	gene	0.60
NRF2	activates	gene	0.60
CYTOKINES	causes	gene	0.60
NF-ΚB	activates	gene	0.60
IFN	causes	gene	0.60
IL-6	causes	gene	0.60
IFN-Γ	causes	gene	0.60
TNF	causes	gene	0.60
HO-1	activates	gene	0.60
FOS	activates	gene	0.60
C-FOS	activates	gene	0.60
JUN	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
PARKINSON	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
HUNTINGTON	activates	gene	0.60
INFLAMMATION	protects_against	gene	0.60
BRAIN INJURY	protects_against	gene	0.60
OXIDATIVE STRESS	protects_against	gene	0.60
ROS	protects_against	gene	0.60
IL-10	activates	gene	0.60
CYTOKINES	activates	gene	0.60
IL-13	activates	gene	0.60
MAPK	activates	gene	0.60
P38	activates	gene	0.60
BCL-2	activates	gene	0.60
BAX	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Lipid metabolism dysregulation and membrane integrity in Alzheimer disease

neurodegeneration | 2026-04-04 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

INOS

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Corticobasal Syndrome (CBS)

Parthanatos in Neurodegeneration

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

neuroinflammation

Astrocyte Reactivity Mechanism

TREM2 Microglial Signaling Pathway in Neurodegeneration

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

vitamin-d-therapy-neurodegeneration

Curcumin for Neurodegeneration

DNA Damage Response Impairment Pathway

Genistein for Mild Cognitive Impairment (NCT07385937)

NF-kB Signaling Pathway in Neurodegeneration

Neuroinflammation Across AD, PD, ALS, FTD, and HD

Gut-Microbiome-Neurodegeneration Axis

cGMP Signaling Pathway in Neurodegeneration

TGF-β Signaling in Parkinson's Disease

vegfr-signaling-neurodegeneration

Neuroinflammation in Parkinson's Disease